Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo

(2015) Jason D. Burch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective Expression Rather than Specific Function of Txk and Itk Regulate Th1 and Th2 Responses

(2014) N. Sahu et al.   JOURNAL OF IMMUNOLOGY

Differential Sensitivity to Itk Kinase Signals for T Helper 2 Cytokine Production and Chemokine-Mediated Migration

(2014) N. Sahu et al.   JOURNAL OF IMMUNOLOGY

Naive and Innate Memory Phenotype CD4+ T Cells Have Different Requirements for Active Itk for Their Development

(2014) J. Hu et al.   JOURNAL OF IMMUNOLOGY

The Tec Kinases Itk and Rlk Regulate NKT Cell Maturation, Cytokine Production, and Survival

(2014) M. Felices et al.   JOURNAL OF IMMUNOLOGY

IL-2–Inducible T Cell Kinase Tunes T Regulatory Cell Development and Is Required for Suppressive Function

(2014) Weishan Huang et al.   JOURNAL OF IMMUNOLOGY

A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production

(2014) Laura J Simpson et al.   NATURE IMMUNOLOGY

Characterisation of a K390R ITK Kinase Dead Transgenic Mouse – Implications for ITK as a Therapeutic Target

(2014) Angela Deakin et al.   PLoS One

Disconnect between sputum neutrophils and other measures of airway inflammation in asthma

(2013) J. R. Arron et al.   EUROPEAN RESPIRATORY JOURNAL

CD28 and ITK signals regulate autoreactive T cell trafficking

(2013) Nitya Jain et al.   NATURE MEDICINE

Regulation of T-cell Responses and Disease by Tec Kinase Itk

(2012) Avery August et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

(2012) Guiquan Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates

(2011) Julio Gomez-Rodriguez et al.   FEBS Journal

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Independent filtering increases detection power for high-throughput experiments

(2010) R. Bourgon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk

(2009) Julie A. Readinger et al.   IMMUNOLOGICAL REVIEWS

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION