Single-molecule analysis of ligand efficacy in β2AR–G-protein activation

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis

(2015) Angelica Ferguson et al.   MOLECULAR CELL

Conformational dynamics of a class C G-protein-coupled receptor

(2015) Reza Vafabakhsh et al.   NATURE

Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

(2015) Marjorie Damian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR

(2015) Rajan Lamichhane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for nucleotide exchange in heterotrimeric G proteins

(2015) R. O. Dror et al.   SCIENCE

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

(2014) Aashish Manglik et al.   CURRENT OPINION IN CELL BIOLOGY

A Conserved Phenylalanine as a Relay between the α5 Helix and the GDP Binding Region of Heterotrimeric GiProtein α Subunit

(2014) Ali I. Kaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

New concepts in pharmacological efficacy at 7TM receptors: IUPHAR Review 2

(2012) Terry Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Inactive-state preassembly of Gq-coupled receptors and Gq heterotrimers

(2011) Kou Qin et al.   Nature Chemical Biology

Structural flexibility of the G s  -helical domain in the  2-adrenoceptor Gs complex

(2011) G. H. Westfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptors

(2010) Jillian G Baker   BRITISH JOURNAL OF PHARMACOLOGY

Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins

(2009) Neeraj Kapoor et al.   JOURNAL OF MOLECULAR BIOLOGY

Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells

(2009) Jean-Pierre Vilardaga et al.   MOLECULAR ENDOCRINOLOGY

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

(2009) X. J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA