Article
Chemistry, Multidisciplinary
Min Bai, Na Cui, Yucheng Liao, Chao Guo, Liang Li, Ying Yin, Aidong Wen, Jingwen Wang, Weiliang Ye, Yi Ding
Summary: Cerebral ischemia-reperfusion injury (CI/RI) is the main cause of disability and death in stroke. Danshensu (DSS) has anti-inflammatory effects, but its low cellular permeability and bioavailability limit its effectiveness. In this study, a new DSS preparation was developed using liposomes modified with phosphatidylserine (PS) and transferrin (TF) to improve the treatment of ischemic stroke. This formulation can cross the blood-brain barrier and target inflammatory glial cells, reducing inflammation and improving brain injury.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
John W. Constantakis, Catherine A. Reed-McBain, Bolanle Famakin
Summary: Astrocytes are glial cells that play important roles in the healthy brain, including maintaining the blood brain barrier, modulating synaptic transmission and neuronal plasticity, and forming glial scars following ischemic injury. Following ischemia, astrocytes undergo specific changes in phenotype and gene expression, contributing to both the propagation and amelioration of neuronal injury. This review focuses on the dual role of astrocytes and the innate immune system in amplifying secondary brain injury and attenuating ischemic damage, discussing potential molecular signaling and processes that could be targeted for therapeutic interventions.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Dunpeng Cai, Mikayla Fraunfelder, Ken Fujise, Shi-You Chen
Summary: Astrocytes play a critical role in stroke outcomes. This study reveals that ADAR1, an RNA editing enzyme, is highly induced in astrocytes in ischemic stroke lesions, and its deficiency improves stroke outcomes by reducing activated astrocytes and microglia. ADAR1 promotes astrocyte proliferation and induces neuron apoptosis through secretion of inflammatory cytokines.
Article
Cell Biology
Nuttapong Yawoot, Jirakhamon Sengking, Piyawadee Wicha, Piyarat Govitrapong, Chainarong Tocharus, Jiraporn Tocharus
Summary: Melatonin has long-term benefits on cerebral damage after ischemia and reperfusion injury, as it reduces infarct volume, neuronal cell death, reactive astrogliosis, and glial scar formation, while promoting axonal regeneration and neurobehavioral recovery. By inhibiting the activities of GSK-3 beta and RIP1K, melatonin effectively counteracts the deleterious effects due to astrocyte responses and improves functional recovery during the chronic phase of cerebral ischemia and reperfusion injury.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Article
Clinical Neurology
Xia Liu, Qinlian Ye, Zhengzheng Huang, Xiuping Li, Liping Zhang, Xuan Liu, Yun-Cheng Wu, Ulf Brockmeier, Dirk M. Hermann, Ya-Chao Wang, Lijie Ren
Summary: In this study, a switch from UPS to autophagy due to changes in BAG3 expression was observed in cerebral ischemia. BAG3 overexpression activated autophagy and inhibited apoptosis, leading to improved neurological function and reduced ischemic injury.
