Targeting the lysosome in cancer

Synthesis and Evaluation of Cleistanthin A Derivatives as Potent Vacuolar H+-ATPase Inhibitors

(2015) Yu Zhao et al.   Chemical Biology & Drug Design

Heme oxygenase-1 enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis

(2015) Chenglong Dong et al.   EXPERIMENTAL CELL RESEARCH

Synthesis of Improved Lysomotropic Autophagy Inhibitors

(2015) Tong Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective autophagy: Lysophagy

(2015) Junya Hasegawa et al.   METHODS

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Emerging strategies to effectively target autophagy in cancer

(2015) V W Rebecca et al.   ONCOGENE

Discovery of Autophagy Inhibitors with Antiproliferative Activity in Lung and Pancreatic Cancer Cells

(2015) Lars Ulrik Nordstrøm et al.   ACS Medicinal Chemistry Letters

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

(2015) Nathalie Meo-Evoli et al.   Oncotarget

Abstract 4545: Anticancer effects and mechanism of VR23, a novel chloroquine derivative

(2015) Hai-Yen Thi Vu et al.   CANCER RESEARCH

Targeting Cathepsin E in Pancreatic Cancer by a Small Molecule Allows In Vivo Detection

(2015) Edmund J. Keliher et al.   NEOPLASIA

LC3-associated phagocytosis

(2014) Susana Romao et al.   Autophagy

The current stage of cathepsin B inhibitors as potential anticancer agents

(2014) Janko Kos et al.   Future Medicinal Chemistry

Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia

(2014) N. Yuan et al.   HAEMATOLOGICA

Lysosomal membrane permeabilization in cell death: Concepts and challenges

(2014) Urška Repnik et al.   MITOCHONDRION

Efficacy of a Cathepsin K Inhibitor in a Preclinical Model for Prevention and Treatment of Breast Cancer Bone Metastasis

(2014) L. T. Duong et al.   MOLECULAR CANCER THERAPEUTICS

Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering

(2014) Dan Fu et al.   Nature Chemistry

The Complex Ultrastructure of the Endolysosomal System

(2014) J. Klumperman et al.   Cold Spring Harbor Perspectives in Biology

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

The role of necroptosis, an alternative form of cell death, in cancer therapy

(2013) Xinfang Yu et al.   Expert Review of Anticancer Therapy

Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization

(2013) Donna M. Small et al.   INTERNATIONAL JOURNAL OF CANCER

V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activationin vivo

(2013) Rebekka Kubisch et al.   INTERNATIONAL JOURNAL OF CANCER

Dipeptide mimic oligomer transporter mediates intracellular delivery of Cathepsin D inhibitors: A potential target for cancer therapy

(2013) Marie Maynadier et al.   JOURNAL OF CONTROLLED RELEASE

Effects of novel human cathepsin S inhibitors on cell migration in human cancer cells

(2013) Ju-Ying Tsai et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells

(2013) Georgios Kallifatidis et al.   Marine Drugs

Killing from the inside

(2013) Paul Saftig et al.   NATURE

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

The Endolysosomal System in Cell Death and Survival

(2013) U. Repnik et al.   Cold Spring Harbor Perspectives in Biology

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma

(2013) M Granato et al.   Cell Death & Disease

Lys05

(2012) Ravi K. Amaravadi et al.   Autophagy

Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer

(2012) N. P. Withana et al.   CANCER RESEARCH

Lysosomal pathways to cell death and their therapeutic applications

(2012) Maruša Hafner Česen et al.   EXPERIMENTAL CELL RESEARCH

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

(2012) Kevin Bray et al.   PLoS One

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomes and lysosomal cathepsins in cell death

(2011) Urška Repnik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance

(2011) K. J. Gotink et al.   CLINICAL CANCER RESEARCH

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

(2011) J. I.-J. Leu et al.   MOLECULAR CANCER RESEARCH

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Lysosomal membrane proteins: life between acid and neutral conditions: Figure 1

(2010) Paul Saftig et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation

(2010) Y.H. Zeidan et al.   CURRENT MOLECULAR MEDICINE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The proteome of lysosomes

(2010) Bernd A. Schröder et al.   PROTEOMICS

Cathepsin K inhibitors for osteoporosis and potential off-target effects

(2009) Dieter Brömme et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cathepsin L, target in cancer treatment?

(2009) Jacqueline M. Lankelma et al.   LIFE SCIENCES

Major cell death pathways at a glance

(2009) Linde Duprez et al.   MICROBES AND INFECTION

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomal involvement in cell death and cancer

(2008) Thomas Kirkegaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysosomes in iron metabolism, ageing and apoptosis

(2008) Tino Kurz et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Acid Sphingomyelinase Overexpression Enhances the Antineoplastic Effects of Irradiation In Vitro and In Vivo

(2008) Eric L Smith et al.   MOLECULAR THERAPY

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE