Regulation of Host Immune Responses against Influenza A Virus Infection by Mitogen-Activated Protein Kinases (MAPKs)

Two waves of pro-inflammatory factors are released during the influenza A virus (IAV)-driven pulmonary immunopathogenesis

(2020) Junsong Zhang et al.   PLoS Pathogens

Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

(2020) Xin Wang et al.   Lancet Global Health

Berberine Hampers Influenza A Replication through Inhibition of MAPK/ERK Pathway

(2020) Paweł Botwina et al.   Viruses-Basel

On the Alert for Cytokine Storm: Immunopathology in COVID ‐19

(2020) Lauren A. Henderson et al.   Arthritis & Rheumatology

COVID-19, SARS and MERS: are they closely related?

(2020) N. Petrosillo et al.   CLINICAL MICROBIOLOGY AND INFECTION

Immune Responses to Avian Influenza Viruses

(2019) Marios Koutsakos et al.   JOURNAL OF IMMUNOLOGY

Influenza Virus Infections and Cellular Kinases

(2019) Robert Meineke et al.   Viruses-Basel

DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response

(2019) Ming Zhong et al.   Virology Journal

Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses

(2019) Maria Auladell et al.   Frontiers in Immunology

Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation

(2019) K. Kai McKinstry et al.   PLoS Pathogens

Influenza virus-specific CD4+ and CD8+ T cell-mediated immunity induced by infection and vaccination

(2019) Janina M. Jansen et al.   JOURNAL OF CLINICAL VIROLOGY

TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection

(2019) Marine de Marcken et al.   Science Signaling

An update on the NLRP3 inflammasome and influenza: the road to redemption or perdition?

(2018) Tate Michelle D et al.   CURRENT OPINION IN IMMUNOLOGY

CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential

(2018) Andrea J. Sant et al.   IMMUNOLOGICAL REVIEWS

Oxymatrine Inhibits Influenza A Virus Replication and Inflammation via TLR4, p38 MAPK and NF-κB Pathways

(2018) Jian-Ping Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Influenza Virus: Dealing with a Drifting and Shifting Pathogen

(2018) Hyunsuh Kim et al.   VIRAL IMMUNOLOGY

Host Immune Response to Influenza A Virus Infection

(2018) Xiaoyong Chen et al.   Frontiers in Immunology

Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose

(2018) Lindsey E. Carlin et al.   Frontiers in Immunology

Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like Receptor 7

(2018) Sabine Stegemann-Koniszewski et al.   Frontiers in Immunology

The CD8 T Cell Response to Respiratory Virus Infections

(2018) Megan E. Schmidt et al.   Frontiers in Immunology

Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement

(2018) Dan Dou et al.   Frontiers in Immunology

Nuclear-resident RIG-I senses viral replication inducing antiviral immunity

(2018) GuanQun Liu et al.   Nature Communications

Alveolar Macrophages in the Resolution of Inflammation, Tissue Repair, and Tolerance to Infection

(2018) Benoit Allard et al.   Frontiers in Immunology

RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo

(2018) Wenxin Wu et al.   MEDIATORS OF INFLAMMATION

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection

(2017) Christoph Coch et al.   MOLECULAR THERAPY

The evolution of seasonal influenza viruses

(2017) Velislava N. Petrova et al.   NATURE REVIEWS MICROBIOLOGY

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology

(2017) Chloe J. Pyle et al.   PLoS Pathogens

Vemurafenib Limits Influenza A Virus Propagation by Targeting Multiple Signaling Pathways

(2017) Magdalena Holzberg et al.   Frontiers in Microbiology

Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3

(2017) Chenyang Yi et al.   Frontiers in Immunology

A Role for Neutrophils in Viral Respiratory Disease

(2017) Jeremy V. Camp et al.   Frontiers in Immunology

Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection

(2017) Carolin Klemm et al.   Scientific Reports

Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection

(2016) Bastian Hatesuer et al.   Journal of Innate Immunity

A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+T Cell Responses

(2016) Sergio M. Quiñones-Parra et al.   JOURNAL OF VIROLOGY

The host immune response in respiratory virus infection: balancing virus clearance and immunopathology

(2016) Amy H. Newton et al.   Seminars in Immunopathology

Human Influenza Virus Infections

(2016) Christin Peteranderl et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Influenza

(2016) Sam Ghebrehewet et al.   BMJ-British Medical Journal

Type I interferons in viral control and immune regulation

(2016) John R Teijaro   Current Opinion in Virology

Influenza

(2016) Sam Ghebrehewet et al.   BMJ-British Medical Journal

Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors

(2016) Azadeh Bahadoran et al.   Frontiers in Microbiology

Regulatory Roles of MAPK Phosphatases in Cancer

(2016) Heng Boon Low et al.   Immune Network

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

(2016) Michelle D. Tate et al.   Scientific Reports

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Influenza virus-induced lung injury: pathogenesis and implications for treatment

(2015) Susanne Herold et al.   EUROPEAN RESPIRATORY JOURNAL

The innate immune function of airway epithelial cells in inflammatory lung disease

(2015) Pieter S. Hiemstra et al.   EUROPEAN RESPIRATORY JOURNAL

H5N1 influenza virulence, pathogenicity and transmissibility: what do we know?

(2015) Gabriele Neumann   Future Virology

Effect of sesamin against cytokine production from influenza type A H1N1-induced peripheral blood mononuclear cells: computational and experimental studies

(2015) Kanda Fanhchaksai et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

(2015) Michelle Goritzka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality

(2015) Ming-Ting Huang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1

(2015) Chuan Xia et al.   JOURNAL OF VIROLOGY

Virus-specific T cells as correlate of (cross-)protective immunity against influenza

(2015) Arwen F. Altenburg et al.   VACCINE

RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cells

(2015) Wenxin Wu et al.   VIROLOGY

Influenza virus activation of the interferon system

(2015) Marian J. Killip et al.   VIRUS RESEARCH

Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus

(2015) Teneema Kuriakose et al.   PLoS Pathogens

Delivery of GM-CSF to Protect against Influenza Pneumonia

(2015) Renuka Subramaniam et al.   PLoS One

Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation

(2014) Jingjing Xie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Induction of Proinflammatory Cytokines in Primary Human Macrophages by Influenza A Virus (H5N1) Is Selectively Regulated by IFN Regulatory Factor 3 and p38 MAPK

(2014) K. P. Y. Hui et al.   JOURNAL OF IMMUNOLOGY

Influenza Virus Reservoirs and Intermediate Hosts: Dogs, Horses, and New Possibilities for Influenza Virus Exposure of Humans

(2014) Colin R. Parrish et al.   JOURNAL OF VIROLOGY

Early Activation of MAP Kinases by Influenza A Virus X-31 in Murine Macrophage Cell Lines

(2014) Georgetta Cannon et al.   PLoS One

Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection

(2014) S. M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection

(2013) Marlène Brandes et al.   CELL

Determinants of virulence of influenza A virus

(2013) E. J. A. Schrauwen et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protects Mice from Lethal H5N1 Infection

(2013) Yvonne Börgeling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4+T helper cells use CD154–CD40 interactions to counteract T reg cell–mediated suppression of CD8+T cell responses to influenza

(2013) André Ballesteros-Tato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody-Dependent Cellular Cytotoxicity Is Associated with Control of Pandemic H1N1 Influenza Virus Infection of Macaques

(2013) S. Jegaskanda et al.   JOURNAL OF VIROLOGY

Influenza virus and cell signaling pathways

(2013) Pratibha Gaur et al.   MEDICAL SCIENCE MONITOR

Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I

(2013) Iris K. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

(2013) Julie L. McAuley et al.   PLoS Pathogens

CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin

(2012) Akihiko Ichikawa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages

(2012) Judith Friesenhagen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TLR7 Recognition Is Dispensable for Influenza Virus A Infection but Important for the Induction of Hemagglutinin-Specific Antibodies in Response to the 2009 Pandemic Split Vaccine in Mice

(2012) V. Jeisy-Scott et al.   JOURNAL OF VIROLOGY

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Innate Immune Response of Human Alveolar Macrophages during Influenza A Infection

(2012) Jieru Wang et al.   PLoS One

MHC Class I-Presented T Cell Epitopes Identified by Immunoproteomics Analysis Are Targets for a Cross Reactive Influenza-Specific T Cell Response

(2012) James S. Testa et al.   PLoS One

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

GM-CSF in the Lung Protects against Lethal Influenza Infection

(2011) Fang-Fang Huang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Airway Epithelium: Soldier in the Fight against Respiratory Viruses

(2011) M. Vareille et al.   CLINICAL MICROBIOLOGY REVIEWS

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

Innate and adaptive immune responses to viral infection and vaccination

(2011) Taiki Aoshi et al.   Current Opinion in Virology

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design

(2010) Takeshi Ichinohe   Expert Review of Vaccines

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-15 Is Critical in the Pathogenesis of Influenza A Virus-Induced Acute Lung Injury

(2010) R. Nakamura et al.   JOURNAL OF VIROLOGY

Memory CD4 T Cells Direct Protective Responses to Influenza Virus in the Lungs through Helper-Independent Mechanisms

(2010) J. R. Teijaro et al.   JOURNAL OF VIROLOGY

Hyperactive immune cells (T cells) may be responsible for acute lung injury in influenza virus infections: A need for early immune-modulators for severe cases

(2010) Kyung-Yil Lee et al.   MEDICAL HYPOTHESES

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

MKP-1 Is Necessary for T Cell Activation and Function

(2009) Yongliang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin and RIG-I/MAVS Signaling Components Translocate to Mitochondria upon Influenza A Virus Infection of Human Primary Macrophages

(2009) T. Ohman et al.   JOURNAL OF IMMUNOLOGY

Essential Impact of NF- B Signaling on the H5N1 Influenza A Virus-Induced Transcriptome

(2009) M. Schmolke et al.   JOURNAL OF IMMUNOLOGY

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Innate immunity to influenza virus: implications for future therapy

(2008) Mitchell R White et al.   Expert Review of Clinical Immunology

Regulation of Mitochondrial Antiviral Signaling Pathways

(2008) Chris B. Moore et al.   IMMUNITY

Analysis of gene expression in human bronchial epithelial cells upon influenza virus infection and regulation by p38 mitogen-activated protein kinase and c-Jun-N-terminal kinase

(2008) Shinichi HAYASHI et al.   RESPIROLOGY