Circulating β cell‐specific CD8 + T cells restricted by high‐risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

Beta cells in type 1 diabetes: mass and function; sleeping or dead?

(2019) Richard A. Oram et al.   DIABETOLOGIA

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

(2018) Deborah Kronenberg-Versteeg et al.   DIABETES

Accelerated Progression to Type 1 Diabetes in the Presence ofHLA-A*24and-B*18Is Restricted to Multiple Islet Autoantibody–Positive Individuals With DistinctHLA-DQand Autoantibody Risk Profiles

(2018) Else M. Balke et al.   DIABETES CARE

Reference values for peripheral blood lymphocyte subsets of healthy children in China

(2018) Yuan Ding et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

(2018) Lorraine Yeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining Memory CD8 T Cell

(2018) Matthew D. Martin et al.   Frontiers in Immunology

Metabolic reprogramming of human CD8+memory T cells through loss of SIRT1

(2017) Mark Y. Jeng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

(2017) Hossam A. Abdelsamed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

The association of theHLA-A*24:02, B*39:01andB*39:06alleles with type 1 diabetes is restricted to specificHLA-DR/DQhaplotypes in Finns

(2017) M.-L. Mikk et al.   HLA

HLA-A*24Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft

(2016) Simke Demeester et al.   DIABETES CARE

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

(2016) Jenny Aurielle B Babon et al.   NATURE MEDICINE

Proportions of CD4+, CD8+ and B cell subsets are not affected by exposure to HIV or to Cotrimoxazole prophylaxis in Malawian HIV-uninfected but exposed children

(2015) Herbert Longwe et al.   BMC IMMUNOLOGY

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes

(2015) Wong Yu et al.   IMMUNITY

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

(2015) Chihiro Motozono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased Memory B Cells and Increased CD8 Memory T Cells in Blood of Breastfed Children: The Generation R Study

(2015) Michelle A. E. Jansen et al.   PLoS One

Characterization of CD8+ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling

(2015) James M. Billingsley et al.   PLoS Pathogens

HbA1cPredicts Time to Diagnosis of Type 1 Diabetes in Children at Risk

(2014) Olli Helminen et al.   DIABETES

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

(2014) Sefina Arif et al.   DIABETES

Antibody Stabilization of Peptide–MHC Multimers Reveals Functional T Cells Bearing Extremely Low-Affinity TCRs

(2014) Katie Tungatt et al.   JOURNAL OF IMMUNOLOGY

Identification and characterisation of peptide binding motifs of six autoimmune disease-associated human leukocyte antigen-class I molecules includingHLA-B*39:06

(2014) M. Eichmann et al.   TISSUE ANTIGENS

Humoral Responses to Islet Antigen-2 and Zinc Transporter 8 Are Attenuated in Patients Carrying HLA-A*24 Alleles at the Onset of Type 1 Diabetes

(2013) A. E. Long et al.   DIABETES

Autoantibodies against zinc transporter 8 are related to age, metabolic state and HLA DR genotype in children with newly diagnosed type 1 diabetes

(2013) K. M. Salonen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The who's who of T-cell differentiation: Human memory T-cell subsets

(2013) Yolanda D. Mahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The HLA-B∗39 allele increases type 1 diabetes risk conferred by HLA-DRB1∗04:04-DQB1∗03:02 and HLA-DRB1∗08-DQB1∗04 class II haplotypes

(2013) M.-L. Mikk et al.   HUMAN IMMUNOLOGY

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

(2013) Mark R Rigby et al.   Lancet Diabetes & Endocrinology

HLA-A*24 Is an Independent Predictor of 5-Year Progression to Diabetes in Autoantibody-Positive First-Degree Relatives of Type 1 Diabetic Patients

(2012) E. Mbunwe et al.   DIABETES

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

(2012) Robin R. Knight et al.   DIABETES

Circulating Preproinsulin Signal Peptide-Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill  -Cells

(2012) D. Kronenberg et al.   DIABETES

Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk

(2012) V. Parikka et al.   DIABETOLOGIA

Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations

(2012) A. M. Valdes et al.   DIABETOLOGIA

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HLA antigen, allele and haplotype frequencies and their use in virtual panel reactive antigen calculations in the Finnish population

(2012) K. Haimila et al.   TISSUE ANTIGENS

Diabetogenic T lymphocytes in human Type 1 diabetes

(2011) Bart O Roep et al.   CURRENT OPINION IN IMMUNOLOGY

Single Insulin-Specific CD8+ T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes

(2011) S. Luce et al.   DIABETES

Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct

(2011) J. M. M. Howson et al.   DIABETES

The HLA-B*3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes

(2011) E. E. Baschal et al.   DIABETOLOGIA

Effect of HLA Class I and Class II Alleles on Progression From Autoantibody Positivity to Overt Type 1 Diabetes in Children With Risk-Associated Class II Genotypes

(2010) K. Lipponen et al.   DIABETES

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

HLA Class I and Genetic Susceptibility to Type 1 Diabetes: Results From the Type 1 Diabetes Genetics Consortium

(2010) J. A. Noble et al.   DIABETES

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

(2010) A. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A

(2009) J. M. M. Howson et al.   DIABETES OBESITY & METABOLISM

The effect of the MHC locus on autoantibodies in type 1 diabetes

(2009) H-Q Qu et al.   JOURNAL OF MEDICAL GENETICS

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes.

(2008) Anna Mäkinen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families

(2008) M C Eike et al.   GENES AND IMMUNITY

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

(2008) Anna Lissina et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET