New fronts emerge in the influenza cytokine storm

Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus

(2017) Amali E. Samarasinghe et al.   JOURNAL OF IMMUNOLOGY

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

Interleukin 33 is a guardian of barriers and a local alarmin

(2016) Nikolas T Martin et al.   NATURE IMMUNOLOGY

IL-33 in T Cell Differentiation, Function, and Immune Homeostasis

(2016) Michael Peine et al.   TRENDS IN IMMUNOLOGY

Trends in U.S. hospitalizations and inpatient deaths from pneumonia and influenza, 1996–2011

(2016) D.H. Chang et al.   VACCINE

Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females

(2016) Olivia J. Hall et al.   PLoS Pathogens

Balancing Immune Protection and Immune Pathology by CD8+ T-Cell Responses to Influenza Infection

(2016) Susu Duan et al.   Frontiers in Immunology

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

(2016) Michelle D. Tate et al.   Scientific Reports

Inflammatory impact of IFN-γ in CD8+ T cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways

(2015) Chilakamarti V. Ramana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair

(2015) Dietmar M.W. Zaiss et al.   IMMUNITY

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

IL-10 inhibits neuraminidase-activated TGF-β and facilitates Th1 phenotype during early phase of infection

(2015) Avijit Dutta et al.   Nature Communications

Mucosal Immune Responses Predict Clinical Outcomes during Influenza Infection Independently of Age and Viral Load

(2014) Christine M. Oshansky et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

The immune profile associated with acute allergic asthma accelerates clearance of influenza virus

(2014) Amali E Samarasinghe et al.   IMMUNOLOGY AND CELL BIOLOGY

CD4+ and CD8+ T Cells Exhibit Differential Requirements for CCR7-Mediated Antigen Transport during Influenza Infection

(2014) A. K. Heer et al.   JOURNAL OF IMMUNOLOGY

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

Human plasmacytoid dendritic cells regulate IFN-α production through activation-induced splicing of IL-18Rα

(2014) Yinxia Chao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Amphiregulin

(2014) Carmen Berasain et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

Anti-IL5 therapy for asthma and beyond

(2014) Manali Mukherjee et al.   World Allergy Organization Journal

Targeting the “Cytokine Storm” for Therapeutic Benefit

(2013) Riccardo V. D'Elia et al.   Clinical and Vaccine Immunology

Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology

(2013) Sarah N. Lauder et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model

(2013) C. M. Rosenberger et al.   JOURNAL OF GENERAL VIROLOGY

Protecting Against Post-influenza Bacterial Pneumonia by Increasing Phagocyte Recruitment and ROS Production

(2013) R. Subramaniam et al.   JOURNAL OF INFECTIOUS DISEASES

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8+ T cell responses to influenza A virus

(2013) Iris K Pang et al.   NATURE IMMUNOLOGY

Group 2 Innate Lymphoid Cell Production of IL-5 Is Regulated by NKT Cells during Influenza Virus Infection

(2013) Stacey Ann Gorski et al.   PLoS Pathogens

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms

(2012) K. Kai McKinstry et al.   JOURNAL OF CLINICAL INVESTIGATION

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung

(2012) O Dienz et al.   Mucosal Immunology

The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

(2012) W. V. Bonilla et al.   SCIENCE

Interleukin-6: from an inflammatory marker to a target for inflammatory diseases

(2012) Mercedes Rincon   TRENDS IN IMMUNOLOGY

Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection

(2012) Michael B.A. Oldstone et al.   VIROLOGY

Infection with Influenza Virus Induces IL-33 in Murine Lungs

(2011) Ronan Le Goffic et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways during Respiratory Virus Challenge

(2010) Jacob E. Kohlmeier et al.   IMMUNITY

Mice Lacking Both TNF and IL‐1 Receptors Exhibit Reduced Lung Inflammation and Delay in Onset of Death following Infection with a Highly Virulent H5N1 Virus

(2010) Lucy A. Perrone et al.   JOURNAL OF INFECTIOUS DISEASES

IFN-γ Treatment at Early Stages of Influenza Virus Infection Protects Mice from Death in a NK Cell-Dependent Manner

(2010) Ido D. Weiss et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

Memory CD4 T Cells Direct Protective Responses to Influenza Virus in the Lungs through Helper-Independent Mechanisms

(2010) J. R. Teijaro et al.   JOURNAL OF VIROLOGY

Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo

(2010) N. A. Jewell et al.   JOURNAL OF VIROLOGY

A Detrimental Effect of Interleukin-10 on Protective Pulmonary Humoral Immunity during Primary Influenza A Virus Infection

(2010) K. Sun et al.   JOURNAL OF VIROLOGY

Interferon-γ: A historical perspective

(2009) Alfons Billiau et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

IL-5- and eosinophil-mediated inflammation: from discovery to therapy

(2009) T. Kouro et al.   INTERNATIONAL IMMUNOLOGY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-10 Deficiency Unleashes an Influenza-Specific Th17 Response and Enhances Survival against High-Dose Challenge

(2009) K. K. McKinstry et al.   JOURNAL OF IMMUNOLOGY

Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge

(2009) H. Hamada et al.   JOURNAL OF IMMUNOLOGY

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

Respiratory Dendritic Cell Subsets Differ in Their Capacity to Support the Induction of Virus-Specific Cytotoxic CD8+ T Cell Responses

(2009) Taeg S. Kim et al.   PLoS One

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection

(2009) J. R. Aldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune responses to influenza A H5N1: friend or foe?

(2009) Joseph Sriyal Malik Peiris et al.   TRENDS IN IMMUNOLOGY

Clearance of influenza virus from the lung depends on migratory langerin+CD11b−but not plasmacytoid dendritic cells

(2008) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IL-33/ST2 pathway: therapeutic target and novel biomarker

(2008) Rahul Kakkar et al.   NATURE REVIEWS DRUG DISCOVERY

Interleukin-6 Is Crucial for Recall of Influenza-Specific Memory CD4+ T Cells

(2008) Maria Paula Longhi et al.   PLoS Pathogens

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens