A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression

Allele-sensitive mutant, Itkas, reveals that Itk kinase activity is required for Th1, Th2, Th17, andiNKT-cell cytokine production

(2015) Arun Kannan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

(2015) Yiming Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

(2015) Stacey N. Harbour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective Expression Rather than Specific Function of Txk and Itk Regulate Th1 and Th2 Responses

(2014) N. Sahu et al.   JOURNAL OF IMMUNOLOGY

IL-2–Inducible T Cell Kinase Tunes T Regulatory Cell Development and Is Required for Suppressive Function

(2014) Weishan Huang et al.   JOURNAL OF IMMUNOLOGY

CD28 and ITK signals regulate autoreactive T cell trafficking

(2013) Nitya Jain et al.   NATURE MEDICINE

Gut-Tropic T Cells That Express Integrin α4β7 and CCR9 Are Required for Induction of Oral Immune Tolerance in Mice

(2011) Barbara Cassani et al.   GASTROENTEROLOGY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production

(2011) T. Feng et al.   JOURNAL OF IMMUNOLOGY

Memory CCR6+CD4+ T Cells Are Preferential Targets for Productive HIV Type 1 Infection Regardless of Their Expression of Integrin  7

(2011) P. Monteiro et al.   JOURNAL OF IMMUNOLOGY

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

5-Aminomethylbenzimidazoles as potent ITK antagonists

(2009) Doris Riether et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ITK Inhibitors in Inflammation and Immune-Mediated Disorders

(2009) Nisebita Sahu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

(2009) Julio Gomez-Rodriguez et al.   IMMUNITY

A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells

(2009) Aixin Yu et al.   IMMUNITY

The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut

(2009) C Wang et al.   Mucosal Immunology

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

Tec kinase Itk in   T cells is pivotal for controlling IgE production in vivo

(2009) M. Felices et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA