Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes

(2020) Hugo Lee et al.   Cell Metabolism

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

(2020) Pia Leete et al.   DIABETOLOGIA

Peptides Derived From Insulin Granule Proteins are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice.

(2020) Marie Eliane Azoury et al.   DIABETES

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

(2020) Roberto Mallone et al.   DIABETOLOGIA

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

(2019) Peter J. Thompson et al.   Cell Metabolism

Current therapeutic landscape in multiple sclerosis

(2019) Bruce A.C. Cree et al.   CURRENT OPINION IN NEUROLOGY

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circulating β cell‐specific CD8 + T cells restricted by high‐risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

(2019) L. Yeo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues

(2019) Irina Kusmartseva et al.   DIABETES

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

(2019) Alice E. Wiedeman et al.   JOURNAL OF CLINICAL INVESTIGATION

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

Pancreas Pathology During the Natural History of Type 1 Diabetes

(2018) Teresa Rodriguez-Calvo et al.   Current Diabetes Reports

Type 1 diabetes induction in humanized mice

(2017) Shulian Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of resident lymphocytes in human pancreatic islets

(2016) M. Radenkovic et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

Genetic risk factors for type 1 diabetes

(2016) Flemming Pociot et al.   LANCET

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Characterization of human organ donors testing positive for type 1 diabetes-associated autoantibodies

(2015) A. Wiberg et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance: development of other autoantibodies and progression to type 1 diabetes

(2015) Polly J. Bingley et al.   DIABETOLOGIA

Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes

(2015) Lars Krogvold et al.   DIABETOLOGIA

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients

(2015) Mark R. Rigby et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase

(2015) Teresa Rodriguez-Calvo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

Population dynamics of islet-infiltrating cells in autoimmune diabetes

(2015) Angela M. Magnuson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

(2014) Teresa Rodriguez-Calvo et al.   DIABETES

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

(2014) Sefina Arif et al.   DIABETES

Low-Dose Otelixizumab Anti-CD3 Monoclonal Antibody DEFEND-1 Study: Results of the Randomized Phase III Study in Recent-Onset Human Type 1 Diabetes

(2014) Ronnie Aronson et al.   DIABETES CARE

What is the role of autoimmunity in type 1 diabetes? A clinical perspective

(2014) Marc Y. Donath et al.   DIABETOLOGIA

Pancreatic Pathology in Type 1 Diabetes Mellitus

(2014) Sarah J. Richardson et al.   ENDOCRINE PATHOLOGY

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells

(2014) A. Schneider et al.   JOURNAL OF IMMUNOLOGY

Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment

(2013) Tihamer Orban et al.   DIABETES CARE

The diagnosis of insulitis in human type 1 diabetes

(2013) M. L. Campbell-Thompson et al.   DIABETOLOGIA

Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data

(2012) C. J. Greenbaum et al.   DIABETES

Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations

(2012) A. M. Valdes et al.   DIABETOLOGIA

Zinc transporter (ZnT)8186–194 is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients

(2012) M. Scotto et al.   DIABETOLOGIA

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

(2012) Wendy W. J. Unger et al.   PLoS One

Antidiabetic Actions of Endogenous and Exogenous GLP-1 in Type 1 Diabetic Patients With and Without Residual  -Cell Function

(2011) U. Kielgast et al.   DIABETES

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

(2011) Stephanie A. McClymont et al.   JOURNAL OF IMMUNOLOGY

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

(2011) Nicole Sherry et al.   LANCET

Insulitis in human type 1 diabetes

(2011) Peter In't Veld   Islets

HLA Class I and Genetic Susceptibility to Type 1 Diabetes: Results From the Type 1 Diabetes Genetics Consortium

(2010) J. A. Noble et al.   DIABETES

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

(2010) B. Keymeulen et al.   DIABETOLOGIA

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

(2009) F. S. Wong et al.   DIABETES

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

(2008) Ania Skowera et al.   JOURNAL OF CLINICAL INVESTIGATION