Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

Evidence for gastrointestinal infection of SARS-CoV-2

(2020) Fei Xiao et al.   GASTROENTEROLOGY

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore

(2020) Barnaby Edward Young et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The neuroinvasive potential of SARS‐CoV2 may be at least partially responsible for the respiratory failure of COVID‐19 patients

(2020) Yan‐Chao Li et al.   JOURNAL OF MEDICAL VIROLOGY

Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

COVID-19 and the cardiovascular system

(2020) Ying-Ying Zheng et al.   Nature Reviews Cardiology

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes

(2020) Wei Zhang et al.   Emerging Microbes & Infections

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

NLRP3 Inflammasome—A Key Player in Antiviral Responses

(2020) Chunyuan Zhao et al.   Frontiers in Immunology

Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible?

(2020) Charleen Yeo et al.   Lancet Gastroenterology & Hepatology

Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit

(2020) Duxin Sun   AAPS Journal

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

(2020) Abdul Mannan Baig et al.   ACS Chemical Neuroscience

Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology

(2020) R. Ross Reichard et al.   ACTA NEUROPATHOLOGICA

Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China

(2020) Lei Pan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium

(2020) Haijun Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

Tocilizumab: A Therapeutic Option for the Treatment of Cytokine Storm Syndrome in COVID-19

(2020) Abinit Saha et al.   ARCHIVES OF MEDICAL RESEARCH

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV2 entry and spread in the lymphatic drainage system of the brain

(2020) Mehmet Bostancıklıoğlu   BRAIN BEHAVIOR AND IMMUNITY

SARS-CoV-2: “Three-steps” infection model and CSF diagnostic implication

(2020) Pier Paolo Panciani et al.   BRAIN BEHAVIOR AND IMMUNITY

Current status of potential therapeutic candidates for the COVID-19 crisis

(2020) Jiancheng Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Nervous system involvement after infection with COVID-19 and other coronaviruses

(2020) Yeshun Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Weak Induction of Interferon Expression by SARS-CoV-2 Supports Clinical Trials of Interferon Lambda to Treat Early COVID-19

(2020) Thomas R O’Brien et al.   CLINICAL INFECTIOUS DISEASES

SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

(2020) Soeren Lukassen et al.   EMBO JOURNAL

ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19

(2020) Janice M. Leung et al.   EUROPEAN RESPIRATORY JOURNAL

Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis

(2020) Wei-jie Guan et al.   EUROPEAN RESPIRATORY JOURNAL

Temporal Correlation Between Neurological and Gastrointestinal Symptoms of SARS-CoV-2

(2020) Mehmet Bostancıklıoğlu   INFLAMMATORY BOWEL DISEASES

Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis

(2020) Xiu-wu Pan et al.   INTENSIVE CARE MEDICINE

Findings of lung ultrasonography of novel corona virus pneumonia during the 2019–2020 epidemic

(2020) Qian-Yi Peng et al.   INTENSIVE CARE MEDICINE

The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies

(2020) Adriana Albini et al.   Internal and Emergency Medicine

JAK Inhibition as a New Treatment Strategy for Patients with COVID-19

(2020) Farhad Seif et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

(2020) Chi Zhang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

(2020) Jing Yang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

A first case of meningitis/encephalitis associated with SARS-Coronavirus-2

(2020) Takeshi Moriguchi et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation

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ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma—implications for COVID-19

(2020) Peter Bradding et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Covid‐19 and the digestive system

(2020) Sunny H Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2)

(2020) Alberto Paniz‐Mondolfi et al.   JOURNAL OF MEDICAL VIROLOGY

Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19

(2020) Hao Cheng et al.   JOURNAL OF MEDICAL VIROLOGY

An epidemiological study exploring a possible impact of treatment with ACE inhibitors or angiotensin receptor blockers on ACE2 plasma concentrations

(2020) Philipp S. Wild et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Neurological manifestations of the coronavirus (SARS-CoV-2) pandemic 2019–2020

(2020) Kaiming Liu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2

(2020) Evan A. Farkash et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney disease is associated with in-hospital death of patients with COVID-19

(2020) Yichun Cheng et al.   KIDNEY INTERNATIONAL

Acute kidney injury in patients hospitalized with COVID-19

(2020) Jamie S. Hirsch et al.   KIDNEY INTERNATIONAL

Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

(2020) Hua Su et al.   KIDNEY INTERNATIONAL

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Smell and taste dysfunction in patients with COVID-19

(2020) Michael S Xydakis et al.   LANCET INFECTIOUS DISEASES

Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies

(2020) Sufang Tian et al.   MODERN PATHOLOGY

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

(2020) Yi Xu et al.   NATURE MEDICINE

Kidney involvement in COVID-19 and rationale for extracorporeal therapies

(2020) Claudio Ronco et al.   Nature Reviews Nephrology

Potential neurological impact of coronaviruses: implications for the novel SARS-CoV-2

(2020) Joy D. Iroegbu et al.   NEUROLOGICAL SCIENCES

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Guillain–Barré Syndrome Associated with SARS-CoV-2

(2020) Gianpaolo Toscano et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

(2020) Neeltje van Doremalen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019

(2020) Ashley Barlow et al.   PHARMACOTHERAPY

Sars-Cov-2: Underestimated damage to nervous system

(2020) Lingyan Zhou et al.   Travel Medicine and Infectious Disease

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

(2020) Tao Chen et al.   BMJ-British Medical Journal

Airborne Transmission Route of COVID-19: Why 2 Meters/6 Feet of Inter-Personal Distance Could Not Be Enough

(2020) Leonardo Setti et al.   International Journal of Environmental Research and Public Health

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain

(2020) Zhengqian Li et al.   Frontiers of Medicine

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

(2020) Cynthia Liu et al.   ACS Central Science

HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19

(2020) Francesca Romana Spinelli et al.   Science Immunology

COVID ‐19: A Global Threat to the Nervous System

(2020) Igor J. Koralnik et al.   ANNALS OF NEUROLOGY

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

Don't Overlook Digestive Symptoms in Patients With 2019 Novel Coronavirus Disease (COVID-19)

(2020) Shihua Luo et al.   Clinical Gastroenterology and Hepatology

Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review

(2020) V. Montalvan et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

COVID-19 and acute myocardial injury: the heart of the matter or an innocent bystander?

(2020) Richard Cheng et al.   HEART

Epidemiology and clinical features of COVID-19: A review of current literature

(2020) Juan A. Siordia   JOURNAL OF CLINICAL VIROLOGY

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications

(2020) Sonja Groß et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

p38 MAPK inhibition: A promising therapeutic approach for COVID-19

(2020) Joseph M. Grimes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

First case of drug‐induced liver injury associated with the use of tocilizumab in a patient with COVID‐19

(2020) Damir Muhović et al.   LIVER INTERNATIONAL

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

(2020) Brandi N. Williamson et al.   NATURE

Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19

(2020) Nelly Kanberg et al.   NEUROLOGY

Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?

(2020) Fabio Perrotta et al.   RESPIRATORY MEDICINE

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines

(2019) Masaaki Murakami et al.   IMMUNITY

The Role of Interleukin 6 During Viral Infections

(2019) Lauro Velazquez-Salinas et al.   Frontiers in Microbiology

TLR4/NF-κB signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes

(2019) Yueping Ding et al.   MEDICINE

Factors associated with acute kidney injury in acute respiratory distress syndrome

(2019) Anupol Panitchote et al.   Annals of Intensive Care

Coronaviren als Ursache respiratorischer Infektionen

(2019) V. M. Corman et al.   INTERNIST

Counter-regulatory renin–angiotensin system in cardiovascular disease

(2019) Maria Paz Ocaranza et al.   Nature Reviews Cardiology

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

(2019) Marc Desforges et al.   Viruses-Basel

Baricitinib: A Review in Rheumatoid Arthritis

(2018) Zaina T. Al-Salama et al.   DRUGS

An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication

(2018) Megan H. Orzalli et al.   MOLECULAR CELL

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(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

