The making of insulin in health and disease

Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 But Not PC2

(2020) Adam Ramzy et al.   DIABETES

Transcription factors that shape the mammalian pancreas

(2020) Rachel E. Jennings et al.   DIABETOLOGIA

β-cell autophagy: Mechanism and role in β-cell dysfunction

(2019) Yong-ho Lee et al.   Molecular Metabolism

Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

(2019) Johan Verhagen et al.   DIABETOLOGIA

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

(2019) Om Prakash Dwivedi et al.   NATURE GENETICS

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D

(2019) Emily K. Sims et al.   Translational Research

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones

(2018) Carrie R. Sowers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells

(2018) Yuichi Tsuchiya et al.   JOURNAL OF CELL BIOLOGY

Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells

(2018) Jalal Taneera et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

(2018) Seyed Mojtaba Ghiasi et al.   DIABETES

Islet prohormone processing in health and disease

(2018) Yi-Chun Chen et al.   DIABETES OBESITY & METABOLISM

Biosynthesis, structure, and folding of the insulin precursor protein

(2018) Ming Liu et al.   DIABETES OBESITY & METABOLISM

A thing of beauty: Structure and function of insulin's “aromatic triplet”

(2018) Michael A. Weiss et al.   DIABETES OBESITY & METABOLISM

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

(2018) Emily K. Sims et al.   DIABETES CARE

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

(2018) Diego Balboa et al.   eLife

Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

(2018) Yael Riahi et al.   eLife

mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress

(2017) Gia Cac Chau et al.   JOURNAL OF CELL BIOLOGY

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags

(2017) Andreas Müller et al.   Scientific Reports

The dynamic plasticity of insulin production in β-cells

(2017) Brandon B. Boland et al.   Molecular Metabolism

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

(2017) Miriam Cnop et al.   Molecular Metabolism

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum

(2016) Leena Haataja et al.   DIABETES

Cerebral cortex: a target and source of insulin?

(2016) Éva A. Csajbók et al.   DIABETOLOGIA

Insulin secretory granules control autophagy in pancreatic   cells

(2015) A. Goginashvili et al.   SCIENCE

SLC30A8 mutations in type 2 diabetes

(2014) Guy A. Rutter et al.   DIABETOLOGIA

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia

(2014) Jalal Taneera et al.   HUMAN MOLECULAR GENETICS

Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes

(2014) Huan Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells

(2014) Klaus-Peter Knoch et al.   Molecular Metabolism

Age-Dependent Labeling and Imaging of Insulin Secretory Granules

(2013) A. Ivanova et al.   DIABETES

Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets

(2013) C. Krautz et al.   DIABETOLOGIA

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

(2013) Mariana Igoillo-Esteve et al.   PLoS Genetics

Regulation of β-cell function by RNA-binding proteins

(2013) Maria Grazia Magro et al.   Molecular Metabolism

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

RNA-Binding Protein HuD Controls Insulin Translation

(2012) Eun Kyung Lee et al.   MOLECULAR CELL

Proinsulin Atypical Maturation and Disposal Induces Extensive Defects in Mouse Ins2+/Akita β-Cells

(2012) Qingxin Yuan et al.   PLoS One

Polymorphism rs11085226 in the Gene Encoding Polypyrimidine Tract-Binding Protein 1 Negatively Affects Glucose-Stimulated Insulin Secretion

(2012) Martin Heni et al.   PLoS One

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism

(2011) Rikard G. Fred et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

High Glucose Suppresses Human Islet Insulin Biosynthesis by Inducing miR-133a Leading to Decreased Polypyrimidine Tract Binding Protein-Expression

(2010) Rikard G. Fred et al.   PLoS One

Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene

(2010) Julie Støy et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The insulin secretory granule as a signaling hub

(2010) Jakob Suckale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Impaired insulin turnover in islets from type 2 diabetic patients

(2010) Florian Ehehalt et al.   Islets

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Rapid Changes of mRNA-binding Protein Levels following Glucose and 3-Isobutyl-1-methylxanthine Stimulation of Insulinoma INS-1 Cells

(2008) Christin Süss et al.   MOLECULAR & CELLULAR PROTEOMICS

The importance of RNA binding proteins in preproinsulin mRNA stability

(2008) R FRED et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Carboxypeptidase E mediates palmitate-induced  -cell ER stress and apoptosis

(2008) K. D. Jeffrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA