Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Esculin Inhibits the Inflammation of LPS-Induced Acute Lung Injury in Mice Via Regulation of TLR/NF-κB Pathways

(2015) Zhang Tianzhu et al.   INFLAMMATION

Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury

(2015) J. Thangavel et al.   JOURNAL OF CELL SCIENCE

Preferential Recruitment of Neutrophils into the Cerebellum and Brainstem Contributes to the Atypical Experimental Autoimmune Encephalomyelitis Phenotype

(2015) Yudong Liu et al.   JOURNAL OF IMMUNOLOGY

Recombinant human brain natriuretic peptide ameliorates trauma-induced acute lung injury via inhibiting JAK/STAT signaling pathway in rats

(2015) Zhi Song et al.   Journal of Trauma and Acute Care Surgery

LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy

(2015) Mingxin Zuo et al.   Oncotarget

Recombinant human brain natriuretic peptide ameliorates trauma-induced acute lung injury via inhibiting JAK/STAT signaling pathway in rats

(2015) Zhi Song et al.   Journal of Trauma and Acute Care Surgery

The matrikine N- -PGP couples extracellular matrix fragmentation to endothelial permeability

(2015) C. S. Hahn et al.   Science Advances

A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells

(2015) Li Lin et al.   NEOPLASIA

Diverse macrophage populations mediate acute lung inflammation and resolution

(2014) Neil R. Aggarwal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Matrix Metalloproteinases and Protein Tyrosine Kinases

(2014) Yael Aschner et al.   CHEST

Mechanisms of Jak/STAT Signaling in Immunity and Disease

(2014) Alejandro V. Villarino et al.   JOURNAL OF IMMUNOLOGY

Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis

(2014) Etty N. Benveniste et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Role of alveolar macrophages in the regulation of local and systemic inflammation after lung contusion

(2014) Ulrike Niesler et al.   Journal of Trauma and Acute Care Surgery

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Myeloid depletion of SOCS3 enhances LPS-induced acute lung injury through CCAAT/enhancer binding protein δ pathway

(2013) Chunguang Yan et al.   FASEB JOURNAL

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

N-acetylcysteine Administration is Associated with Reduced Activation of NF-kB and Preserves Lung Dendritic Cells Function in a Zymosan-Induced Generalized Inflammation Model

(2012) Hong-Wei Wang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation

(2012) H. Qin et al.   JOURNAL OF IMMUNOLOGY

Anti-Angiogenic Activity of a Small Molecule STAT3 Inhibitor LLL12

(2012) Hemant K. Bid et al.   PLoS One

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

(2012) H. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

(2011) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Resolution of Toll-like receptor 4-mediated acute lung injury is linked to eicosanoids and suppressor of cytokine signaling 3

(2011) Jan N. Hilberath et al.   FASEB JOURNAL

LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling

(2011) Claire J Greenhill et al.   IMMUNOLOGY AND CELL BIOLOGY

Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness

(2011) J Deshane et al.   Mucosal Immunology

Role of CCR2 and IL-8 in acute lung injury: a new mechanism and therapeutic target

(2011) Yao Shen et al.   Expert Review of Respiratory Medicine

NF-κB and STAT3 signaling hubs for lung innate immunity

(2010) Lee J. Quinton et al.   CELL AND TISSUE RESEARCH

Inhibition of STAT3 Signaling Blocks the Anti-apoptotic Activity of IL-6 in Human Liver Cancer Cells

(2010) Yan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation

(2010) Elizabeth F. Redente et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation and Regulation of Systemic Inflammation in ARDS

(2009) G. Umberto Meduri et al.   CHEST

Lung Inflammation, Injury, and Proliferative Response after Repetitive Particulate Hexavalent Chromium Exposure

(2009) Laura M. Beaver et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Different Doses of Lipopolysaccharides Regulate the Lung Inflammation of Asthmatic Mice via TLR4 Pathway in Alveolar Macrophages

(2009) Liang Dong et al.   JOURNAL OF ASTHMA

SOCS1 and SOCS3 in the control of CNS immunity

(2009) Brandi J. Baker et al.   TRENDS IN IMMUNOLOGY

Has Mortality from Acute Respiratory Distress Syndrome Decreased over Time?

(2008) Jason Phua et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of a MAPK p38 inhibitor on lung function and airway inflammation in equine recurrent airway obstruction

(2008) J.-P. LAVOIE et al.   EQUINE VETERINARY JOURNAL

STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury

(2008) Machiko Ikegami et al.   JOURNAL OF APPLIED PHYSIOLOGY

Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium

(2008) Laura M. Beaver et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY