The acute respiratory distress syndrome

Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury

(2012) Tamás Dolinay et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Plasma angiopoietin-2 in clinical acute lung injury

(2012) Carolyn S. Calfee et al.   CRITICAL CARE MEDICINE

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma

(2012) Jason D. Christie et al.   PLoS One

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema

(2012) R. Lucas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Randomized, Placebo-controlled Clinical Trial of an Aerosolized β2-Agonist for Treatment of Acute Lung Injury

(2011)   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury

(2011) William J Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Active and Passive Cigarette Smoking and Acute Lung Injury after Severe Blunt Trauma

(2011) Carolyn S. Calfee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ANGPT2Genetic Variant Is Associated with Trauma-associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio

(2011) Nuala J. Meyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transfusion-related acute lung injury: incidence and risk factors

(2011) P. Toy et al.   BLOOD

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

The Association Between a Darc Gene Polymorphism and Clinical Outcomes in African American Patients With Acute Lung Injury

(2011) Kirsten Neudoerffer Kangelaris et al.   CHEST

Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury

(2011) Carolyn S. Calfee et al.   CRITICAL CARE MEDICINE

Understanding and applying probabilities at the sickbed

(2011) Samuel Brown et al.   CRITICAL CARE MEDICINE

A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury*

(2011) Robert Paine et al.   CRITICAL CARE MEDICINE

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

(2011) Dörte Schulte et al.   EMBO JOURNAL

Immunomodulatory therapy for severe influenza

(2011) Ilyse Darwish et al.   Expert Review of Anti-Infective Therapy

Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury

(2011) Todd W. Rice   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region

(2011) Raquel Herrero et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice

(2011) Harold A. Chapman et al.   JOURNAL OF CLINICAL INVESTIGATION

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial

(2011) Fang Gao Smith et al.   LANCET

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

Extracorporeal Membrane Oxygenation for ARDS in Adults

(2011) Daniel Brodie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for Human Lung Stem Cells

(2011) Jan Kajstura et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

(2011) Margaret S. Herridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

Sphingosine 1-phosphate in coagulation and inflammation

(2011) Hideru Obinata et al.   Seminars in Immunopathology

Therapies against Virulence Products ofStaphylococcus aureusandPseudomonas aeruginosa

(2011) Jeanine Wiener-Kronish et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice

(2011) A. Goolaerts et al.   THORAX

Neutrophil clearance: when the party is over, clean-up begins

(2011) Donna L. Bratton et al.   TRENDS IN IMMUNOLOGY

Innate Immune Recognition in Infectious and Noninfectious Diseases of the Lung

(2010) Bastian Opitz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis

(2010) Shirley H. J. Mei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Beyond Mortality

(2010) Roger G. Spragg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genetic Variation in theFASGene and Associations with Acute Lung Injury

(2010) Bradford J. Glavan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Eight-Year Trend of Acute Respiratory Distress Syndrome

(2010) Guangxi Li et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early Identification of Patients at Risk of Acute Lung Injury

(2010) Ognjen Gajic et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prolonged Exposure to Sphingosine 1–Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung Injury

(2010) Barry S. Shea et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Therapeutic Potential of Mesenchymal Stem Cells for Severe Acute Lung Injury

(2010) Michael A. Matthay et al.   CHEST

Therapeutic strategies for severe acute lung injury

(2010) Janet V. Diaz et al.   CRITICAL CARE MEDICINE

Allogeneic Human Mesenchymal Stem Cells Restore Epithelial Protein Permeability in Cultured Human Alveolar Type II Cells by Secretion of Angiopoietin-1

(2010) Xiaohui Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Culprits with evolutionary ties

(2010) Carolyn S. Calfee et al.   NATURE

Regeneration and orthotopic transplantation of a bioartificial lung

(2010) Harald C Ott et al.   NATURE MEDICINE

Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome

(2010) Laurent Papazian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury

(2010) B. A. Diep et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung

(2010) J. L. McQualter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvins: Natural agonists for resolution of pulmonary inflammation

(2010) Mohib Uddin et al.   PROGRESS IN LIPID RESEARCH

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

(2010) N. R. London et al.   Science Translational Medicine

Gene association studies in acute lung injury: replication and future direction

(2009) Michelle N. Gong   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Recent advances in genetic predisposition to clinical acute lung injury

(2009) Li Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome

(2009) Julie A. Bastarache et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

(2009) Emma L. Rawlins et al.   Cell Stem Cell

Identification of Early Acute Lung Injury at Initial Evaluation in an Acute Care Setting Prior to the Onset of Respiratory Failure

(2009) Joseph E. Levitt et al.   CHEST

Prognostic and Pathogenetic Value of Combining Clinical and Biochemical Indices in Patients With Acute Lung Injury

(2009) Lorraine B. Ware et al.   CHEST

Recent trends in acute lung injury mortality: 1996–2005*

(2009) Sara E. Erickson et al.   CRITICAL CARE MEDICINE

Management of acute lung injury and acute respiratory distress syndrome in children: A different perspective

(2009) Adrienne G. Randolph   CRITICAL CARE MEDICINE

Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome

(2009) Paolo Taccone et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury

(2009) Franco R. D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial

(2009) Giles J Peek et al.   LANCET

Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

(2009) Christopher A. Jones et al.   NATURE CELL BIOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung

(2009) J. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive species and pulmonary edema

(2009) Karen E Iles et al.   Expert Review of Respiratory Medicine

Randomized Clinical Trial of Activated Protein C for the Treatment of Acute Lung Injury

(2008) Kathleen D. Liu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transepithelial Migration of Neutrophils

(2008) Rachel L. Zemans et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Predictors of hospital mortality in a population-based cohort of patients with acute lung injury*

(2008) Colin R. Cooke et al.   CRITICAL CARE MEDICINE

Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome

(2008) Alain Mercat et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome

(2008) Maureen O. Meade et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE

Mechanical Ventilation Guided by Esophageal Pressure in Acute Lung Injury

(2008) Daniel Talmor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute Lower Respiratory Tract Infection

(2008) Joseph P. Mizgerd   NEW ENGLAND JOURNAL OF MEDICINE

Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury

(2008) C S Calfee et al.   THORAX

Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player

(2008) Dietmar Vestweber et al.   TRENDS IN CELL BIOLOGY