Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies
出版年份 2020 全文链接
标题
Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies
作者
关键词
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出版物
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-10-18
DOI
10.1007/s00018-020-03677-7
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Perturbation of bulk and selective macroautophagy, abnormal UPR activation and their interplay pave the way to immune dysfunction, cancerogenesis and neurodegeneration in ageing
- (2020) Mara Cirone AGEING RESEARCH REVIEWS
- Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells
- (2020) Marco Cordani et al. Biomolecules
- Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation
- (2020) Alessia Garufi et al. Biomolecules
- The Complexity of Targeting Chemokines to Promote a Tumor Immune Response
- (2020) Marianne Strazza et al. INFLAMMATION
- Life, death, and autophagy in cancer: NF-κB turns up everywhere
- (2020) Daniela Verzella et al. Cell Death & Disease
- STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway
- (2020) Maria Anele Romeo et al. Frontiers in Oncology
- STAT3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation
- (2019) Roberta Santarelli et al. VIROLOGY
- Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
- (2019) Kirsten L. Bryant et al. NATURE MEDICINE
- Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells
- (2019) Maria Saveria Gilardini Montani et al. Cancers
- Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression
- (2019) Gabriella D’Orazi et al. Cancers
- Inflammation and Cancer: Triggers, Mechanisms, and Consequences
- (2019) Florian R. Greten et al. IMMUNITY
- Mutant p53 improves cancer cells’ resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6
- (2019) Daria Sicari et al. ONCOGENE
- Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization
- (2019) Granato et al. Biomolecules
- At the crossway of ER-stress and proinflammatory responses
- (2018) Marisa Reverendo et al. FEBS Journal
- STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment
- (2018) Federica Laudisi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mechanism and medical implications of mammalian autophagy
- (2018) Ivan Dikic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation
- (2018) Ya-wei Zhao et al. Frontiers in Pharmacology
- Immunological Approaches Towards Cancer and Inflammation: A Cross Talk
- (2018) Xinglong Qu et al. Frontiers in Immunology
- Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion
- (2018) Ramona Schulz-Heddergott et al. CANCER CELL
- Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases
- (2018) Elena Y. Kochetkova et al. Aging-US
- Mutant p53 as a guardian of the cancer cell
- (2018) Fiamma Mantovani et al. CELL DEATH AND DIFFERENTIATION
- Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
- (2017) Marisa Granato et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways
- (2017) Marisa Granato et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Cancer Inflammation and Cytokines
- (2017) Maria Rosaria Galdiero et al. Cold Spring Harbor Perspectives in Biology
- Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
- (2017) Homa Rahnamoun et al. Nature Communications
- Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice
- (2017) L. Masuelli et al. OncoImmunology
- Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy
- (2017) Marisa Granato et al. Scientific Reports
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis
- (2016) Marco Cordani et al. CANCER LETTERS
- NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
- (2016) Zhenyu Zhong et al. CELL
- Depleting stabilized GOF mutant p53 proteins by inhibiting molecular folding chaperones: a new promise in cancer therapy
- (2016) Evguenia M Alexandrova et al. CELL DEATH AND DIFFERENTIATION
- Reactivation of mutant p53 by capsaicin, the major constituent of peppers
- (2016) Alessia Garufi et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Endoplasmic Reticulum Stress Is a Danger Signal Promoting Innate Inflammatory Responses in Bronchial Epithelial Cells
- (2016) Vedrana Mijošek et al. Journal of Innate Immunity
- Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition
- (2016) Marco Cordani et al. Molecular Oncology
- Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells
- (2015) Marisa Granato et al. CANCER LETTERS
- p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb
- (2015) S. Agarwal et al. MOLECULAR CANCER RESEARCH
- UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
- (2015) Daniela Senft et al. TRENDS IN BIOCHEMICAL SCIENCES
- Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications
- (2015) S Baldari et al. Cell Death & Disease
- ATF6 Mediates a Pro-Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia-Reperfusion Injury
- (2014) J. Rao et al. AMERICAN JOURNAL OF TRANSPLANTATION
- The role of MAPK signalling pathways in the response to endoplasmic reticulum stress
- (2014) Nicola J. Darling et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
- (2014) Patricia A.J. Muller et al. CANCER CELL
- Caught in the cross fire: p53 in inflammation
- (2014) Tomer Cooks et al. CARCINOGENESIS
- PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation
- (2014) G. P. Meares et al. MOLECULAR AND CELLULAR BIOLOGY
- Mutant p53 Reprograms TNF Signaling in Cancer Cells through Interaction with the Tumor Suppressor DAB2IP
- (2014) Giulio Di Minin et al. MOLECULAR CELL
- Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist
- (2014) V Ubertini et al. ONCOGENE
- Degradation of mutant p53H175 protein by Zn(II) through autophagy
- (2014) A Garufi et al. Cell Death & Disease
- STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells
- (2014) Roberta Santarelli et al. Scientific Reports
- Chronic Inflammation and Cytokines in the Tumor Microenvironment
- (2014) Glauben Landskron et al. Journal of Immunology Research
- Dissecting the pathways that destabilize mutant p53: The proteasome or autophagy?
- (2013) Sujata Choundhury et al. CELL CYCLE
- mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
- (2013) Masahiro Morita et al. Cell Metabolism
- Cellular metabolic and autophagic pathways: Traffic control by redox signaling
- (2013) Matthew Dodson et al. FREE RADICAL BIOLOGY AND MEDICINE
- The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma
- (2013) M. Chatterjee et al. HAEMATOLOGICA
- JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells
- (2013) Marisa Granato et al. PLoS One
- Tumour-associated mutant p53 drives the Warburg effect
- (2013) Cen Zhang et al. Nature Communications
- Regulation of Immune Responses by mTOR
- (2012) Jonathan D. Powell et al. Annual Review of Immunology
- p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells
- (2012) Yiu To Yeung et al. JOURNAL OF NEURO-ONCOLOGY
- Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
- (2012) Christian Appenzeller-Herzog et al. TRENDS IN CELL BIOLOGY
- Activation of dendritic cells by tumor cell death
- (2012) Mara Cirone et al. OncoImmunology
- mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
- (2011) P. Gulhati et al. CANCER RESEARCH
- Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration
- (2011) W.Andrew Yeudall et al. CARCINOGENESIS
- Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway
- (2011) Sudhanshu Agrawal et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas
- (2010) A. P. Bhatt et al. BLOOD
- Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy
- (2010) Gianluca Bossi et al. CELL CYCLE
- Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function
- (2010) Aymone Gurtner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutant p53 Disrupts the Stress MAPK Activation Circuit Induced by ASK1-Dependent Stabilization of Daxx
- (2009) T. Kitamura et al. CANCER RESEARCH
- Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response
- (2009) H. Yamazaki et al. JOURNAL OF IMMUNOLOGY
- Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown
- (2008) R. Puca et al. CANCER RESEARCH
- From endoplasmic-reticulum stress to the inflammatory response
- (2008) Kezhong Zhang et al. NATURE
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