Article
Plant Sciences
Pei Zhang, Suxin You, Xinyue Ding, Pengwei Luan, Jiazhen Xu, Qianfei Cui, Feiyun Wang, Ruixiang Li, Yuying Zhu, Jiange Zhang
Summary: Musk is a widely used traditional Chinese medicine with resuscitation, activating blood, and disperse swelling effects. This study aimed to investigate the effect and mechanism of muscone in improving ischemic stroke, and verified its efficacy in ischemia-reperfused rats, as well as investigated its mechanism using PC12 and THP-1 cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xiuli Cheng, Jin Hu, Xiaofeng Liu, Jonnea Japhet Tibenda, Xiaobo Wang, Qipeng Zhao
Summary: Traditional Chinese medicine plays a significant role in treating ischemic cardiovascular and cerebrovascular diseases by inhibiting apoptosis. More research is needed on the pharmacodynamic ingredients of TCM.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Haixia Du, Yu He, Jiaqi Zhu, Huifen Zhou, Chongyu Shao, Jiehong Yang, Haitong Wan
Summary: This study found that Danhong injection (DHI) can alleviate cerebral ischemia-reperfusion injury in hyperlipidemia rats. This may be achieved by restoring the mitochondrial respiratory chain and changing the balance of mitochondrial fusion and fission proteins to inhibit mitochondria-dependent apoptosis and improve mitochondrial function.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Wei Li, Xueqi Yang, Mao Ding, Wenjuan Shi, Yuyou Huang, Qi An, Zhifeng Qi, Yongmei Zhao
Summary: This study investigates whether intracellular zinc accumulation aggravates ischemia/reperfusion (I/R) injury through inflammatory response and inflammation-mediated neuronal apoptosis. Results show that cerebral ischemia triggers inflammation, leading to zinc accumulation and neuronal inflammation. Chelation of zinc reverses neuronal inflammation and apoptosis. Excessive zinc activation of inflammation contributes to brain injury, specifically through inflammation-induced neuronal apoptosis, providing an important mechanism for cerebral I/R injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Jin Yang, Lu-Lu Cao, Xi-Peng Wang, Wei Guo, Ruo-Bing Guo, Yu-Qin Sun, Teng-Fei Xue, Zhen-Yu Cai, Juan Ji, Hong Cheng, Xiu-Lan Sun
Summary: The study demonstrates the protective role of miR-98 in ischemic stroke by inhibiting microglial phagocytosis to reduce neuronal death. Neurons transfer miR-98 to microglia via EVs secretion to prevent phagocytosis of stressed-but-viable neurons.EVs derived miR-98 act as an intercellular signal mediating neurons and microglia communication during brain remodeling after ischemic stroke.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Egor Y. Plotnikov, Ilya V. Baimler, Sergey V. Gudkov, Egor A. Turovsky
Summary: This study demonstrates the cytoprotective properties of the trace element selenium, its nanoparticles, and selenium nanocomplexes with active compounds. It shows that spherical selenium nanoparticles can protect brain cells during ischemia/reoxygenation, and their effectiveness is dependent on factors such as diameter and pathways of penetration into astrocytes. The research also highlights the potential advantages of studying and utilizing nanorods as nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Lina Zhao, Huanming Li, Qian Gao, Jin Xu, Yongjie Zhu, Meili Zhai, Peijun Zhang, Na Shen, Yanbo Di, Jinhui Wang, Tie Chen, Meina Huang, Jinglai Sun, Chong Liu
Summary: Berberine exerts neuroprotective effects against ischemic stroke by inhibiting neuronal apoptosis induced by CIRI through downregulating the CNPY2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Qian Xu, Guohui Ma, Dandan Li, Fanghui Bai, Jintao Fang, Gui Zhang, Yuxin Xing, Jiawei Zhou, Yugang Guo, Yunchao Kan
Summary: This study elucidated the involvement of C2dat2 in regulating autophagy and apoptosis induced by CIRI, by inhibiting miR-30d-5p through a ceRNA mechanism, affecting the DDIT4/mTOR pathway. This contributes to a better understanding of the mechanisms of CIRI.
Article
Plant Sciences
Yue Yang, Huan Gao, Wenwu Liu, Xin Liu, Xiaowen Jiang, Xiang Li, Qiong Wu, Zihua Xu, Qingchun Zhao
Summary: The study demonstrates that Arctium lappa L. roots protect against cerebral ischemia by inhibiting apoptosis and AMPK/mTOR-mediated autophagy in in vitro and in vivo, providing a theoretical basis for the development of CQAs in Arctium lappa L. roots as neuroprotective drugs for the prevention and treatment of ischemic stroke.
Article
Neurosciences
Xiaofei Zhou, Jonathan Pace, Emily Filichia, Tao Lv, Brandon Davis, Barry Hoffer, Warren Selman, Yu Luo
EXPERIMENTAL NEUROLOGY
(2016)
Review
Cell Biology
Tao Lu, Paul Kim, Yu Luo
NEURAL REGENERATION RESEARCH
(2017)
Article
Neurosciences
Tao Lu, Paul P. Kim, Nigel H. Greig, Yu Luo
NEUROTOXICITY RESEARCH
(2017)
Article
Clinical Neurology
Yongming Jin, Austin Barnett, Yifan Zhang, Xin Yu, Yu Luo
Article
Cell & Tissue Engineering
Flavia Turcato, Paul Kim, Austin Barnett, Yongming Jin, Mike Scerba, Anthony Casey, Warren Selman, Nigel H. Greig, Yu Luo
CELL TRANSPLANTATION
(2018)
Article
Biochemistry & Molecular Biology
Shih-Chang Hsueh, Kai-Yun Chen, Jing-Huei Lai, Chung-Che Wu, Yu-Wen Yu, Yu Luo, Tsung-Hsun Hsieh, Yung-Hsiao Chiang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Clinical Neurology
Di Hu, Xiaoyan Sun, Xudong Liao, Xinwen Zhang, Sara Zarabi, Aaron Schimmer, Yuning Hong, Christopher Ford, Yu Luo, Xin Qi
ACTA NEUROPATHOLOGICA
(2019)
Review
Neurosciences
Fucheng Luo, Zhen Zhang, Austin Barnett, Tania J. Bellinger, Flavia Turcato, Kelly Schmidt, Yu Luo
EXPERIMENTAL NEUROLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuning Gu, Huiyun Gao, Kihwan Kim, Yuchi Liu, Ciro Ramos-Estebanez, Yu Luo, Yunmei Wang, Xin Yu
Summary: In this study, a high-resolution 3D O-17 MRI method was developed to monitor the dynamics of O-17 signal changes in the mouse brain. The method achieved an isotropic resolution of 1.21 mm and can be utilized to quantify physiological parameters and measure oxygen consumption rate.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Fucheng Luo, Zhen Zhang, Yu Luo
Summary: In specific brain injuries, p53 deficiency in oligodendrocytes provides protection against demyelination and functional impairment, suggesting that p53 may play different roles in different brain regions or in response to various stresses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Alicia Bedolla, Aleksandr Taranov, Fucheng Luo, Jiapeng Wang, Flavia Turcato, Elizabeth M. Fugate, Nigel H. Greig, Diana M. Lindquist, Steven A. Crone, June Goto, Yu Luo
Summary: Comparing two models of microglia ablation, it was found that the genetic ablation model displayed a rapid pathological condition in the brain, while the pharmacological ablation model did not. The results revealed that the CSF/ventricular space shrinkage pathology in the genetic ablation model is caused by the iDTR allele, independent of brain edema formation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Pierce Boyne, Oluwole O. Awosika, Yu Luo
Summary: The study mapped the corticoreticular pathway (CRP) in mice and compared it with the corticospinal tract (CST). It found that CRP had significant projections originating from various motor and sensory cortices, with stronger projections compared to CST in most regions. Ipsilateral projections were stronger than contralateral for both tracts, but CRP projected more bilaterally than CST.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Review
Chemistry, Medicinal
Elliot J. Glotfelty, Thomas E. Delgado, Luis B. Tovar-y-Romo, Yu Luo, Barry J. Hoffer, Lars Olson, Tobias E. Karlsson, Mark P. Mattson, Brandon K. Harvey, David Tweedie, Yazhou Li, Nigel H. Greig
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2019)
Article
Neurosciences
Cheng-Fu Chang, Jing-Huei Lai, John Chung-Che Wu, Nigel H. Greig, Robert E. Becker, Yu Luo, Yen-Hua Chen, Shuo-Jhen Kang, Yung-Hsiao Chiang, Kai-Yun Chen
Review
Cell & Tissue Engineering
Dong Seok Kim, Ho-Il Choi, Yun Wang, Yu Luo, Barry J. Hoffer, Nigel H. Greig
CELL TRANSPLANTATION
(2017)