Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies

Perturbation of bulk and selective macroautophagy, abnormal UPR activation and their interplay pave the way to immune dysfunction, cancerogenesis and neurodegeneration in ageing

(2020) Mara Cirone   AGEING RESEARCH REVIEWS

Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells

(2020) Marco Cordani et al.   Biomolecules

Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation

(2020) Alessia Garufi et al.   Biomolecules

The Complexity of Targeting Chemokines to Promote a Tumor Immune Response

(2020) Marianne Strazza et al.   INFLAMMATION

Life, death, and autophagy in cancer: NF-κB turns up everywhere

(2020) Daniela Verzella et al.   Cell Death & Disease

STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway

(2020) Maria Anele Romeo et al.   Frontiers in Oncology

STAT3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation

(2019) Roberta Santarelli et al.   VIROLOGY

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

(2019) Kirsten L. Bryant et al.   NATURE MEDICINE

Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

(2019) Maria Saveria Gilardini Montani et al.   Cancers

Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression

(2019) Gabriella D’Orazi et al.   Cancers

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

Mutant p53 improves cancer cells’ resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6

(2019) Daria Sicari et al.   ONCOGENE

Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization

(2019) Granato et al.   Biomolecules

At the crossway of ER-stress and proinflammatory responses

(2018) Marisa Reverendo et al.   FEBS Journal

STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment

(2018) Federica Laudisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation

(2018) Ya-wei Zhao et al.   Frontiers in Pharmacology

Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

(2018) Xinglong Qu et al.   Frontiers in Immunology

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

(2018) Ramona Schulz-Heddergott et al.   CANCER CELL

Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases

(2018) Elena Y. Kochetkova et al.   Aging-US

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

(2017) Marisa Granato et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

(2017) Marisa Granato et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cancer Inflammation and Cytokines

(2017) Maria Rosaria Galdiero et al.   Cold Spring Harbor Perspectives in Biology

Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

(2017) Homa Rahnamoun et al.   Nature Communications

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

(2017) L. Masuelli et al.   OncoImmunology

Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy

(2017) Marisa Granato et al.   Scientific Reports

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis

(2016) Marco Cordani et al.   CANCER LETTERS

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Depleting stabilized GOF mutant p53 proteins by inhibiting molecular folding chaperones: a new promise in cancer therapy

(2016) Evguenia M Alexandrova et al.   CELL DEATH AND DIFFERENTIATION

Reactivation of mutant p53 by capsaicin, the major constituent of peppers

(2016) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Endoplasmic Reticulum Stress Is a Danger Signal Promoting Innate Inflammatory Responses in Bronchial Epithelial Cells

(2016) Vedrana Mijošek et al.   Journal of Innate Immunity

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells

(2015) Marisa Granato et al.   CANCER LETTERS

p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb

(2015) S. Agarwal et al.   MOLECULAR CANCER RESEARCH

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications

(2015) S Baldari et al.   Cell Death & Disease

ATF6 Mediates a Pro-Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia-Reperfusion Injury

(2014) J. Rao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The role of MAPK signalling pathways in the response to endoplasmic reticulum stress

(2014) Nicola J. Darling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Caught in the cross fire: p53 in inflammation

(2014) Tomer Cooks et al.   CARCINOGENESIS

PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation

(2014) G. P. Meares et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutant p53 Reprograms TNF Signaling in Cancer Cells through Interaction with the Tumor Suppressor DAB2IP

(2014) Giulio Di Minin et al.   MOLECULAR CELL

Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist

(2014) V Ubertini et al.   ONCOGENE

Degradation of mutant p53H175 protein by Zn(II) through autophagy

(2014) A Garufi et al.   Cell Death & Disease

STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells

(2014) Roberta Santarelli et al.   Scientific Reports

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

Dissecting the pathways that destabilize mutant p53: The proteasome or autophagy?

(2013) Sujata Choundhury et al.   CELL CYCLE

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma

(2013) M. Chatterjee et al.   HAEMATOLOGICA

JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells

(2013) Marisa Granato et al.   PLoS One

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells

(2012) Yiu To Yeung et al.   JOURNAL OF NEURO-ONCOLOGY

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

Activation of dendritic cells by tumor cell death

(2012) Mara Cirone et al.   OncoImmunology

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration

(2011) W.Andrew Yeudall et al.   CARCINOGENESIS

Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway

(2011) Sudhanshu Agrawal et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas

(2010) A. P. Bhatt et al.   BLOOD

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy

(2010) Gianluca Bossi et al.   CELL CYCLE

Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function

(2010) Aymone Gurtner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53 Disrupts the Stress MAPK Activation Circuit Induced by ASK1-Dependent Stabilization of Daxx

(2009) T. Kitamura et al.   CANCER RESEARCH

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown

(2008) R. Puca et al.   CANCER RESEARCH

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE