Proinsulin Atypical Maturation and Disposal Induces Extensive Defects in Mouse Ins2+/Akita β-Cells

Proinsulin maturation disorder is a contributor to the defect of subsequent conversion to insulin in β-cells

(2011) Jie Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Control of Precursor Maturation and Disposal Is an Early Regulative Mechanism in the Normal Insulin Production of Pancreatic β-Cells

(2011) Jie Wang et al.   PLoS One

Substrate-Favored Lysosomal and Proteasomal Pathways Participate in the Normal Balance Control of Insulin Precursor Maturation and Disposal in β-Cells

(2011) Xiaoping Zhang et al.   PLoS One

Banting Lecture 2009: An Unfinished Journey: Molecular Pathogenesis to Prevention of Type 1A Diabetes

(2010) G. S. Eisenbarth   DIABETES

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes

(2010) Stephen C. Hanley et al.   ENDOCRINOLOGY

Enhanced Signaling Downstream of Ribonucleic Acid-Activated Protein Kinase-Like Endoplasmic Reticulum Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets

(2010) Laurence Ladrière et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

(2010) Ming Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

(2009) S. E. Kahn et al.   DIABETOLOGIA

Proinsulin and the Genetics of Diabetes Mellitus

(2009) Michael A. Weiss   JOURNAL OF BIOLOGICAL CHEMISTRY

NO sparks off chromatin: Tales of a multifaceted epigenetic regulator

(2009) Barbara Illi et al.   PHARMACOLOGY & THERAPEUTICS

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS