ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

Expression of T-cell receptor signalling pathway components in extranodal NK/T-cell lymphoma

(2018) Tomoko Miyata-Takata et al.   HISTOPATHOLOGY

NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling

(2018) Sonja M. Lacher et al.   JOURNAL OF AUTOIMMUNITY

Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis

(2018) Brittelle E. Kessler et al.   ONCOGENE

Novel selective TOPK inhibitor SKLB-C05 inhibits colorectal carcinoma growth and metastasis

(2018) Tiantao Gao et al.   CANCER LETTERS

FAK inhibitors in Cancer, a patent review

(2017) Peng-Cheng Lv et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin

(2017) Maria Pamela Dobay et al.   HAEMATOLOGICA

Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma

(2017) M Fujisawa et al.   LEUKEMIA

Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB

(2017) A García-Mariscal et al.   ONCOGENE

Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin

(2017) Maria Pamela Dobay et al.   HAEMATOLOGICA

Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas

(2016) D. Vallois et al.   BLOOD

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

(2016) S. H. Swerdlow et al.   BLOOD

T-cell Receptor Signaling Activates an ITK/NF-κB/GATA-3 axis in T-cell Lymphomas Facilitating Resistance to Chemotherapy

(2016) Tianjiao Wang et al.   CLINICAL CANCER RESEARCH

The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma

(2016) T Muramatsu et al.   ONCOGENE

Drug Combination Studies and Their Synergy Quantification Using the Chou–Talalay Method—Letter

(2015) John C. Ashton   CANCER RESEARCH

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

(2015) C. C. Carson et al.   CLINICAL CANCER RESEARCH

Targeting BAG-1: A novel strategy to increase drug efficacy in acute myeloid leukemia

(2015) Sanja Aveic et al.   EXPERIMENTAL HEMATOLOGY

Multistep tumorigenesis in peripheral T cell lymphoma

(2015) Mamiko Sakata-Yanagimoto   INTERNATIONAL JOURNAL OF HEMATOLOGY

Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

(2015) Yiming Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recurrent activating mutations of CD28 in peripheral T-cell lymphomas

(2015) J Rohr et al.   LEUKEMIA

Intracellular TCR-signaling Pathway

(2014) Claudio Agostinelli et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Peripheral T cell lymphoma in Asia

(2014) Sanghui Park et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia

(2013) R. M. A. Linger et al.   BLOOD

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

(2013) J. A. Dubovsky et al.   BLOOD

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs

(2012) Christopher T. Saunders et al.   BIOINFORMATICS

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

(2012) F. Lemonnier et al.   BLOOD

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma

(2012) R. A. Cairns et al.   BLOOD

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Up-Front Autologous Stem-Cell Transplantation in Peripheral T-Cell Lymphoma: NLG-T-01

(2012) Francesco d'Amore et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinicopathologic Characteristics of Angioimmunoblastic T-Cell Lymphoma: Analysis of the International Peripheral T-Cell Lymphoma Project

(2012) Massimo Federico et al.   JOURNAL OF CLINICAL ONCOLOGY

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

(2011) Valentina Boeva et al.   BIOINFORMATICS

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

(2011) Cyril Quivoron et al.   CANCER CELL

Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates

(2011) Julio Gomez-Rodriguez et al.   FEBS Journal

Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group

(2010) N. Schmitz et al.   BLOOD

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

(2010) Konstanze Pechloff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

ITK Inhibitors in Inflammation and Immune-Mediated Disorders

(2009) Nisebita Sahu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Syk protein tyrosine kinase induces apoptosis and blocks proliferation in T-cell non-Hodgkin's lymphoma cell lines

(2009) R A Wilcox et al.   LEUKEMIA

Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials

(2008) N. Mourad et al.   BLOOD

International Peripheral T-Cell and Natural Killer/T-Cell Lymphoma Study: Pathology Findings and Clinical Outcomes

(2008)   JOURNAL OF CLINICAL ONCOLOGY

Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas

(2008) A L Feldman et al.   LEUKEMIA