Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish

K63 ubiquitin chains target NLRP3 inflammasome for autophagic degradation in ox-LDL-stimulated THP-1 macrophages

(2020) Zhenfeng Zhou et al.   Aging-US

Three-Dimensional Imaging Provides Detailed Atherosclerotic Plaque Morphology and Reveals Angiogenesis After Carotid Artery Ligation

(2020) Tobias Becher et al.   CIRCULATION RESEARCH

Opportunities for an atherosclerosis vaccine: From mice to humans

(2020) Payel Roy et al.   VACCINE

Atherosclerosis: Insights into Vascular Pathobiology and Outlook to Novel Treatments

(2020) Marc P. Wolf et al.   Journal of Cardiovascular Translational Research

Toll-Like Receptor 7 Stimulation Promotes the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice

(2020) Alexander O. Krogmann et al.   International Heart Journal

Beyond the CNS: The many peripheral roles of APOE

(2020) Ana B. Martínez-Martínez et al.   NEUROBIOLOGY OF DISEASE

Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets

(2019) Anthony Conway et al.   MOLECULAR THERAPY

Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice

(2019) Lynn Roth et al.   VASCULAR PHARMACOLOGY

Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography

(2019) Yifu Ding et al.   eLife

Neutrophil Extracellular Traps

(2019) Charlotte Thålin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

(2019) Patricia Marchio et al.   Oxidative Medicine and Cellular Longevity

Next-Generation Phenotypic Screening in Early Drug Discovery for Infectious Diseases

(2019) Nathalie Aulner et al.   TRENDS IN PARASITOLOGY

Adaptation of a Mice Doppler Echocardiography Platform to Measure Cardiac Flow Velocities for Embryonic Chicken and Adult Zebrafish

(2019) Fatiha M. Benslimane et al.   Frontiers in Bioengineering and Biotechnology

Endothelial Mineralocorticoid Receptors Contribute to Vascular Inflammation in Atherosclerosis in a Sex-Specific Manner

(2019) M. Elizabeth Moss et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chronological in vivo imaging reveals endothelial inflammation prior to neutrophils accumulation and lipid deposition in HCD-fed zebrafish

(2019) Hui Luo et al.   ATHEROSCLEROSIS

Hyperlipidaemia and cardioprotection: animal models for translational studies

(2019) Ioanna Andreadou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Use of Zebrafish in Drug Discovery Toxicology

(2019) Steven Cassar et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Impact of gadolinium-based contrast agents on the growth of fish cells lines

(2019) M. Parant et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Advanced blood flow assessment in Zebrafish via experimental digital particle image velocimetry and computational fluid dynamics modeling

(2019) Huseyin Enes Salman et al.   MICRON

Somatic Editing ofLdlrWith Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research

(2018) Kelsey E. Jarrett et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial GPR124 Exaggerates the Pathogenesis of Atherosclerosis by Activating Inflammation

(2018) Dong-Mei Gong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

(2018) Matthew M. Mahan et al.   Journal of Nanomaterials

Axitinib attenuates intraplaque angiogenesis, haemorrhages and plaque destabilization in mice

(2018) Bieke Van der Veken et al.   VASCULAR PHARMACOLOGY

Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7

(2018) Rui Lu et al.   EBioMedicine

The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice

(2017) Christine Landlinger et al.   EUROPEAN HEART JOURNAL

Animal models of atherosclerosis

(2017) Besa Emini Veseli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recombinant Human Cytoglobin Prevents Atherosclerosis by Regulating Lipid Metabolism and Oxidative Stress

(2017) Lingling Ou et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish

(2017) Chao Liu et al.   JOURNAL OF LIPID RESEARCH

Mouse models of atherosclerosis: a historical perspective and recent advances

(2017) Yee Ting Lee et al.   Lipids in Health and Disease

Quantitative and qualitative estimation of atherosclerotic plaque burden in vivo at 7T MRI using Gadospin F in comparison to en face preparation evaluated in ApoE KO mice

(2017) Caroline Jung et al.   PLoS One

Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation

(2017) Yury I. Miller et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gold Nanobeacons for Tracking Gene Silencing in Zebrafish

(2017) Milton Cordeiro et al.   Nanomaterials

Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients

(2017) Chao Liu et al.   PLoS One

Nonlinear dynamics of early atherosclerotic plaque formation may determine the efficacy of high density lipoproteins (HDL) in plaque regression

(2017) Alexander D. Chalmers et al.   PLoS One

High-Resolution Magnetic Resonance Imaging of the Regenerating Adult Zebrafish Heart

(2017) Jana Koth et al.   Scientific Reports

A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular ResearchHighlights

(2016) Joseph M. Miano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia

(2016) Manabu Niimi et al.   ATHEROSCLEROSIS

Effects of Shenlian extract on experimental atherosclerosis in ApoE-deficient mice based on ultrasound biomicroscopy

(2016) Yan Guo et al.   BMC Complementary and Alternative Medicine

Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways

(2016) Yajuan Li et al.   Cellular & Molecular Immunology

Passenger Gene Mutations: Unwanted Guests in Genetically Modified Mice

(2016) Cheryl L Ackert-Bicknell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

(2016) Chiranjib Chakraborty et al.   JOURNAL OF NANOBIOTECHNOLOGY

A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model

(2016) Hong Yu Wang et al.   Biology Open

Zebrafish Models for Dyslipidemia and Atherosclerosis Research

(2016) Amnon Schlegel   Frontiers in Endocrinology

Zebrafish small molecule screens: Taking the phenotypic plunge

(2016) Charles H. Williams et al.   Computational and Structural Biotechnology Journal

Tolerization against atherosclerosis using heat shock protein 60

(2015) Cecilia Wick   CELL STRESS & CHAPERONES

CCL2 and CCL5 Are Novel Therapeutic Targets for Estrogen-Dependent Breast Cancer

(2015) S. Svensson et al.   CLINICAL CANCER RESEARCH

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

(2015) C. Liu et al.   Disease Models & Mechanisms

Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp

(2015) Inge R. Fink et al.   MOLECULAR IMMUNOLOGY

Pathophysiology of native coronary, vein graft and in-stent atherosclerosis

(2015) Kazuyuki Yahagi et al.   Nature Reviews Cardiology

Impaired gait pattern as a sensitive tool to assess hypoxic brain damage in a novel mouse model of atherosclerotic plaque rupture

(2015) Lynn Roth et al.   PHYSIOLOGY & BEHAVIOR

Developing predictive assays: The phenotypic screening “rule of 3”

(2015) Fabien Vincent et al.   Science Translational Medicine

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

(2015) Brian J. Bennett et al.   PLoS Genetics

Animal Models in Cardiovascular Research: Hypertension and Atherosclerosis

(2015) Xin-Fang Leong et al.   Biomed Research International

TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice

(2015) Robert Stöhr et al.   Molecular Metabolism

Vulnerable Plaque Detection and Quantification with Gold Particle–Enhanced Computed Tomography in Atherosclerotic Mouse Models

(2015) David De Wilde et al.   Molecular Imaging

Micro-CT Technique Is Well Suited for Documentation of Remodeling Processes in Murine Carotid Arteries

(2015) Christoph Schürmann et al.   PLoS One

Ezetimibe Attenuates Atherosclerosis Associated with Lipid Reduction and Inflammation Inhibition

(2015) Chunmiao Tie et al.   PLoS One

Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease

(2014) Susanne Karbach et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering

(2014) Martin Mæng Bjørklund et al.   CIRCULATION RESEARCH

Comparative studies of Toll-like receptor signalling using zebrafish

(2014) Zakia Kanwal et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The zebrafish as a tool to identify novel therapies for human cardiovascular disease

(2014) A. Asnani et al.   Disease Models & Mechanisms

Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death

(2014) Carole Van der Donckt et al.   EUROPEAN HEART JOURNAL

Methods for targeted mutagenesis in zebrafish using TALENs

(2014) Woong Y. Hwang et al.   METHODS

Vasospasm of Atherosclerotic Coronary Arteries Precipitates Acute Ischemic Myocardial Damage in Myocardial Infarction–Prone Strain of the Watanabe Heritable Hyperlipidemic Rabbits

