Pancreas Pathology During the Natural History of Type 1 Diabetes

Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+T Cells in Patients With Type 1 Diabetes

(2018) Meghan L. Marre et al.   DIABETES

Abnormal islet sphingolipid metabolism in type 1 diabetes

(2018) Laurits J. Holm et al.   DIABETOLOGIA

Decreased α-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository

(2018) Fidéline Bonnet-Serrano et al.   PLoS One

Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans

(2018) Charmaine J. Simeonovic et al.   PLoS One

In silico and ex vivo approaches indicate immune pressure on capsid and non-capsid regions of coxsackie B viruses in the human system

(2018) Rhiannon Kundu et al.   PLoS One

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

(2018) Marcela Brissova et al.   Cell Reports

Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank

(2018) Nicholas J Thomas et al.   Lancet Diabetes & Endocrinology

Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention

(2018) Sarah J Richardson et al.   CURRENT OPINION IN PHARMACOLOGY

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children

(2017) Anita Kondrashova et al.   PEDIATRIC DIABETES

Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes

(2017) Julius O. Nyalwidhe et al.   PLoS One

Biomarkers of β-Cell Stress and Death in Type 1 Diabetes

(2016) Raghavendra G. Mirmira et al.   Current Diabetes Reports

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Thinking Outside the Cell: A Key Role for Hyaluronan in the Pathogenesis of Human Type 1 Diabetes

(2016) Marika Bogdani   DIABETES

Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

(2016) Edward A. Phelps et al.   DIABETES

Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes

(2016) Emily K. Sims et al.   DIABETES CARE

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

Lipids and immunoinflammatory pathways of beta cell destruction

(2016) Yumi Imai et al.   DIABETOLOGIA

Viral infections in type 1 diabetes mellitus — why the β cells?

(2016) Anne Op de Beeck et al.   Nature Reviews Endocrinology

Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy

(2016) Sonmoon Mohapatra et al.   PANCREAS

Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization

(2016) Hedwich F. Kuipers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

(2016) Flora Brozzi et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Use of the Electronic Medical Record to Assess Pancreas Size in Type 1 Diabetes

(2016) John Virostko et al.   PLoS One

Characterization of human organ donors testing positive for type 1 diabetes-associated autoantibodies

(2015) A. Wiberg et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Distinct Roles of β-Cell Mass and Function During Type 1 Diabetes Onset and Remission

(2015) Helena Chmelova et al.   DIABETES

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro

(2015) Lars Krogvold et al.   DIABETES

Coxsackievirus B5 Infection Induces Dysregulation of microRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets

(2015) Ki Wook Kim et al.   DIABETES

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

The influence of type 1 diabetes on pancreatic weight

(2015) Martha L. Campbell-Thompson et al.   DIABETOLOGIA

Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes

(2015) Lars Krogvold et al.   DIABETOLOGIA

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study

(2015) Jeffrey P. Krischer et al.   DIABETOLOGIA

Expression Pattern of 12-Lipoxygenase in Human Islets With Type 1 Diabetes and Type 2 Diabetes

(2015) Wojciech J. Grzesik et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

(2015) Nadine Nagy et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase

(2015) Teresa Rodriguez-Calvo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes

(2015) Tanya C. Burch et al.   PLoS One

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

(2015) Laura Marroqui et al.   eLife

Extracellular Matrix Components in the Pathogenesis of Type 1 Diabetes

(2014) Marika Bogdani et al.   Current Diabetes Reports

Viral Infection of Engrafted Human Islets Leads to Diabetes

(2014) Glen R. Gallagher et al.   DIABETES

Hyaluronan and Hyaluronan-Binding Proteins Accumulate in Both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate With Inflammatory Cells in Insulitis

(2014) M. Bogdani et al.   DIABETES

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

(2014) Lars Krogvold et al.   DIABETES

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

(2014) Teresa Rodriguez-Calvo et al.   DIABETES

Most People With Long-Duration Type 1 Diabetes in a Large Population-Based Study Are Insulin Microsecretors

(2014) Richard A. Oram et al.   DIABETES CARE

Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora’s box

(2014) Mark A. Atkinson   DIABETOLOGIA

Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study

(2014) Lars Krogvold et al.   DIABETOLOGIA

Islet inflammation in human type 1 diabetes mellitus

(2014) Noel G. Morgan et al.   IUBMB LIFE

Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology

(2014) Anja Marciniak et al.   Nature Protocols

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

(2014) Noel G. Morgan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Novel Diabetes Autoantibodies and Prediction of Type 1 Diabetes

(2013) Janet M. Wenzlau et al.   Current Diabetes Reports

Acceleration of the Loss of the First-Phase Insulin Response During the Progression to Type 1 Diabetes in Diabetes Prevention Trial-Type 1 Participants

(2013) J. M. Sosenko et al.   DIABETES

Characterization of residualβcell function in long-standing type 1 diabetes

(2013) Jennifer L. Sherr et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells

(2013) Richard A. Oram et al.   DIABETOLOGIA

The diagnosis of insulitis in human type 1 diabetes

(2013) M. L. Campbell-Thompson et al.   DIABETOLOGIA

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

(2013) Anette G. Ziegler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings

(2013) Alberto Pugliese et al.   PEDIATRIC DIABETES

The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human

(2012) E. Korpos et al.   DIABETES

Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data

(2012) C. J. Greenbaum et al.   DIABETES

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Persistence of Prolonged C-peptide Production in Type 1 Diabetes as Measured With an Ultrasensitive C-peptide Assay

(2012) L. Wang et al.   DIABETES CARE

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

(2012) S. J. Richardson et al.   DIABETOLOGIA

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

(2012) I. Marhfour et al.   DIABETOLOGIA

Pancreas Organ Weight in Individuals With Disease-Associated Autoantibodies at Risk for Type 1 Diabetes

(2012) Martha Campbell-Thompson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-Corrected Beta Cell Mass Following Onset of Type 1 Diabetes Mellitus Correlates with Plasma C-Peptide in Humans

(2011) David J. Klinke   PLoS One

Insulitis in human type 1 diabetes

(2011) Peter In't Veld   Islets

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Epidemiology of Type 1 Diabetes

(2010) David M. Maahs et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Preservation of  -Cell Function in Autoantibody-Positive Youth With Diabetes

(2009) C. J. Greenbaum et al.   DIABETES CARE

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Extent of Beta Cell Destruction Is Important but Insufficient to Predict the Onset of Type 1 Diabetes Mellitus

(2008) David J. Klinke   PLoS One