Vascular and metabolic dysfunction in Alzheimer's disease: a review

Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology

(2017) Stuart Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

Modeling Sporadic Alzheimer's Disease: The Insulin Resistant Brain State Generates Multiple Long-Term Morphobiological Abnormalities Including Hyperphosphorylated Tau Protein and Amyloid-β

(2017) Melita Salkovic-Petrisic et al.   JOURNAL OF ALZHEIMERS DISEASE

Peroxisome Proliferator-Activated Receptor Gamma Enhances the Activity of an Insulin Degrading Enzyme-Like Metalloprotease for Amyloid-β

(2017) Ira Espuny-Camacho et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-Resistant Brain State after Intracerebroventricular Streptozotocin Injection Exacerbates Alzheimer-like Changes in Tg2576 AβPP-Overexpressing Mice

(2017) Konstanze Plaschke et al.   JOURNAL OF ALZHEIMERS DISEASE

Type 2 Diabetes Mellitus, Dyslipidemia, and Alzheimer's Disease

(2017) Cynthia M. Carlsson   JOURNAL OF ALZHEIMERS DISEASE

Insulin resistance and Alzheimer's disease

(2011) Suzanne M. De La Monte   BMB Reports

Oxidant-induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease

(2010) Gary E. Gibson et al.   Annals of the New York Academy of Sciences

Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status

(2010) Jennifer Rodriguez-Rivera et al.   BEHAVIOURAL BRAIN RESEARCH

Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

(2010) Jia Yao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden

(2010) Gil D. Rabinovici et al.   BRAIN

Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke

(2010) Shawn N. Whitehead et al.   BRAIN RESEARCH

Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?

(2010) E. M. V. de Cavanagh et al.   CARDIOVASCULAR RESEARCH

Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice: Role of NADPH Oxidase 4

(2010) J. Li et al.   DIABETES

Increased Food Intake Leads to Obesity and Insulin Resistance in the Tg2576 Alzheimer’s Disease Mouse Model

(2010) Motoyuki Kohjima et al.   ENDOCRINOLOGY

Complex I: Inhibitors, inhibition and neurodegeneration

(2010) A.H.V. Schapira   EXPERIMENTAL NEUROLOGY

Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases

(2010) R. Morales et al.   JOURNAL OF NEUROSCIENCE

Inhibition of hexokinase leads to neuroprotection against excitotoxicity in organotypic hippocampal slice culture

(2010) Kyung Hee Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Alzheimer's disease: Effects of β-amyloid on mitochondria

(2010) Laurent Tillement et al.   MITOCHONDRION

Soluble amyloid-β, effect on cerebral arteriolar regulation and vascular cells

(2010) Hans H Dietrich et al.   Molecular Neurodegeneration

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

An Amyloid-Notch Hypothesis for Alzheimer’s Disease

(2010) Douglas W. Ethell   NEUROSCIENTIST

Aβ and human amylin share a common toxicity pathwayviamitochondrial dysfunction

(2010) Yun-An Lim et al.   PROTEOMICS

Alzheimer's disease: brain expression of a metabolic disorder?

(2010) Sara Merlo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging

(2009) Norbert Schuff et al.   Alzheimers & Dementia

Review: Obesity and Alzheimer’s Disease: A Link Between Body Weight and Cognitive Function in Old Age

(2009) Ebrahim K. Naderali et al.   American Journal of Alzheimers Disease and Other Dementias

Amyloid-Peptide Vaccinations Reduce β-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer’s Transgenic Mice

(2009) Bingqian Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

NADPH Oxidases: Molecular Understanding Finally Reaching the Clinical Level?

(2009) Tomasz J. Guzik et al.   ANTIOXIDANTS & REDOX SIGNALING

NOX Activity Is Increased in Mild Cognitive Impairment

(2009) Annadora J. Bruce-Keller et al.   ANTIOXIDANTS & REDOX SIGNALING

Promising Strategies for the Prevention of Dementia

(2009) Laura E. Middleton et al.   ARCHIVES OF NEUROLOGY

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

(2009) Gary E. Gibson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A metabolic and functional overview of brain aging linked to neurological disorders

(2009) Najma Z. Baquer et al.   BIOGERONTOLOGY

Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

(2009) Tanea T. Reed et al.   BRAIN RESEARCH

Amyloid PET and MRI in Alzheimers Disease and Mild Cognitive Impairment

(2009) E. Dimou et al.   Current Alzheimer Research

Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories

(2009) Gregory J. Brewer   EXPERIMENTAL GERONTOLOGY

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

(2009) P. Hemachandra Reddy   EXPERIMENTAL NEUROLOGY

Metabolic links between diabetes and Alzheimer’s disease

(2009) Pamela A Maher et al.   Expert Review of Neurotherapeutics

Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation

(2009) Kana Tsukuda et al.   HYPERTENSION

Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer’s disease

(2009) Isidre Ferrer   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment

(2009) Rukhsana Sultana et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

NADPH Oxidase Isoforms and Anti-hypertensive Effects of Atorvastatin Demonstrated in Two Animal Models

(2009) Wenhao Cui et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)

(2009) Jessica B.S. Langbaum et al.   NEUROIMAGE

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

(2009) Marzia Perluigi et al.   Proteomics Clinical Applications

Metabolic reprogramming, caloric restriction and aging

(2009) Rozalyn M. Anderson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Angiotensins in Alzheimer's disease – friend or foe?

(2009) Patrick G. Kehoe et al.   TRENDS IN NEUROSCIENCES

Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

(2009) Roy O Weller et al.   Alzheimers Research & Therapy

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

(2008) D. Boche et al.   BRAIN

Preventing Alzheimer’s Disease

(2008) Mary Sano et al.   CNS DRUGS

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-  Peptide, Partial Restoration via  -Secretase Inhibition

(2008) B. H. Han et al.   JOURNAL OF NEUROSCIENCE

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

(2008) Saravanan S. Karuppagounder et al.   NEUROBIOLOGY OF AGING

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON

New therapeutic targets in the neurovascular pathway in Alzheimer’s disease

(2008) Berislav V. Zlokovic   Neurotherapeutics

Ketone bodies as a therapeutic for Alzheimer’s disease

(2008) Samuel T. Henderson   Neurotherapeutics

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Threats to the Mind: Aging, Amyloid, and Hypertension

(2008) C. Iadecola et al.   STROKE

PPARs in Alzheimer's Disease

(2008) Markus P. Kummer et al.   PPAR Research

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL