The role of lysosome in cell death regulation

The anti-malarial chloroquine suppresses proliferation and overcomes cisplatin resistance of endometrial cancer cells via autophagy inhibition

(2015) Tomohiko Fukuda et al.   GYNECOLOGIC ONCOLOGY

Selective autophagy: Lysophagy

(2015) Junya Hasegawa et al.   METHODS

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

(2015) Gregory Hook et al.   Frontiers in Neurology

Cathepsin Inhibition-Induced Lysosomal Dysfunction Enhances Pancreatic Beta-Cell Apoptosis in High Glucose

(2015) Minjeong Jung et al.   PLoS One

Deficiency for the Cysteine Protease Cathepsin L Impairs Myc-Induced Tumorigenesis in a Mouse Model of Pancreatic Neuroendocrine Cancer

(2015) Nicola R. Brindle et al.   PLoS One

Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway

(2014) Min Xu et al.   GLIA

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

(2014) Raquel Fucho et al.   JOURNAL OF HEPATOLOGY

Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD

(2014) Manuela Salerno et al.   PLoS One

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

TNF -induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation

(2013) J. Huai et al.   JOURNAL OF CELL SCIENCE

GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L-Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells

(2013) J. L. Schwartz-Roberts et al.   MOLECULAR CANCER THERAPEUTICS

Induction of reactive oxygen species generation inhibits epithelial-mesenchymal transition and promotes growth arrest in prostate cancer cells

(2013) Trinath P. Das et al.   MOLECULAR CARCINOGENESIS

Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling

(2013) Francis Kobia et al.   Molecular Oncology

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

(2013) Han-Ming Shen et al.   TRENDS IN BIOCHEMICAL SCIENCES

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment

(2012) Valérie Laurent-Matha et al.   FASEB JOURNAL

Cancer-associated lysosomal changes: friends or foes?

(2012) T Kallunki et al.   ONCOGENE

Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content

(2012) Hanna Appelqvist et al.   PLoS One

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic

(2011) Sophie Denamur et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

Stat3 controls lysosomal-mediated cell death in vivo

(2011) Peter A. Kreuzaler et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Chelation of lysosomal iron protects against ionizing radiation

(2010) Carsten Berndt et al.   BIOCHEMICAL JOURNAL

Combating apoptosis and multidrug resistant cancers by targeting lysosomes

(2010) Line Groth-Pedersen et al.   CANCER LETTERS

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

(2010) C Oberle et al.   CELL DEATH AND DIFFERENTIATION

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

p53 and ARF: unexpected players in autophagy

(2010) Gregor M. Balaburski et al.   TRENDS IN CELL BIOLOGY

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Delivery of endocytosed membrane proteins to the lysosome

(2009) Paul R. Pryor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cysteine cathepsins are not critical for TNF-α-induced cell death in T98G and U937 cells

(2009) Martina Klarić et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Heat Shock Protein 70 Inhibits Apoptosis in Cancer Cells Through Simultaneous and Independent Mechanisms

(2009) Vikas Dudeja et al.   GASTROENTEROLOGY

Granulysin Induces Cathepsin B Release from Lysosomes of Target Tumor Cells to Attack Mitochondria through Processing of Bid Leading to Necroptosis

(2009) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

Redox-Dependent Translocation of p53 to Mitochondria or Nucleus in Human Melanocytes after UVA- and UVB-Induced Apoptosis

(2009) Petra K. Wäster et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy

(2008) Alison R. Hayman   AUTOIMMUNITY

Loss of membrane cholesterol influences lysosomal permeability to potassium ions and protons

(2008) Dong Deng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

(2008) N. Fehrenbacher et al.   CANCER RESEARCH

Targeting the extrinsic apoptosis pathway in cancer

(2008) Avi Ashkenazi   CYTOKINE & GROWTH FACTOR REVIEWS

Oxidative stress induces macroautophagy of amyloid β-protein and ensuing apoptosis

(2008) Lin Zheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

(2008) Gabriela Droga-Mazovec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

(2008) Sébastien Conus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE

Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins

(2008) P. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cysteine cathepsin proteases as pharmacological targets in cancer

(2007) Carmela Palermo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES