A Role for Neutrophils in Viral Respiratory Disease

Understanding the molecular mechanisms of NETs and their role in antiviral innate immunity

(2017) Juan Manuel Agraz-Cibrian et al.   VIRUS RESEARCH

Granulopoiesis and granules of human neutrophils

(2016) Jack B. Cowland et al.   IMMUNOLOGICAL REVIEWS

The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition

(2016) Aurore Vidy et al.   PLoS One

Neutrophils in viral infections: Current concepts and caveats

(2015) I. E. Galani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lower Respiratory Tract Infection of the Ferret by 2009 H1N1 Pandemic Influenza A Virus Triggers Biphasic, Systemic, and Local Recruitment of Neutrophils

(2015) Jeremy V. Camp et al.   JOURNAL OF VIROLOGY

Immunophenotype Expressions and Cytokine Profiles of Influenza A H1N1 Virus Infection in Pediatric Patients in 2009

(2014) Shih-Min Wang et al.   DISEASE MARKERS

Role of receptor binding specificity in influenza A virus transmission and pathogenesis

(2014) M. de Graaf et al.   EMBO JOURNAL

The Pathology and Pathogenesis of Experimental Severe Acute Respiratory Syndrome and Influenza in Animal Models

(2014) J.M.A. van den Brand et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection

(2014) Angus T. Stock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps

(2014) Martin J. Raftery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice

(2014) Y. H. C. Leung et al.   JOURNAL OF GENERAL VIROLOGY

Activation of an Immunoregulatory and Antiviral Gene Expression Program in Poly(I:C)-Transfected Human Neutrophils

(2014) N. Tamassia et al.   JOURNAL OF IMMUNOLOGY

Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis

(2014) Raymond J Pickles et al.   JOURNAL OF PATHOLOGY

Pathogenesis of Middle East respiratory syndrome coronavirus

(2014) Judith MA van den Brand et al.   JOURNAL OF PATHOLOGY

Animal Model of Respiratory Syncytial Virus: CD8+ T Cells Cause a Cytokine Storm That Is Chemically Tractable by Sphingosine-1-Phosphate 1 Receptor Agonist Therapy

(2014) K. B. Walsh et al.   JOURNAL OF VIROLOGY

The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection

(2014) Christopher Schliehe et al.   NATURE IMMUNOLOGY

NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein

(2014) J. Jaworska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF

(2014) J. P. Kolb et al.   Science Signaling

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway

(2014) Su-Yu Tsai et al.   PLoS Pathogens

Does Type I Interferon Limit Protective Neutrophil Responses during Pulmonary Francisella Tularensis Infection?

(2014) Yoichi Furuya et al.   Frontiers in Immunology

Accumulation of CD11b+Gr-1+ cells in the lung, blood and bone marrow of mice infected with highly pathogenic H5N1 and H1N1 influenza viruses

(2013) James P. Long et al.   ARCHIVES OF VIROLOGY

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Human infection with avian influenza A(H7N9) virus re-emerges in China in winter 2013

(2013) E Chen et al.   Eurosurveillance

Inducible Nitric Oxide Contributes to Viral Pathogenesis Following Highly Pathogenic Influenza Virus Infection in Mice

(2013) Lucy A. Perrone et al.   JOURNAL OF INFECTIOUS DISEASES

Caspase-1 Deficient Mice Are More Susceptible to Influenza A Virus Infection With PA Variation

(2013) C.-H. Huang et al.   JOURNAL OF INFECTIOUS DISEASES

1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in Mice

(2013) T. Watanabe et al.   JOURNAL OF VIROLOGY

Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome

(2013) Yu Chen et al.   LANCET

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Biological features of novel avian influenza A (H7N9) virus

(2013) Jianfang Zhou et al.   NATURE

Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection

(2013) Hai-Nv Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phenotypic Differences in Virulence and Immune Response in Closely Related Clinical Isolates of Influenza A 2009 H1N1 Pandemic Viruses in Mice

(2013) Jeremy V. Camp et al.   PLoS One

Complement C5 Activation during Influenza A Infection in Mice Contributes to Neutrophil Recruitment and Lung Injury

(2013) Cristiana C. Garcia et al.   PLoS One

Infectivity, Transmission, and Pathology of Human-Isolated H7N9 Influenza Virus in Ferrets and Pigs

(2013) H. Zhu et al.   SCIENCE

Pattern recognition receptor function in neutrophils

(2013) Christina J. Thomas et al.   TRENDS IN IMMUNOLOGY

Targeting Neutrophil Apoptosis for Enhancing the Resolution of Inflammation

(2013) Driss El Kebir et al.   Cells

CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin

(2012) Akihiko Ichikawa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophils infected with highly virulent influenza H3N2 virus exhibit augmented early cell death and rapid induction of type I interferon signaling pathways

(2012) Fransiskus X. Ivan et al.   GENOMICS

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Cellular Targets of AhR Underlie Alterations in Neutrophilic Inflammation and Inducible Nitric Oxide Synthase Expression during Influenza Virus Infection

(2012) J. L. H. Wheeler et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Integrated Clinical, Pathologic, Virologic, and Transcriptomic Analysis of H5N1 Influenza Virus-Induced Viral Pneumonia in the Rhesus Macaque

(2012) K. Shinya et al.   JOURNAL OF VIROLOGY

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia

(2012) S L Poe et al.   Mucosal Immunology

Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung

(2012) O Dienz et al.   Mucosal Immunology

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

(2012) Masaki Imai et al.   NATURE

Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets

(2012) Judith M. A. van den Brand et al.   PLoS One

Influenza-Infected Neutrophils within the Infected Lungs Act as Antigen Presenting Cells for Anti-Viral CD8+ T Cells

(2012) Matthew M. Hufford et al.   PLoS One

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Pathogenesis of rhinovirus infection

(2012) Joshua L Kennedy et al.   Current Opinion in Virology

Pathogenesis of acute respiratory illness caused by human parainfluenza viruses

(2012) Henrick Schomacker et al.   Current Opinion in Virology

Matrix Metalloprotease 9 Mediates Neutrophil Migration into the Airways in Response to Influenza Virus-Induced Toll-Like Receptor Signaling

(2012) Linda M. Bradley et al.   PLoS Pathogens

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Exudate Macrophages Attenuate Lung Injury by the Release of IL-1 Receptor Antagonist in Gram-negative Pneumonia

(2011) Susanne Herold et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia

(2011) Nelson Lee et al.   ANTIVIRAL THERAPY

Genomic analysis of pandemic (H1N1) 2009 reveals association of increasing disease severity with emergence of novel hemagglutinin mutations

(2011) Gennadi V. Glinsky   CELL CYCLE

Human Metapneumovirus: Lessons Learned over the First Decade

(2011) V. Schildgen et al.   CLINICAL MICROBIOLOGY REVIEWS

The pathogenesis of influenza virus infections: the contributions of virus and host factors

(2011) Satoshi Fukuyama et al.   CURRENT OPINION IN IMMUNOLOGY

The role of TLRs in neutrophil activation

(2011) Lynne R Prince et al.   CURRENT OPINION IN PHARMACOLOGY

The ferret as a model organism to study influenza A virus infection

(2011) J. A. Belser et al.   Disease Models & Mechanisms

Genetic ablation of phagocytic NADPH oxidase in mice limits TNFα-induced inflammation in the lungs but not other tissues

(2011) Wei-Jian Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Neutrophils sustain effective CD8+ T-cell responses in the respiratory tract following influenza infection

(2011) Michelle D Tate et al.   IMMUNOLOGY AND CELL BIOLOGY

Introduction ofN-Linked Glycans in the Lectin Domain of Surfactant Protein D

(2011) Martin van Eijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Virulence determinants of pandemic influenza viruses

(2011) Donna M. Tscherne et al.   JOURNAL OF CLINICAL INVESTIGATION

NS1-mediated delay of type I interferon induction contributes to influenza A virulence in ferrets

(2011) I. Meunier et al.   JOURNAL OF GENERAL VIROLOGY

The 2009 Pandemic H1N1 D222G Hemagglutinin Mutation Alters Receptor Specificity and Increases Virulence in Mice but Not in Ferrets

(2011) Yacine Abed et al.   JOURNAL OF INFECTIOUS DISEASES

Local Innate Immune Responses and Influenza Virus Transmission and Virulence in Ferrets

(2011) Taronna R. Maines et al.   JOURNAL OF INFECTIOUS DISEASES

Interferon-Stimulated Genes and Their Protein Products: What and How?

(2011) Ernest C. Borden et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Cellular and molecular choreography of neutrophil recruitment to sites of sterile inflammation

(2011) Braedon McDonald et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Distinct Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury Pathways in Two Different Nonhuman Primate Species

(2011) S. L. Smits et al.   JOURNAL OF VIROLOGY

Evolutionary Dynamics of Local Pandemic H1N1/2009 Influenza Virus Lineages Revealed by Whole-Genome Analysis

(2011) G. J. Baillie et al.   JOURNAL OF VIROLOGY

Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection

(2011) Ryuichi Sugamata et al.   MICROBIOLOGY AND IMMUNOLOGY

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(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Influenza A viruses: new research developments

(2011) Rafael A. Medina et al.   NATURE REVIEWS MICROBIOLOGY

Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: Comparison with pediatric pneumonia without H1N1 2009 infection

(2011) Yeo Hyang Kim et al.   PEDIATRIC PULMONOLOGY

The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice

(2011) Michelle D. Tate et al.   PLoS One

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Large Scale Comparison of Innate Responses to Viral and Bacterial Pathogens in Mouse and Macaque

(2011) Guy Zinman et al.   PLoS One

Effect of D222G Mutation in the Hemagglutinin Protein on Receptor Binding, Pathogenesis and Transmissibility of the 2009 Pandemic H1N1 Influenza Virus

(2011) Jessica A. Belser et al.   PLoS One

Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults

(2011) Nelson Lee et al.   PLoS One

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Neutrophils in tuberculosis: friend or foe?

(2011) David M. Lowe et al.   TRENDS IN IMMUNOLOGY

The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding

(2011) Li Qi et al.   VIROLOGY

Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets

(2011) Isabelle Meunier et al.   VIROLOGY

Induction and evasion of type I interferon responses by influenza viruses

(2011) Adolfo García-Sastre   VIRUS RESEARCH

Neutrophils and interferon-α-producing cells: who produces interferon in lupus?

(2011) Patrice Decker   ARTHRITIS RESEARCH & THERAPY

2009 pandemic H1N1 influenza A virus strains display differential pathogenicity in C57BL/6J but not BALB/c mice

(2011) Anna Otte et al.   Virulence

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

(2011) Sang-Uk Seo et al.   PLoS Pathogens

Pathogenesis of the 1918 Pandemic Influenza Virus

(2011) Tokiko Watanabe et al.   PLoS Pathogens

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

(2011) Ross Vlahos et al.   PLoS Pathogens

Acute Lung Injury: How Macrophages Orchestrate Resolution of Inflammation and Tissue Repair

(2011) Susanne Herold et al.   Frontiers in Immunology

2009 Pandemic Influenza A (H1N1)

(2010) Wun-Ju Shieh et al.   AMERICAN JOURNAL OF PATHOLOGY

Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection

(2010) R. Zarychanski et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Delayed Clearance of Viral Load and Marked Cytokine Activation in Severe Cases of Pandemic H1N1 2009 Influenza Virus Infection

(2010) Kelvin K. W. To et al.   CLINICAL INFECTIOUS DISEASES

Epidemiology of 2009 Pandemic Influenza A (H1N1) in the United States

(2010) Michael A. Jhung et al.   CLINICAL INFECTIOUS DISEASES

Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection

(2010) T. Takano et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Human lung innate immune cytokine response to adenovirus type 7

(2010) W. Wu et al.   JOURNAL OF GENERAL VIROLOGY

Type I IFN Receptor Regulates Neutrophil Functions and Innate Immunity to Leishmania Parasites

(2010) L. Xin et al.   JOURNAL OF IMMUNOLOGY

Severity of Pneumonia Due to New H1N1 Influenza Virus in Ferrets Is Intermediate between That Due to Seasonal H1N1 Virus and Highly Pathogenic Avian Influenza H5N1 Virus

(2010) Judith M. A. van den Brand et al.   JOURNAL OF INFECTIOUS DISEASES

Mice Lacking Both TNF and IL‐1 Receptors Exhibit Reduced Lung Inflammation and Delay in Onset of Death following Infection with a Highly Virulent H5N1 Virus

(2010) Lucy A. Perrone et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism

(2010) Jean-Christophe Simard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genomic Profiling of Tumor Necrosis Factor Alpha (TNF- ) Receptor and Interleukin-1 Receptor Knockout Mice Reveals a Link between TNF-  Signaling and Increased Severity of 1918 Pandemic Influenza Virus Infection

(2010) S. E. Belisle et al.   JOURNAL OF VIROLOGY

Virulence-Associated Substitution D222G in the Hemagglutinin of 2009 Pandemic Influenza A(H1N1) Virus Affects Receptor Binding

(2010) S. Chutinimitkul et al.   JOURNAL OF VIROLOGY

MyD88 Signaling Is Indispensable for Primary Influenza A Virus Infection but Dispensable for Secondary Infection

(2010) S.-U. Seo et al.   JOURNAL OF VIROLOGY

Pandemic Swine-Origin H1N1 Influenza A Virus Isolates Show Heterogeneous Virulence in Macaques

(2010) D. Safronetz et al.   JOURNAL OF VIROLOGY

Postmortem findings in eight cases of influenza A/H1N1

(2010) Daniel G Rosen et al.   MODERN PATHOLOGY

Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4- and IFN-β-dependent

(2010) K A Shirey et al.   Mucosal Immunology

CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

(2010) Veronica Marcos et al.   NATURE MEDICINE

Pathology of the swine-origin influenza A (H1N1) flu

(2010) E.E. Calore et al.   PATHOLOGY RESEARCH AND PRACTICE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice

(2010) Rachel E. Foong et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009)

(2010) J. S. Nguyen-Van-Tam et al.   THORAX

Molecular and phylogenetic analysis of the haemagglutinin gene of pandemic influenza H1N1 2009 viruses associated with severe and fatal infections

(2010) Angeliki Melidou et al.   VIRUS RESEARCH

Animal Models for Influenza Virus Pathogenesis and Transmission

(2010) Nicole M. Bouvier et al.   Viruses-Basel

Variations in the Hemagglutinin of the 2009 H1N1 Pandemic Virus: Potential for Strains with Altered Virulence Phenotype?

(2010) Jianqiang Ye et al.   PLoS Pathogens

Comparison of cytokine responses in nasopharyngeal aspirates from children with viral lower respiratory tract infections

(2009) Jung Hye Byeon et al.   ACTA PAEDIATRICA

Imaging Findings in a Fatal Case of Pandemic Swine-Origin Influenza A (H1N1)

(2009) Daniel J. Mollura et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Chest Radiographic and CT Findings in Novel Swine-Origin Influenza A (H1N1) Virus (S-OIV) Infection

(2009) Prachi P. Agarwal et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Animal models for the study of influenza pathogenesis and therapy

(2009) Dale L. Barnard   ANTIVIRAL RESEARCH

Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species

(2009) Ahmed Lazrak et al.   FASEB JOURNAL

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

Factors Associated With Death or Hospitalization Due to Pandemic 2009 Influenza A(H1N1) Infection in California

(2009) Janice K. Louie   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans

(2009) J.S. Malik Peiris et al.   JOURNAL OF CLINICAL VIROLOGY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interactions of  -,  -, and  -Defensins with Influenza A Virus and Surfactant Protein D

(2009) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

(2009) M. D. Tate et al.   JOURNAL OF IMMUNOLOGY

Critical Role of IL-17RA in Immunopathology of Influenza Infection

(2009) C. R. Crowe et al.   JOURNAL OF IMMUNOLOGY

Cytokine Profiles Induced by the Novel Swine‐Origin Influenza A/H1N1 Virus: Implications for Treatment Strategies

(2009) Patrick C. Y. Woo et al.   JOURNAL OF INFECTIOUS DISEASES

Toll-Like Receptor Responses in IRAK-4-Deficient Neutrophils

(2009) Robin van Bruggen et al.   Journal of Innate Immunity

Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo

(2009) Q M Nhu et al.   Mucosal Immunology

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

(2009) Yasushi Itoh et al.   NATURE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico

(2009) Rogelio Perez-Padilla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) Virus Infection in China

(2009) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hospitalized Patients with 2009 H1N1 Influenza in the United States, April–June 2009

(2009) Seema Jain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pediatric Hospitalizations Associated with 2009 Pandemic Influenza A (H1N1) in Argentina

(2009) Romina Libster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice

(2009) Taronna R. Maines et al.   SCIENCE

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

An early ‘classical’ swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice

(2009) Matthew J. Memoli et al.   VIROLOGY

Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies

(2008) Fabrice Carrat et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Pathology, Molecular Biology, and Pathogenesis of Avian Influenza A (H5N1) Infection in Humans

(2008) Christine Korteweg et al.   AMERICAN JOURNAL OF PATHOLOGY

The Pathology of Influenza Virus Infections

(2008) Jeffery K. Taubenberger et al.   Annual Review of Pathology-Mechanisms of Disease

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

(2008) R. A. Dean et al.   BLOOD

Toll-like receptor-mediated activation of neutrophils by influenza A virus

(2008) J. P. Wang et al.   BLOOD

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Neutrophil Recruitment to the Lungs during Bacterial Pneumonia

(2008) A. Craig et al.   INFECTION AND IMMUNITY

Host immune responses to rhinovirus: Mechanisms in asthma

(2008) John T. Kelly et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

Respiratory Syncytial Virus Activates Innate Immunity through Toll-Like Receptor 2

(2008) M. R. Murawski et al.   JOURNAL OF VIROLOGY

Neutrophils Play an Essential Role in Cooperation with Antibody in both Protection against and Recovery from Pulmonary Infection with Influenza Virus in Mice

(2008) H. Fujisawa   JOURNAL OF VIROLOGY

Gene Expression Analysis of Host Innate Immune Responses during Lethal H5N1 Infection in Ferrets

(2008) C. M. Cameron et al.   JOURNAL OF VIROLOGY

Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin

(2008) Aarthi Chandrasekaran et al.   NATURE BIOTECHNOLOGY

Pathology of human influenza revisited

(2008) Thijs Kuiken et al.   VACCINE

Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction

(2008) Nicholas Svitek et al.   VIROLOGY