(2013) Masashi Shiomi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeted cholesterol efflux

(2013) Longhou Fang et al.   CELL CYCLE

A Novel Mouse Model of Atherosclerotic Plaque Instability for Drug Testing and Mechanistic/Therapeutic Discoveries Using Gene and MicroRNA Expression Profiling

(2013) Yung-Chih Chen et al.   CIRCULATION RESEARCH

Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system

(2013) M. van der Vaart et al.   Disease Models & Mechanisms

Ultrasound bio-microscopic image segmentation for evaluation of zebrafish cardiac function

(2013) Xiaowei Zhou et al.   IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

In vitro and in vivo investigations on the effects of low-density lipoprotein concentration polarization and haemodynamics on atherosclerotic localization in rabbit and zebrafish

(2013) X. Xie et al.   Journal of the Royal Society Interface

Accessory molecules for Toll-like receptors in Teleost fish. Identification of TLR4 interactor with leucine-rich repeats (TRIL)

(2013) Danilo Pietretti et al.   MOLECULAR IMMUNOLOGY

Gold Nanoparticles Disrupt Zebrafish Eye Development and Pigmentation

(2013) Ki-Tae Kim et al.   TOXICOLOGICAL SCIENCES

Zebrafish models of dyslipidemia: relevance to atherosclerosis and angiogenesis

(2013) Longhou Fang et al.   Translational Research

Real-time in vivo imaging of size-dependent transport and toxicity of gold nanoparticles in zebrafish embryos using single nanoparticle plasmonic spectroscopy

(2013) L. M. Browning et al.   Interface Focus

Low carbohydrate, high protein diet promotes atherosclerosis in apolipoprotein E/low-density lipoprotein receptor double knockout mice (apoE/LDLR−/−)

(2012) Renata B. Kostogrys et al.   ATHEROSCLEROSIS

A model 450 million years in the making: zebrafish and vertebrate immunity

(2012) S. A. Renshaw et al.   Disease Models & Mechanisms

Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids

(2012) Longhou Fang et al.   FREE RADICAL BIOLOGY AND MEDICINE

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Hooked! Modeling human disease in zebrafish

(2012) Cristina Santoriello et al.   JOURNAL OF CLINICAL INVESTIGATION

Systematic Approaches to Toxicology in the Zebrafish

(2011) Randall T. Peterson et al.   Annual Review of Pharmacology and Toxicology

Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice

(2011) Man C. Wong et al.   ATHEROSCLEROSIS

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Imaging of atherosclerosis: magnetic resonance imaging

(2011) R. Corti et al.   EUROPEAN HEART JOURNAL

In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish

(2011) Longhou Fang et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

(2011) Matthew R. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

(2011) Wu Yin et al.   JOURNAL OF LIPID RESEARCH

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Molecular Cloning and Expression Analysis of P-Selectin from Zebrafish (Danio rerio)

(2010) Guijin Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidized Cholesteryl Esters and Phospholipids in Zebrafish Larvae Fed a High Cholesterol Diet

(2010) Longhou Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of dendritic antigen-presenting cells in the zebrafish

(2010) G. Lugo-Villarino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-Like Receptor-4 and Lipoprotein Accumulation in Macrophages

(2010) Yury I. Miller et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Impaired Fibrillin-1 Function Promotes Features of Plaque Instability in Apolipoprotein E–Deficient Mice

(2009) Jozef L. Van Herck et al.   CIRCULATION

Vascular Lipid Accumulation, Lipoprotein Oxidation, and Macrophage Lipid Uptake in Hypercholesterolemic Zebrafish

(2009) Konstantin Stoletov et al.   CIRCULATION RESEARCH

Organization and promoter analysis of the zebrafish (Danio rerio) chemokine gene (CXC-64) promoter

(2009) Li-Chen Chen et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Heat shock proteins and immune system

(2009) Min-Fu Tsan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cardiovascular Morbidity and Mortality in Rheumatoid Arthritis

(2008) Sherine E. Gabriel   AMERICAN JOURNAL OF MEDICINE

A new mouse mutant for the LDL receptor identified using ENU mutagenesis

(2008) Karen L. Svenson et al.   JOURNAL OF LIPID RESEARCH