IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

Reduced expression of ERp46 under diabetic conditions in β-cells and the effect of liraglutide

(2016) Eugenia Lampropoulou et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Structures and functions of protein disulfide isomerase family members involved in proteostasis in the endoplasmic reticulum

(2015) Masaki Okumura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100

(2015) Shiyu Wang et al.   MOLECULAR BIOLOGY OF THE CELL

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

(2015) Justin R. Hassler et al.   PLOS BIOLOGY

Aberrant islet unfolded protein response in type 2 diabetes

(2014) Feyza Engin et al.   Scientific Reports

Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue

(2013) Hiroshi Kadokura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

(2013) Kazutaka Araki et al.   JOURNAL OF CELL BIOLOGY

Quantitative Analysis of Pancreatic Polypeptide Cell Distribution in the Human Pancreas

(2013) Xiaojun Wang et al.   PLoS One

Negative feedback by IRE1  optimizes mucin production in goblet cells

(2013) A. Tsuru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences

(2013) Angela M. Arensdorf et al.   Frontiers in Genetics

Analysis ofFoxo1-regulated genes usingFoxo1-deficient pancreatic β cells

(2012) Satsuki Miyazaki et al.   GENES TO CELLS

Uncoupling Proteostasis and Developmentin Vitrowith a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK

(2012) Heather P. Harding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

(2011) Ineke Braakman et al.   Annual Review of Biochemistry

ATF2 Interacts with β-Cell-enriched Transcription Factors, MafA, Pdx1, and Beta2, and Activates Insulin Gene Transcription

(2011) Song-iee Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Action of Protein Disulfide Isomerase on Proinsulin Exit from Endoplasmic Reticulum of Pancreatic β-Cells

(2011) Gautam Rajpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

(2011) K. Yanagitani et al.   SCIENCE

Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells

(2010) Yukio Kimata et al.   CURRENT OPINION IN CELL BIOLOGY

Nuclear Hormone Retinoid X Receptor (RXR) Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic  -Cells

(2010) S. Miyazaki et al.   DIABETES

ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

(2010) Ester Zito et al.   JOURNAL OF CELL BIOLOGY

Regulation of basal cellular physiology by the homeostatic unfolded protein response

(2010) D. Thomas Rutkowski et al.   JOURNAL OF CELL BIOLOGY

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Detecting Folding Intermediates of a Protein as It Passes through the Bacterial Translocation Channel

(2009) Hiroshi Kadokura et al.   CELL

Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes

(2009) K. Pechhold et al.   DIABETES

Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals

(2009) K. Mori   JOURNAL OF BIOCHEMISTRY

Proinsulin and the Genetics of Diabetes Mellitus

(2009) Michael A. Weiss   JOURNAL OF BIOLOGICAL CHEMISTRY

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

(2009) T. Iwawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic β-Cells

(2008) Liling Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY