Zebrafish Models for Dyslipidemia and Atherosclerosis Research

Do theApoe−/−andLdlr−/–Mice Yield the Same Insight on Atherogenesis?Highlights: Table.

(2016) Godfrey S. Getz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

(2016) Russell D. Berg et al.   CELL

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils

(2016) Todd G. Kirchgessner et al.   Cell Metabolism

Precise Editing of the Zebrafish Genome Made Simple and Efficient

(2016) Kazuyuki Hoshijima et al.   DEVELOPMENTAL CELL

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

(2016) Mark R. Cronan et al.   IMMUNITY

Endoplasmic Reticulum Lipid Flux Influences Enterocyte Nuclear Morphology and Lipid-dependent Transcriptional Responses

(2016) Erin M. Zeituni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXN3 Regulates Hepatic Glucose Utilization

(2016) Santhosh Karanth et al.   Cell Reports

Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish

(2016) Zhenkang Chen et al.   Cell Reports

Metabolic insights from zebrafish genetics, physiology, and chemical biology

(2015) Amnon Schlegel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

(2015) C. Liu et al.   Disease Models & Mechanisms

Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake

(2015) J. P. Otis et al.   Disease Models & Mechanisms

Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease

(2015) Daniel S. Levic et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial

(2015) G Kees Hovingh et al.   LANCET

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Modified High-Density Lipoproteins by Artificial Sweetener, Aspartame, and Saccharin, Showed Loss of Anti-atherosclerotic Activity and Toxicity in Zebrafish

(2014) Jae-Yong Kim et al.   Cardiovascular Toxicology

World Gastroenterology Organisation Global Guidelines

(2014) Douglas R. LaBrecque et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids

(2014) Lourdes Cruz-Garcia et al.   JOURNAL OF LIPID RESEARCH

Disruption ofldlrcauses increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia

(2014) Elizabeth A. O’Hare et al.   JOURNAL OF LIPID RESEARCH

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

(2014) Jotham Suez et al.   NATURE

Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease

(2014) Anders Berg Jørgensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering

(2014) Yukiko Kimura et al.   Scientific Reports

Mouse models of plaque rupture

(2013) Tetsuya Matoba et al.   CURRENT OPINION IN LIPIDOLOGY

A new murine model of stress-induced complex atherosclerotic lesions

(2013) A. H. Najafi et al.   Disease Models & Mechanisms

Biochemistry and pathophysiology of intravascular and intracellular lipolysis

(2013) S. G. Young et al.   GENES & DEVELOPMENT

Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair

(2013) T. O. Auer et al.   GENOME RESEARCH

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Zebrafish models of dyslipidemia: relevance to atherosclerosis and angiogenesis

(2013) Longhou Fang et al.   Translational Research

A Chemical Screening System for Glucocorticoid Stress Hormone Signaling in an Intact Vertebrate

(2012) Benjamin D. Weger et al.   ACS Chemical Biology

Grape skin and loquat leaf extracts and acai puree have potent anti-atherosclerotic and anti-diabetic activity in vitro and in vivo in hypercholesterolemic zebrafish

(2012) JAE-YONG KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hooked! Modeling human disease in zebrafish

(2012) Cristina Santoriello et al.   JOURNAL OF CLINICAL INVESTIGATION

New molecular insights into CETP structure and function: a review

(2012) M. Arthur Charles et al.   JOURNAL OF LIPID RESEARCH

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism

(2012) Philipp Gut et al.   Nature Chemical Biology

ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1

(2012) Inbal Avraham-Davidi et al.   NATURE MEDICINE

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and biophysical insight into cholesteryl ester-transfer protein

(2011) Justin Hall et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Water extracts of cinnamon and clove exhibits potent inhibition of protein glycation and anti-atherosclerotic activity in vitro and in vivo hypolipidemic activity in zebrafish

(2011) Seori Jin et al.   FOOD AND CHEMICAL TOXICOLOGY

Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia

(2011) Jae-Yong Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination With Statins on HDL and LDL Cholesterol

(2011) Stephen J. Nicholls et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish

(2011) Longhou Fang et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

(2011) Wu Yin et al.   JOURNAL OF LIPID RESEARCH

Turmeric and Laurel Aqueous Extracts Exhibit In Vitro Anti-Atherosclerotic Activity and In Vivo Hypolipidemic Effects in a Zebrafish Model

(2011) Seori Jin et al.   JOURNAL OF MEDICINAL FOOD

National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3·0 million participants

(2011) Farshad Farzadfar et al.   LANCET

National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5·4 million participants

(2011) Goodarz Danaei et al.   LANCET

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Growth and Body Composition of Zebrafish (Danio rerio) Larvae Fed a Compound Feed from First Feeding Onward: Toward Implications on Nutrient Requirements

(2011) Sadasivam Kaushik et al.   Zebrafish

Oxidized Cholesteryl Esters and Phospholipids in Zebrafish Larvae Fed a High Cholesterol Diet

(2010) Longhou Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular Lipid Accumulation, Lipoprotein Oxidation, and Macrophage Lipid Uptake in Hypercholesterolemic Zebrafish

(2009) Konstantin Stoletov et al.   CIRCULATION RESEARCH

The evolution of plasma cholesterol: Direct utility or a “spandrel” of hepatic lipid metabolism?

(2008) Patrick J. Babin et al.   PROGRESS IN LIPID RESEARCH