Article
Multidisciplinary Sciences
Pinxue Xie, Qisheng You, Jiang Zhu, Wuxiang Xie, Ping Wei, Siquan Zhu, Yunhui Du, Xinxiao Gao
Summary: This study aimed to investigate the role of PDLIM1 on retinal vascular endothelial cells in diabetic retinopathy (DR). The results showed that PDLIM1 was mainly expressed in specific layers of the retina and played a protective role in DR by negatively regulating Wnt3a, improving cell apoptosis, migration, and invasion. Therefore, PDLIM1 might be a promising therapeutic target for DR treatment.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jie Zhang, Yijun Yang, Xinhua Li, Gen Li, Takuya Mizukami, Yanli Liu, Yuan Wang, Guoqiang Xu, Heinrich Roder, Li Zhang, Zeng-jie Yang
Summary: PDLIM3 plays a crucial role in ciliogenesis and hedgehog signaling transduction in SHH-MB cells, promoting cell proliferation and tumor growth. It can serve as a molecular marker for defining MB.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
M. Quadir Siddiqui, Maulik D. Badmalia, Trushar R. Patel
Summary: Through bioinformatic analysis, it was found that Zyxin family members may have nuclear and cytoplasmic roles, and may possess previously unanticipated nucleic acid binding properties. The intrinsic dynamics of LIM domains also differ among members. These proteins play important roles in mediating protein-protein and protein-nucleic acid interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Yingjun Liu, Wenkuan Wang, Jintao Zhang, Shuo Gao, Tingting Xu, Yonghui Yin
Summary: This review examines the imbalance of the Janus kinase/signal transducer and activator of the transcription (JAK/STAT) signaling pathway in diabetic kidney disease (DKD) and its role in the progression of kidney disease. It also discusses the potential of the JAK/STAT pathway as a target for treating DKD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Yuqing Zhang, De Jin, Xiaomin Kang, Rongrong Zhou, Yuting Sun, Fengmei Lian, Xiaolin Tong
Summary: The review discusses the pathological mechanisms of diabetic renal fibrosis and related signaling pathways to provide novel therapeutic intervention insights for clinical research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Martin Siegemund, Prajakta Oak, Eva-Maria Hansbauer, Andrea Allersdorfer, Karoline Utschick, Alexandra Winter, Christina Grasmueller, Gunther Galler, Jan-Peter Mayer, Benjamin Weiche, Josef Prassler, Roland E. Kontermann, Christine Rothe
Summary: ABD and IgBD have been investigated for extending the plasma half-life of Anticalin proteins. ABD fusion proteins showed higher affinity and longer half-life, with Anti-OX40 Anticalin-ABD demonstrating significantly extended half-life in mice. Both ABD and IgBD fusions exhibited appropriate functional properties in therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sih Min Tan, Matthew Snelson, Jakob A. Ostergaard, Melinda T. Coughlan
Summary: The pathogenesis of diabetic kidney disease (DKD) involves disrupted energy generation in the kidney, leading to inflammation and fibrosis. Recent studies have shown the involvement of the innate immune complement system, particularly Complement C5a and C3a, in regulating metabolic responses in the diabetic kidney.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Multidisciplinary Sciences
William Dion, Heather Ballance, Jane Lee, Yinghong Pan, Saad Irfan, Casey Edwards, Michelle Sun, Jing Zhang, Xin Zhang, Silvia Liu, Bokai Zhu
Summary: This study identified a cell-autonomous 12-hour ultradian rhythm mechanism in mammals that is separate from the 24-hour circadian clock and the cell cycle. By modulating the temporal dynamics of proteostasis, the nuclear speckle LLPS may represent a previously unidentified therapeutic target for pathologies associated with dysregulated proteostasis.
Review
Pharmacology & Pharmacy
Kensei Taguchi, Kei Fukami
Summary: Diabetes, a leading cause of death worldwide, is expected to affect 642 million people by 2040. The concept of diabetic kidney disease (DKD) is widely accepted due to the increasing number of diabetes patients with multiple underlying diseases. Receptor for advanced glycation endproducts (RAGE), a multiligand receptor, is upregulated in patients with diabetes, hypertension, obesity, and chronic inflammation, and can be a therapeutic target for inhibiting the progression of DKD and its complications.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Filip Tichanek, Asta Foersti, Akseli Hemminki, Otto Hemminki, Kari Hemminki
Summary: Cancers in the urinary bladder and kidney have shown improved survival rates in the Nordic countries and other countries as well. The survival rate for kidney cancer has tripled in 50 years, with 75% of patients surviving 5 years. Bladder cancer survival is still better than kidney cancer survival, especially in men, but female kidney cancer survival has caught up with that of bladder cancer.
Article
Immunology
Wencui Wan, Yang Long, Xuemin Jin, Qiuming Li, Weiwei Wan, Hongzhuo Liu, Yu Zhu
Summary: This study demonstrated that miR-200a may serve as a potential therapeutic target in DR through down-regulating PDLIM1, significantly affecting cell viability and inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jiamei Wu, Kai Zhao, Zengmin Du, Ying Chen, Feixu Zhang, Wei Jiang, Jing Zheng, Xia Wu, Chengyong Shen, Xiao Xiao
Summary: FHL1 is a scaffold protein that mutations have been linked to various muscular diseases, causing muscle loss and nervous system issues. In myotubes, loss of Fhl1 affects AChR clustering and myotube fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
P. Maria Clemente-Olivo, J. Jayron Habibe, Mariska Vos, Roelof Ottenhoff, Aldo Jongejan, Hilde Herrema, Noam Zelcer, Sander Kooijman, Patrick C. N. Rensen, Daniel H. van Raalte, Max Nieuwdorp, Etto C. Eringa, J. Carlie de Vries
Summary: The study reveals that the FHL2 gene is associated with obesity and energy metabolism. FHL2 deficiency protects mice from high-fat diet-induced weight gain while glucose handling remains normal. Enhanced energy expenditure was observed in multiple tissues.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Cell Biology
Mansour Alkobtawi, Patrick Pla, Anne H. Monsoro-Burq
Summary: Fhl3 protein modulates BMP signaling interpretation during neural crest induction, facilitating neural crest formation.
Article
Plant Sciences
Marija Smokvarska, Yvon Jaillais, Alexandre Martiniere
Summary: The interaction between different molecular partners in a crowded environment can be time-consuming, which is solved by the biological membrane with its fluidity and compartmentalized domains. The nanoscale organization of membranes based on weak, local, and multivalent interactions between lipids and proteins plays a critical role in regulating cellular signaling. The small GTPase enzymes Rho of Plant (ROP) are involved in various signaling pathways and cellular properties, with their association with the membrane essential for their function and precise targeting within polar and nanoscale domains.
Article
Chemistry, Multidisciplinary
Yen-Ting Lai, Chien-Hung Lin, City C. Hsieh, Jung-Cheng Yang, Han-Hsing Tsou, Chih-Ching Lin, Szu-Yuan Li, Hsiang-Lin Chan, Wen-Sheng Liu
Summary: The combination of yoga and standard stroke rehabilitation has the potential to improve depression and balance in patients. Factors such as sex, brain lesion site, and age may influence the effectiveness of the treatment.
APPLIED SCIENCES-BASEL
(2022)
Article
Cardiac & Cardiovascular Systems
Yi-Hsin Chan, Tze-Fan Chao, Shao-Wei Chen, Yi-Wei Kao, Chien-Ying Huang, Pao-Hsien Chu
Summary: This study aimed to investigate the frequency and clinical implications of sCr increase following SGLT2i treatment in patients with type 2 diabetes. The results showed that a modest increase in sCr (<30%) was common and not associated with worse clinical outcomes, indicating that therapy should not be prematurely stopped.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Medicine, General & Internal
Fu-Chih Hsiao, Chien-Te Ho, Chia -Pin Lin, Chiu-Yi Hsu, Chi-Jen Chang, Pao-Hsien Chu
Summary: This study investigated the impact of revascularization on long-term survival and renal outcome in NSTEMI patients with severe CKD. The results showed that revascularization was associated with a lower risk of all-cause mortality in severe CKD patients, but it increased the risk of progression to chronic hemodialysis in non-dialysis-dependent patients.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Oncology
Shing-Hsien Chou, Chia-Pin Lin, Yu-Sheng Lin, Ting-Hein Lee, Chan-Keng Yang, Yu-Sheng Lin, Pao-Hsien Chu
Summary: There is an association between acute myocardial infarction (AMI) and colon cancer, but it varies by gender and age. Female patients with AMI have a higher risk of colon cancer, especially those aged 65 and above.
Article
Gastroenterology & Hepatology
Ying-Chang Tung, Fu-Chih Hsiao, Chia-Pin Lin, Chien-Te Ho, Tzyy-Jer Hsu, Hou-Yu Chiang, Pao-Hsien Chu
Summary: High triglyceride variability is associated with an increased risk of acute pancreatitis, independent of baseline and mean triglyceride levels, and this association may be mediated by subclinical inflammation.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Environmental Sciences
Yen-Ting Lai, Hsiao-Ling Huang, City C. C. Hsieh, Chien-Hung Lin, Jung-Cheng Yang, Han-Hsing Tsou, Chih-Ching Lin, Szu-Yuan Li, Hsiang-Lin Chan, Wen-Sheng Liu
Summary: This study investigated the beneficial effects of adding yoga to rehabilitation on blood pressure and hand grip strength in chronic stroke patients. The results showed that combining yoga with rehabilitation led to a significant decrease in systolic blood pressure and improvements in hand grip strength. The control group, which received only standard rehabilitation, did not show significant changes in blood pressure or hand grip strength.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Urology & Nephrology
Yi-Hsin Chan, Tze-Fan Chao, Shao-Wei Chen, Yi-Wei Kao, Chien-Ying Huang, Pao-Hsien Chu
Summary: This study aimed to investigate whether background medications modify the effects of SGLT2 inhibitor on eGFR and kidney outcomes in patients with type 2 diabetes. The results showed that background use of renin-angiotensin inhibitor and loop diuretics was associated with a larger initial decline in eGFR, while background use of metformin was associated with a smaller initial decline in eGFR. Except for renin-angiotensin system inhibitor with favorable outcomes and loop diuretics with worse composite kidney outcomes, most medications were not associated with long-term kidney outcomes in patients treated with SGLT2 inhibitor.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Food Science & Technology
Shing-Hsien Chou, Hung-Chen Lin, Shao-Wei Chen, Yu-Ting Tai, Shih-Ming Jung, Fu-Hsiang Ko, Jong-Hwei Su Pang, Pao-Hsien Chu
Summary: This study examines the effects of cadmium exposure on the cardiac and arterial systems in mice. It finds that cadmium exposure leads to damage in the heart tissues and artery tissues, which may contribute to cardiovascular diseases.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biophysics
Kuo-An Hung, Yi-Wei Hsu, Yu-Cheng Chen, Tzu-Ping Lin
Summary: High temperatures have become common in cities and agricultural areas in Taiwan, especially affecting the city of Tainan, which relies on agriculture as its primary industry. The study focuses on asparagus cultivation in greenhouses and explores the optimal growth environment using drip irrigation with temperature adjustment. The findings show a correlation between asparagus yield and temperature/soil moisture content, and implementing the drip irrigation system can save water and increase average yield.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Article
Biophysics
Shing-Ru Yang, Shih-Tang Lan, Yi-Ting Wu, Tsuyoshi Honjo, Tzu-Ping Lin
Summary: This study examined the use of expanded metal meshes (EMMs) in horizontal shading devices. Simulations and experiments were conducted with EMMs of varying opening ratios and directions. Data on air temperature, surface temperature, and black globe temperature were collected from different experimental and control groups. Simulation results using Grasshopper were used to analyze long-term climate conditions and provide customized suggestions for users in Tainan. The findings can serve as a benchmark for parametric design analysis of EMMs and be applied in the design phase of outdoor horizontal shading devices. It was found that EMMs with small openings provided effective shading effects throughout the day. North-facing EMMs are recommended in the Tainan area, as they blocked 70% of sunshine in our simulations. West-facing EMMs are suitable for morning shading, blocking 50-90% of sunshine. East-facing EMMs can block 50-90% of sunshine after noon, making them ideal for recreational areas in the afternoon and evening. South-facing EMMs are not advised in Taiwan due to their suboptimal shading performance in the morning and afternoon.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Article
Endocrinology & Metabolism
Fu-Chih Hsiao, Yi-Hsin Chan, Ying-Chang Tung, Chia-Pin Lin, Ting-Hein Lee, Yu-Chiang Wang, Pao-Hsien Chu
Summary: This study found that glycemic variation is associated with diabetes and may lead to various complications. The investigation focused on the association between visit to visit hemoglobin A1c (HbA1c) variation and the long-term risk of major adverse limb events (MALEs). The results showed that patients with high HbA1c variation have an increased risk of MALEs and lower limb amputation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Chien-Chia Wu, Chien-Hao Huang, Chun-Li Wang, Meng-Hung Lin, Ting-Yu Kuo, Chih-Hsiang Chang, Michael Wu, Shao-Wei Chen, Shang-Hung Chang, Pao-Hsien Chu, Cheng-Shyong Wu, Yu-Sheng Lin
Summary: This study aimed to investigate the impact of direct acting antiviral (DAA) treatment on HCV-associated cardiovascular events. The results showed that patients treated with DAA had significantly lower rates of heart failure, venous thromboembolism, major adverse cardiovascular events, and all-cause mortality. The reduction of venous thromboembolism was the most significant impact of DAA treatment among the cardiovascular outcomes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Cze Ci Chan, Ying-Chang Tung, Kuang-Tso Lee, Yi-Hsin Chan, Pao-Hsien Chu
Summary: This study found that generic clopidogrel is comparable to its brand-name counterpart for the treatment of patients with acute myocardial infarction, with similar cardiovascular and bleeding outcomes.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Dong-Yi Chen, Cheng-Hung Lee, Ming-Lung Tsai, Ming-Jer Hsieh, Cheng-Keng Chuang, See-Tong Pang, Shao-Wei Chen, Chi-Nan Tseng, Shang-Hung Chang, Pao-Hsien Chu, I-Chang Hsieh, Victor Chien-Chia Wu, Wen-Kuan Huang
Summary: This study aimed to investigate the risk of cardiac dysfunction in prostate cancer patients undergoing ADT. The study found that patients undergoing ADT had a decline in LVEF, and lower baseline LVEF was significantly associated with CT-RCD. This has important implications for prostate cancer patients undergoing ADT.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Obstetrics & Gynecology
Liang-Hsuan Chen, Chia-Pin Lin, Hsien-Ming Wu, Po-Hsien Chu
Summary: This study investigated the association between post-occlusive reactive hyperaemia (PORH) and ovarian stimulation in normoandrogenic women with polycystic ovary syndrome (PCOS). The results showed that the PCOS group had higher levels of C-reactive protein and insulin resistance. There was no significant difference in microcirculatory function between the groups at baseline, but after ovarian stimulation, the control group showed enhanced PORH while the PCOS group exhibited a blunting response. This suggests that normoandrogenic women with PCOS undergoing IVF may experience early changes in vascular endothelial dysfunction. Further observational studies are needed to determine if PORH measurement can predict IVF prognosis or obstetric complications.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)