Review
Spectroscopy
Fangbo Xia, Jian-Bo Wan
Summary: Lipids play essential roles in biological functions and mass spectrometry is the preferred method for lipid analysis. However, untargeted qualitative profiling and absolute quantitation of lipids are still challenging due to their structural diversity and similarity. Chemical derivatization techniques have been developed to improve lipidomic analysis, providing more structural information and better analytical performance.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Chemistry, Medicinal
Jiang-Kun Dai, Wen-Jia Dan, Jian-Bo Wan
Summary: This review summarizes the research progress on the antifungal activity of beta-carbolines and discusses their mechanisms and structure-activity relationships. Beta-carbolines are considered as promising candidates for the development of new and efficient antifungal drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Li-Juan Ma, Ni Ma, Ji-Liang Cao, Jian-Bo Wan
Summary: The study found that different drying methods significantly influence the chemical components in Panax notoginseng leaves (PNL), with sun-air drying and hot-air drying leading to vigorous ginsenoside transformation. Specifically, the main components of PNL can be transformed into different compounds by selective cleavage of beta-1,2-glucosidic linkage, with only steaming prior to drying able to inhibit this transformation. These findings provide a scientific basis for designing industrial drying methods to ensure PNL quality.
Article
Integrative & Complementary Medicine
Jian Zou, Chunyan Yan, Jian-Bo Wan
Summary: Red yeast rice (RYR) has been found to improve non-alcoholic fatty liver disease (NAFLD) by modulating the NF-kappa B/NLRP3 inflammasome and lipid synthesis pathways. RYR reduces lipid accumulation and hepatic inflammation, regulates lipid metabolism, and inhibits the inflammatory response in mice and cell models.
Article
Biochemistry & Molecular Biology
Tianzhen He, Kai Wang, Peng Zhao, Guanqun Zhu, Xinbao Yin, Yulian Zhang, Zongliang Zhang, Kai Zhao, Zhenlin Wang, Ke Wang
Summary: Ulcerative colitis is a complex inflammatory bowel disease with a genetic and immune etiology. This study identified potential biomarkers for ulcerative colitis and analyzed immune cell infiltration characteristics using bioinformatic analyses. The differentially expressed mRNAs (DEMs) were mainly enriched in infiltrating neutrophils and regulation of leukocyte migration. Specifically, three candidate biomarkers were strongly correlated with infiltrating immune cells of ulcerative colitis. These findings suggest the importance of these genes as diagnostic biomarkers and the involvement of immune infiltration cells in the progression of ulcerative colitis.
Review
Food Science & Technology
Bingren Tian, Jiayue Liu, Yumei Liu, Jian-Bo Wan
Summary: The popularity of plant bioactive ingredients in the food industry is increasing. However, these ingredients have some deficiencies. Cyclodextrins (CDs) have been extensively studied as excellent carriers for plant bioactive ingredients and can be added to film materials to create bioactive food packaging. This review summarizes the extraction methods of plant bioactive ingredients, the addition of CD inclusion compounds to thin-film materials, and their applications in food packaging. The release model and mechanism of active film materials based on various plant bioactive ingredients with CDs are also highlighted.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Yan Hu, Zhe Wang, Jiayue Liu, Wen Yang, Qiang Yang, Yuan-Cai Liu, Qiu-Yun You, Xiao-Jia Chen, Jian-Bo Wan
Summary: In this study, the chemical stability of a Chinese herbal spirit, CHS-J, during the storage period was characterized using a metabolomics approach. Several components were found to significantly change, especially under high temperature and light exposure. These chemical changes had little influence on the anti-fatigue effect of the spirit.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Kai Wang, Chao Yang, Haibin Li, Xiaoyan Liu, Meiling Zheng, Zixue Xuan, Zhiqiang Mei, Haiyong Wang
Summary: JMJD6 is a histone demethylase belonging to the Jumonji domain family, involved in the regulation of transcription, chromatin structure, epigenetics, and genome integrity. Abnormal expression of JMJD6 is associated with various tumors and it also regulates the immune response. Targeting the JMJD6 gene may be a promising strategy for cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Chenyue Zhang, Kai Wang, Jiamao Lin, Haiyong Wang
Summary: This study explored the association between TP53 mutation and atezolizumab in non-small-cell lung cancer (NSCLC) patients. It was found that NSCLC patients with TP53/KRAS co-mutation had longer overall survival (OS) with atezolizumab compared to docetaxel. However, there was no significant difference in OS between atezolizumab and docetaxel for NSCLC patients with only TP53 mutation or KRAS mutation.
Review
Agriculture, Multidisciplinary
Bingren Tian, Jiayue Liu, Wanzhexi Yang, Jian-Bo Wan
Summary: Petroleum-based packaging materials are harmful to the environment and human health due to their nonbiodegradable nature. Researchers are now focusing on developing efficient, biodegradable, and nontoxic food packaging films. Essential oils (EOs) are being used as a natural alternative to synthetic additives due to their favorable antioxidant and antibacterial properties. This review summarizes the mechanisms of EOs and analyzes the properties and performance of food packaging films incorporating EOs. The future prospects and challenges of using EOs-containing biopolymer films in food packaging are also discussed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jiayue He, Shuguang Liu, Qi Tan, Zhiying Liu, Jiewen Fu, Ting Li, Chunli Wei, Xiaoyan Liu, Zhiqiang Mei, Jingliang Cheng, Kai Wang, Junjiang Fu
Summary: This study evaluated the inhibitory effects of cordycepin, thymoquinone, and N6, N6-dimethyladenosine on ADAM17 in cancer cells and predicted their potential in anti-COVID-19 therapy. The results showed that these compounds suppressed the expression of ADAM17 and had potential against SARS-CoV-2. Pharmacological analysis indicated that ADAM17 might be a target for anti-COVID-19 therapy with these compounds.
Review
Immunology
Qi Wang, Kai Wang, Xiaojing Tan, Zhenxiang Li, Haiyong Wang
Summary: Metalloproteinases (MPs) are a family of proteinases that contain metal ions in their active centers. They play various roles in cancer, including protein hydrolysis, cell adhesion, and remodeling of the extracellular matrix. MPs are expressed in multiple types of cancers and participate in pathological processes involving tumor development, invasion, and metastasis by regulating signal transduction and the tumor microenvironment. In this review, we summarize the structure of MPs, their expression, and especially their immunomodulatory role and mechanisms in cancers. We also provide an update on recent advances and future directions in the diagnosis and immunotherapy targeting MPs in cancers.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Kai Wang, Zixue Xuan, Xiaoyan Liu, Meiling Zheng, Chao Yang, Haiyong Wang
Summary: ADAM17 is a transmembrane protease involved in cell membrane protein shedding and signal pathway regulation. It has been shown to regulate over 90 substrates, some of which play important roles in tumor formation and development. ADAM17 also has immunomodulatory roles, although the mechanisms are still not well understood. This paper provides a summary of the structure, regulatory roles, and immunomodulatory functions of ADAM17, as well as the potential use of small molecule inhibitors and monoclonal antibodies for targeting ADAM17.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Chenyue Zhang, Kai Wang, Wenjie Liu, Jiamao Lin, Zhenxiang Li, Hui Wang, Chenglong Zhao, Yanhua Chen, Shuangxiu Wu, Airong Yang, Jiayan Wu, Haiyong Wang
Summary: This study describes the genomic and immunological landscape of Chinese mucinous pulmonary adenocarcinoma (MPA) and compares it with classical lung adenocarcinoma (LUAD). It is found that MPA has distinct genomic alterations and a more complex genomic profile compared to LUAD. Mutations in specific pathways are associated with survival outcomes, and mutations in immune-related genes also affect prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jian Zou, Rujie Yang, Ruibing Feng, Jiayue Liu, Jian-Bo Wan
Summary: The potential beneficial effects of ginsenoside Rk2 in mitigating alcoholic liver injury in mice are reported. Rk2 acts as an inhibitor of the NLRP3 inflammasome signaling in the liver, reducing liver inflammation caused by chronic-plus-single-binge ethanol feeding. Additionally, Rk2 improves alcohol-induced intestinal barrier dysfunction by enhancing NLRP6 inflammasome in the intestine.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)