Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis

The retinoid derivant ECPIRM selectively exhibited anti-proliferation effects in Cutaneous T-Cell Lymphoma via ITK-mediated signaling pathway

(2020) Hongyang Li et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine

(2019) Hyoung-Soo Cho et al.   Nature Communications

Discovery of 7H-pyrrolo[2,3-d]pyrimidine derivatives as selective covalent irreversible inhibitors of interleukin-2-inducible T-cell kinase (Itk)

(2019) Guanghui Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inherited Interleukin 2–Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma

(2019) Leila Youssefian et al.   CLINICAL INFECTIOUS DISEASES

ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

(2019) Yalu Liu et al.   Cancer Cell International

PF-06651600, a dual JAK3/TEC family kinase inhibitor

(2019) Hua Xu et al.   ACS Chemical Biology

Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells

(2019) Ahmet Eken et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Inhibition of Bruton’s tyrosine kinase and IL-2 inducible T-cell kinase suppresses both neutrophilic and eosinophilic airway inflammation in a cockroach allergen extract-induced mixed granulocytic mouse model of asthma using preventative and therapeutic strategy

(2019) Ahmed Nadeem et al.   PHARMACOLOGICAL RESEARCH

ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis

(2018) Jessica M. Fuhriman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interleukin-2-Inducible T-Cell Kinase Deficiency—New Patients, New Insight?

(2018) Sujal Ghosh et al.   Frontiers in Immunology

Human immunity against EBV—lessons from the clinic

(2017) Stuart G. Tangye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+CTLs

(2017) Senta M. Kapnick et al.   JOURNAL OF IMMUNOLOGY

ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells

(2017) Weishan Huang et al.   Nature Communications

T Cell Receptor-induced Nuclear Factor κB (NF-κB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry

(2016) Xiaohong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

(2016) Julio Gomez-Rodriguez et al.   Nature Communications

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

(2015) C. C. Carson et al.   CLINICAL CANCER RESEARCH

Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

(2015) Yiming Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression

(2015) Hyoung-Soo Cho et al.   JOURNAL OF IMMUNOLOGY

Itk Signals Promote Neuroinflammation by Regulating CD4+ T-Cell Activation and Trafficking

(2015) A. K. Kannan et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

(2015) Yonglian Sun et al.   Science Signaling

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

(2015) Yonglian Sun et al.   Science Signaling

Intracellular TCR-signaling Pathway

(2014) Claudio Agostinelli et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective Expression Rather than Specific Function of Txk and Itk Regulate Th1 and Th2 Responses

(2014) N. Sahu et al.   JOURNAL OF IMMUNOLOGY

Differential Sensitivity to Itk Kinase Signals for T Helper 2 Cytokine Production and Chemokine-Mediated Migration

(2014) N. Sahu et al.   JOURNAL OF IMMUNOLOGY

The Tec Kinases Itk and Rlk Regulate NKT Cell Maturation, Cytokine Production, and Survival

(2014) M. Felices et al.   JOURNAL OF IMMUNOLOGY

IL-2–Inducible T Cell Kinase Tunes T Regulatory Cell Development and Is Required for Suppressive Function

(2014) Weishan Huang et al.   JOURNAL OF IMMUNOLOGY

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

(2013) J. A. Dubovsky et al.   BLOOD

Primary immunodeficiencies predisposed to Epstein-Barr virus-driven haematological diseases

(2013) Nima Parvaneh et al.   BRITISH JOURNAL OF HAEMATOLOGY

Current and Emerging Therapies in Mantle Cell Lymphoma

(2013) L. Kyle Brett et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

IL-2–inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells

(2013) Arun K. Kannan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765)

(2013) Jan A. Burger et al.   LEUKEMIA & LYMPHOMA

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Inhibitors of BTK and ITK: State of the New Drugs for Cancer, Autoimmunity and Inflammatory Diseases

(2013) L. Vargas et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Ibrutinib (PCI-32765), the First BTK (Bruton’s Tyrosine Kinase) Inhibitor in Clinical Trials

(2013) Jennifer R. Brown   Current Hematologic Malignancy Reports

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

(2012) Y.-T. Tai et al.   BLOOD

Clinicopathologic Characteristics of Angioimmunoblastic T-Cell Lymphoma: Analysis of the International Peripheral T-Cell Lymphoma Project

(2012) Massimo Federico et al.   JOURNAL OF CLINICAL ONCOLOGY

A Unique Role for ITK in Survival of Invariant NKT Cells Associated with the p53-Dependent Pathway in Mice

(2012) Q. Qi et al.   JOURNAL OF IMMUNOLOGY

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

(2012) R M Linka et al.   LEUKEMIA

Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates

(2011) Julio Gomez-Rodriguez et al.   FEBS Journal

Tec family kinases: regulation of FcεRI-mediated mast-cell activation

(2011) Wilfried Ellmeier et al.   FEBS Journal

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

(2011) Samuel Huber et al.   IMMUNITY

The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells

(2011) Betty Y Chang et al.   ARTHRITIS RESEARCH & THERAPY

Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases

(2010) Arne von Bonin et al.   EXPERIMENTAL DERMATOLOGY

Itk inhibitors: a patent review

(2010) Ho Yin Lo   EXPERT OPINION ON THERAPEUTIC PATENTS

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

(2010) Konstanze Pechloff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

(2010) Douglas J. Marcotte et al.   PROTEIN SCIENCE

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

ITK Inhibitors in Inflammation and Immune-Mediated Disorders

(2009) Nisebita Sahu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

(2009) Julio Gomez-Rodriguez et al.   IMMUNITY

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials

(2008) N. Mourad et al.   BLOOD

International Peripheral T-Cell and Natural Killer/T-Cell Lymphoma Study: Pathology Findings and Clinical Outcomes

(2008)   JOURNAL OF CLINICAL ONCOLOGY