The CD8 T Cell Response to Respiratory Virus Infections

Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection

(2018) Megan E. Schmidt et al.   PLoS Pathogens

Reduced generation of lung tissue–resident memory T cells during infancy

(2017) Kyra D. Zens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunologic Profiling of Human Metapneumovirus for the Development of Targeted Immunotherapy

(2017) Ifigeneia Tzannou et al.   JOURNAL OF INFECTIOUS DISEASES

Recombinant baculovirus-based vaccine expressing M2 protein induces protective CD8+ T-cell immunity against respiratory syncytial virus infection

(2017) Jeong-Yoon Lee et al.   JOURNAL OF MICROBIOLOGY

Airway T cells protect against RSV infection in the absence of antibody

(2017) E Kinnear et al.   Mucosal Immunology

Specific niches for lung-resident memory CD8 + T cells at the site of tissue regeneration enable CD69-independent maintenance

(2016) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple Inhibitory Pathways Contribute to Lung CD8+T Cell Impairment and Protect against Immunopathology during Acute Viral Respiratory Infection

(2016) John J. Erickson et al.   JOURNAL OF IMMUNOLOGY

Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung

(2016) K M Morabito et al.   Mucosal Immunology

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

(2015) Maximillian S. Habibi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study

(2015) Andrew C. Hayward et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epitope specific T-cell responses against influenza A in a healthy population

(2015) Miloje Savic et al.   IMMUNOLOGY

Smad4 Promotes Differentiation of Effector and Circulating Memory CD8 T Cells but Is Dispensable for Tissue-Resident Memory CD8 T Cells

(2015) Yinghong Hu et al.   JOURNAL OF IMMUNOLOGY

Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-γ Production

(2015) Sean R. McMaster et al.   JOURNAL OF IMMUNOLOGY

Lung CD8+T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+T Cells

(2015) Sherry C. Wen et al.   JOURNAL OF VIROLOGY

Immune Surveillance by Rhinovirus-Specific Circulating CD4+ and CD8+ T Lymphocytes

(2015) John W. Steinke et al.   PLoS One

RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection

(2015) Agnieszka Jozwik et al.   Nature Communications

Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells

(2015) Zhongfang Wang et al.   Nature Communications

Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness

(2014) K. T. Zlateva et al.   EUROPEAN RESPIRATORY JOURNAL

CD8 T cells utilize TRAIL to control influenza virus infection.

(2014) E. L. Brincks et al.   JOURNAL OF IMMUNOLOGY

Dynamics of Human Respiratory Virus-Specific CD8+ T Cell Responses in Blood and Airways during Episodes of Common Cold

(2014) J. Heidema et al.   JOURNAL OF IMMUNOLOGY

Programmed Death-1 Impairs Secondary Effector Lung CD8+T Cells during Respiratory Virus Reinfection

(2014) John J. Erickson et al.   JOURNAL OF IMMUNOLOGY

Animal Model of Respiratory Syncytial Virus: CD8+ T Cells Cause a Cytokine Storm That Is Chemically Tractable by Sphingosine-1-Phosphate 1 Receptor Agonist Therapy

(2014) K. B. Walsh et al.   JOURNAL OF VIROLOGY

Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

(2014) R. Channappanavar et al.   JOURNAL OF VIROLOGY

The Pulmonary Localization of Virus-Specific T Lymphocytes Is Governed by the Tissue Tropism of Infection

(2014) C. J. Knudson et al.   JOURNAL OF VIROLOGY

Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection

(2014) S Yao et al.   Mucosal Immunology

Differential Roles of Lung Dendritic Cell Subsets Against Respiratory Virus Infection

(2014) Tae Hoon Kim et al.   Immune Network

CD8+Treg cells suppress CD8+T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection

(2013) Qiang Zou et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The who's who of T-cell differentiation: Human memory T-cell subsets

(2013) Yolanda D. Mahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus

(2013) Bram Slütter et al.   IMMUNITY

Antigen-Specific Memory Regulatory CD4+Foxp3+ T Cells Control Memory Responses to Influenza Virus Infection

(2013) E. L. Brincks et al.   JOURNAL OF IMMUNOLOGY

Lung-resident memory CD8 T cells (TRM ) are indispensable for optimal cross-protection against pulmonary virus infection

(2013) Tao Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Local Blockade of Epithelial PDL-1 in the Airways Enhances T Cell Function and Viral Clearance during Influenza Virus Infection

(2013) Beth McNally et al.   JOURNAL OF VIROLOGY

Lung niches for the generation and maintenance of tissue-resident memory T cells

(2013) D L Turner et al.   Mucosal Immunology

Enhanced survival of lung tissue-resident memory CD8+ T cells during infection with influenza virus due to selective expression of IFITM3

(2013) Linda M Wakim et al.   NATURE IMMUNOLOGY

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection

(2013) Asuncion Mejias et al.   PLOS MEDICINE

Viral acute lower respiratory infections impair CD8+ T cells through PD-1

(2012) John J. Erickson et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection

(2012) H. Hamada et al.   JOURNAL OF IMMUNOLOGY

Vaccine-Elicited CD8+ T Cells Protect against Respiratory Syncytial Virus Strain A2-Line19F-Induced Pathogenesis in BALB/c Mice

(2012) S. Lee et al.   JOURNAL OF VIROLOGY

Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study

(2012) Fatimah S Dawood et al.   LANCET INFECTIOUS DISEASES

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-10 Regulates Viral Lung Immunopathology during Acute Respiratory Syncytial Virus Infection in Mice

(2012) Jens Loebbermann et al.   PLoS One

Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice

(2012) Mary J.G. van Helden et al.   VACCINE

Central role of dendritic cells in shaping the adaptive immune response during respiratory syncytial virus infection

(2011) Daniel S McDermott et al.   Future Virology

Inflammatory chemokine receptors regulate CD8+T cell contraction and memory generation following infection

(2011) Jacob E. Kohlmeier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple CD4+ T Cell Subsets Produce Immunomodulatory IL-10 During Respiratory Syncytial Virus Infection

(2011) K. A. Weiss et al.   JOURNAL OF IMMUNOLOGY

Influenza A Virus Infection Results in a Robust, Antigen-Responsive, and Widely Disseminated Foxp3+ Regulatory T Cell Response

(2011) R. J. Betts et al.   JOURNAL OF VIROLOGY

Environmental and Antigen Receptor-Derived Signals Support Sustained Surveillance of the Lungs by Pathogen-Specific Cytotoxic T Lymphocytes

(2011) Y.-T. Lee et al.   JOURNAL OF VIROLOGY

Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis

(2011) Harish Nair et al.   LANCET

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses

(2011) S. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine

(2011) Wilbur H. Chen et al.   VACCINE

Cross-Reactive T Cells Are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus in Nonhuman Primates

(2011) Jason T. Weinfurter et al.   PLoS Pathogens

CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells

(2010) W. H. ALWAN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways during Respiratory Virus Challenge

(2010) Jacob E. Kohlmeier et al.   IMMUNITY

Foxp3+ CD4 Regulatory T Cells Limit Pulmonary Immunopathology by Modulating the CD8 T Cell Response during Respiratory Syncytial Virus Infection

(2010) R. B. Fulton et al.   JOURNAL OF IMMUNOLOGY

RSV-Induced Bronchial Epithelial Cell PD-L1 Expression Inhibits CD8+ T Cell Nonspecific Antiviral Activity

(2010) Aurica G. Telcian et al.   JOURNAL OF INFECTIOUS DISEASES

Epitope-Specific Regulatory CD4 T Cells Reduce Virus-Induced Illness while Preserving CD8 T-Cell Effector Function at the Site of Infection

(2010) Jie Liu et al.   JOURNAL OF VIROLOGY

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

The Chemokine MIP1α/CCL3 Determines Pathology in Primary RSV Infection by Regulating the Balance of T Cell Populations in the Murine Lung

(2010) John S. Tregoning et al.   PLoS One

Estimates of US influenza-associated deaths made using four different methods

(2009) William W. Thompson et al.   Influenza and Other Respiratory Viruses

Regulatory T Cells Promote Early Influx of CD8+ T Cells in the Lungs of Respiratory Syncytial Virus-Infected Mice and Diminish Immunodominance Disparities

(2009) T. J. Ruckwardt et al.   JOURNAL OF VIROLOGY

Incubation periods of acute respiratory viral infections: a systematic review

(2009) Justin Lessler et al.   LANCET INFECTIOUS DISEASES

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

In situ imaging reveals different responses by naïve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection

(2008) Kamal M. Khanna et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Chemokine Receptor CCR5 Plays a Key Role in the Early Memory CD8+ T Cell Response to Respiratory Virus Infections

(2008) Jacob E. Kohlmeier et al.   IMMUNITY

Major Histocompatibility Complex Class I Cytotoxic T Lymphocyte Immunity to Human Metapneumovirus (hMPV) in Individuals with Previous hMPV Infection and Respiratory Disease

(2008) Karen A. Herd et al.   JOURNAL OF INFECTIOUS DISEASES

Role of T Cells in Virus Control and Disease after Infection with Pneumonia Virus of Mice

(2008) S. Frey et al.   JOURNAL OF VIROLOGY

Regulation of Cytokine Production by Virus-Specific CD8 T Cells in the Lungs

(2008) R. B. Fulton et al.   JOURNAL OF VIROLOGY

T Lymphocytes Contribute to Antiviral Immunity and Pathogenesis in Experimental Human Metapneumovirus Infection

(2008) D. Kolli et al.   JOURNAL OF VIROLOGY

Respiratory Syncytial Virus and Influenza Virus Infections

(2008) Timothy P. Welliver et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Activation of the Granzyme Pathway in Children With Severe Respiratory Syncytial Virus Infection

(2008) Reinout A Bem et al.   PEDIATRIC RESEARCH

Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection

(2008) Joshua M DiNapoli et al.   Virology Journal