Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 29, Issue 7, Pages 1320-1326Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gft484
Keywords
cell alignment; glomerular filtration barrier; kidney development; polycystic kidney disease; ureteric bud branching
Categories
Funding
- Wellcome Trust
- Kidney Research UK
- MRC
- Wellcome Trust [087525]
- MRC [G0801124]
- MRC [MR/J003638/1, G0801124] Funding Source: UKRI
- Kidney Research UK [SF1/2008] Funding Source: researchfish
- Medical Research Council [MR/J003638/1, G0801124] Funding Source: researchfish
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Planar cell polarity (PCP) is the uniform orientation and alignment of a group of cells orthogonal to the apical-basal axis within a tissue. Originally described in insects, it is now known that PCP is required for many processes in vertebrates, including directional cell movement, polarized cell division, ciliary orientation, neural tube closure, heart development and lung branching. In this review, we outline the evidence implicating PCP in kidney development and disease focusing initially on the function of PCP in ureteric bud branching and elongation. We then describe how defects in PCP may lead to polycystic kidney disease and discuss a newly identified role for PCP in the kidney filtration barrier.
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