Neurologic Alterations Due to Respiratory Virus Infections

(2018) Karen Bohmwald et al.   Frontiers in Cellular Neuroscience

Toll-like receptor 4 in acute viral infection: Too much of a good thing

(2018) Judith Olejnik et al.   PLoS Pathogens

Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants

(2017) Kayla M. Peck et al.   JOURNAL OF VIROLOGY

New fronts emerge in the influenza cytokine storm

(2017) Xi-zhi J. Guo et al.   Seminars in Immunopathology

Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era

(2017) Edward M. Behrens et al.   Arthritis & Rheumatology

Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists

(2016) Wei Xu et al.   ACS Chemical Neuroscience

Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury

(2016) Jiping Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung–Kidney Cross-Talk in the Critically Ill Patient

(2016) Faeq Husain-Syed et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases

(2016) Feng Qian et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

Activation of angiotensin-converting enzyme 2 (ACE2) attenuates allergic airway inflammation in rat asthma model

(2016) Vaibhav Shrirang Dhawale et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of angiotensin II type 2 receptor suppresses TNF-α-induced ICAM-1viaNF-κB: possible role of ACE2

(2015) Liping Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Suppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection

(2015) Atsushi Okumura et al.   JOURNAL OF VIROLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

(2015) Allison L. Totura et al.   mBio

Receptor Recognition Mechanisms of Coronaviruses: a Decade of Structural Studies

(2014) Fang Li   JOURNAL OF VIROLOGY

ACE2/Ang-(1–7) signaling and vascular remodeling

(2014) ZhenZhou Zhang et al.   Science China-Life Sciences

Pleiotropic Effects of Interleukin-6 in a “Two-Hit” Murine Model of Acute Respiratory Distress Syndrome

(2014) Julia L. Goldman et al.   Pulmonary Circulation

Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling

(2013) Liang Xiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

(2013) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Role of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases

(2012) Mercedes Rincon et al.   International Journal of Biological Sciences

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(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication

(2012) Yan-Chao Li et al.   JOURNAL OF COMPARATIVE NEUROLOGY

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

The Airway Epithelium: Soldier in the Fight against Respiratory Viruses

(2011) M. Vareille et al.   CLINICAL MICROBIOLOGY REVIEWS

Impaired Nutrient Signaling and Body Weight Control in a Na+Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse

(2011) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-6 Contributes to Inflammation and Remodeling in a Model of Adenosine Mediated Lung Injury

(2011) Mesias Pedroza et al.   PLoS One

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

The role of toll-like receptors in acute and chronic lung inflammation

(2010) Erin I Lafferty et al.   Journal of Inflammation-London

Niacin

(2010) William J. Darby et al.   NUTRITION REVIEWS

Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection

(2010) Tomoki Yoshikawa et al.   PLoS One

Roles of NF-κB in health and disease: mechanisms and therapeutic potential

(2009) Ee Tsin Wong et al.   CLINICAL SCIENCE

Soluble Angiotensin-Converting Enzyme 2 in Human Heart Failure: Relation With Myocardial Function and Clinical Outcomes

(2009) Slava Epelman et al.   JOURNAL OF CARDIAC FAILURE

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

The effects of IL-6 on CD4 T cell responses

(2008) Oliver Dienz et al.   CLINICAL IMMUNOLOGY

Tissue-Specific Amino Acid Transporter Partners ACE2 and Collectrin Differentially Interact With Hartnup Mutations

(2008) Simone M.R. Camargo et al.   GASTROENTEROLOGY

IL-6/IL-6R Axis Plays a Critical Role in Acute Kidney Injury

(2008) Y. Nechemia-Arbely et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

(2008) J. Netland et al.   JOURNAL OF VIROLOGY

Mechanisms of Severe Acute Respiratory Syndrome Pathogenesis and Innate Immunomodulation

(2008) M. Frieman et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Increased activation of p38 MAPK in COPD

(2007) T. Renda et al.   EUROPEAN RESPIRATORY JOURNAL

The role of TLR activation in inflammation

(2007) I Sabroe et al.   JOURNAL OF PATHOLOGY