Interleukin-2-Inducible T-Cell Kinase Deficiency—New Patients, New Insight?

Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency

(2017) Chiara Bacchelli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human immunity against EBV—lessons from the clinic

(2017) Stuart G. Tangye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+CTLs

(2017) Senta M. Kapnick et al.   JOURNAL OF IMMUNOLOGY

Course of IL-2-inducible T-cell kinase deficiency in a family: lymphomatoid granulomatosis, lymphoma and allogeneic bone marrow transplantation in one sibling; and death in the other

(2016) D Çağdaş et al.   BONE MARROW TRANSPLANTATION

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT

(2016) Baerbel Keller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

(2016) Elisabeth Salzer et al.   NATURE IMMUNOLOGY

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

(2016) Julio Gomez-Rodriguez et al.   Nature Communications

High incidence of Epstein-Barr virus (EBV)-positive Hodgkin lymphoma and Hodgkin lymphoma-like B-cell lymphoproliferations with EBV latency profile 2 in children with interleukin-2-inducible T-cell kinase deficiency

(2015) Kirsten Bienemann et al.   HISTOPATHOLOGY

Atypical Clinical Course in Pediatric Hodgkin Lymphoma

(2015) Charlotte Alme et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

ITK Deficiency: How can EBV be Treated Before Lymphoma?

(2015) Funda Erol Cipe et al.   PEDIATRIC BLOOD & CANCER

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

(2015) S. Okada et al.   SCIENCE

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

(2015) Yonglian Sun et al.   Science Signaling

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

(2015) Yonglian Sun et al.   Science Signaling

Identification of ITK deficiency as a novel genetic cause of idiopathic CD4+ T-cell lymphopenia

(2014) N. K. Serwas et al.   BLOOD

Interleukin-2-Inducible T-Cell Kinase (ITK) Deficiency - Clinical and Molecular Aspects

(2014) Sujal Ghosh et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Tec Kinases Itk and Rlk Regulate NKT Cell Maturation, Cytokine Production, and Survival

(2014) M. Felices et al.   JOURNAL OF IMMUNOLOGY

Innate immune control of EBV-infected B cells by invariant natural killer T cells

(2013) B. K. Chung et al.   BLOOD

Primary immunodeficiencies predisposed to Epstein-Barr virus-driven haematological diseases

(2013) Nima Parvaneh et al.   BRITISH JOURNAL OF HAEMATOLOGY

IL-2–inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells

(2013) Arun K. Kannan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-2-Inducible T-Cell Kinase Deficiency with Pulmonary Manifestations due to Disseminated Epstein-Barr Virus Infection

(2012) D. Mansouri et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Tec Family Kinases in Inflammation and Disease

(2012) Nicole J. Horwood et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

(2012) R M Linka et al.   LEUKEMIA

TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation

(2012) R. Nayar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TEC family kinases in health and disease - loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK

(2011) Alamdar Hussain et al.   FEBS Journal

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease

(2010) R. A. Marsh et al.   BLOOD

X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease

(2010) C. Booth et al.   BLOOD

IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach

(2010) P. Stepensky et al.   HAEMATOLOGICA

Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells

(2009) K Blomberg et al.   BMC GENOMICS

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

(2009) Julio Gomez-Rodriguez et al.   IMMUNITY

Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk

(2009) Julie A. Readinger et al.   IMMUNOLOGICAL REVIEWS

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION