Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation

Current Therapeutic Approaches for Targeting Inflammation in Depression and Cardiovascular Disease

(2018) Pedro Zuzarte et al.   CURRENT DRUG METABOLISM

Targeting cytokines in reduction of depressive symptoms: A comprehensive review

(2018) Aisha S. Shariq et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Information processing in the vertebrate habenula

(2018) Stephanie Fore et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Elevation of p11 in lateral habenula mediates depression-like behavior

(2017) J-S Seo et al.   MOLECULAR PSYCHIATRY

The habenula in psychiatric disorders: More than three decades of translational investigation

(2017) Marc Fakhoury   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival

(2017) Hakan Cakmak et al.   Reproductive Sciences

Bifunctional role of pro-inflammatory cytokines after traumatic brain injury

(2016) Peter P. Sordillo et al.   BRAIN INJURY

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

(2016) Ji-chun Zhang et al.   Current Neuropharmacology

Why depression and pain often coexist and mutually reinforce: Role of the lateral habenula

(2016) Jicheng Li et al.   EXPERIMENTAL NEUROLOGY

The Neurobiology of Depression: an Integrated Overview from Biological Theories to Clinical Evidence

(2016) F. Ferrari et al.   MOLECULAR NEUROBIOLOGY

Disrupted habenula function in major depression

(2016) R P Lawson et al.   MOLECULAR PSYCHIATRY

Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression

(2016) Ming-ming Tang et al.   PHYSIOLOGY & BEHAVIOR

The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression

(2016) Yong-Ku Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effects of female gonadal hormones and LPS on depressive-like behavior in rats

(2015) Milos Mitic et al.   Archives of Biological Sciences

The contribution of hypothalamic neuroendocrine, neuroplastic and neuroinflammatory processes to lipopolysaccharide-induced depressive-like behaviour in female and male rats: Involvement of glucocorticoid receptor and C/EBP-β

(2015) Miroslav Adzic et al.   BEHAVIOURAL BRAIN RESEARCH

Lateral habenula as a link between dopaminergic and serotonergic systems contributes to depressive symptoms in Parkinson's disease

(2015) Xiao Feng Luo et al.   BRAIN RESEARCH BULLETIN

BDNF prevents amyloid-dependent impairment of LTP in the entorhinal cortex by attenuating p38 MAPK phosphorylation

(2015) Chiara Criscuolo et al.   NEUROBIOLOGY OF AGING

Integrating the monoamine, neurotrophin and cytokine hypotheses of depression — A central role for the serotonin transporter?

(2015) Jana Haase et al.   PHARMACOLOGY & THERAPEUTICS

New hypothesis and treatment targets of depression: an integrated view of key findings

(2015) Shangli Cai et al.   Neuroscience Bulletin

A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors

(2015) N L Baganz et al.   Translational Psychiatry

Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release

(2014) Emilio Russo et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of the Dorsal Medial Habenula in the Regulation of Voluntary Activity, Motor Function, Hedonic State, and Primary Reinforcement

(2014) Y.-W. A. Hsu et al.   JOURNAL OF NEUROSCIENCE

MAPK signaling correlates with the antidepressant effects of ketamine

(2014) Gislaine Z. Réus et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats

(2013) Yuqin Pan et al.   BEHAVIOURAL BRAIN RESEARCH

CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS

(2013) Andrew H. Miller et al.   DEPRESSION AND ANXIETY

Bipolar disorder diagnosis: challenges and future directions

(2013) Mary L Phillips et al.   LANCET

Windows of vulnerability: Maternal separation, age, and fluoxetine on adolescent depressive-like behavior in rats

(2013) N. Freund et al.   NEUROSCIENCE

Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue

(2011) Jennifer C. Felger et al.   BRAIN BEHAVIOR AND IMMUNITY

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells

(2011) Dexiang Liu et al.   NEUROPHARMACOLOGY

Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline

(2011) Nicoletta Galeotti et al.   NEUROPHARMACOLOGY

Effects of chronic administration of tryptophan with or without concomitant fluoxetine in depression-related and anxiety-like behaviors on adult rat

(2011) Fernanda Hansen et al.   NEUROSCIENCE LETTERS

Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression

(2010) C. Winter et al.   BEHAVIOURAL BRAIN RESEARCH

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats

(2010) Silvia Alboni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Centrally administered lipopolysaccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling

(2010) Zhi-Hua Zhang et al.   JOURNAL OF HYPERTENSION

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE

Interleukin-1 Receptor Activation by Systemic Lipopolysaccharide Induces Behavioral Despair Linked to MAPK Regulation of CNS Serotonin Transporters

(2010) Chong-Bin Zhu et al.   NEUROPSYCHOPHARMACOLOGY

Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression

(2009) Firdaus S. Dhabhar et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia

(2009) K. Ranft et al.   PSYCHOLOGICAL MEDICINE

The effect of chronic fluoxetine on social isolation-induced changes on sucrose consumption, immobility behavior, and on serotonin and dopamine function in hippocampus and ventral striatum

(2008) Juan C. Brenes et al.   BEHAVIOURAL BRAIN RESEARCH

A role for the extracellular signal-regulated kinase signal pathway in depressive-like behavior

(2008) Xiaoli Qi et al.   BEHAVIOURAL BRAIN RESEARCH

Depression, comorbidities and the TNF-α system

(2008) H. Himmerich et al.   EUROPEAN PSYCHIATRY

IL-10 modulates depressive-like behavior

(2008) Ana Raquel Mesquita et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus

(2007) Li-Min Yang et al.   BEHAVIOURAL BRAIN RESEARCH