Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes

(2014) Min Wook So et al.   Modern Rheumatology

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

(2014) Didier Philipot et al.   ARTHRITIS RESEARCH & THERAPY

The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus

(2013) G. Daniele et al.   ACTA DIABETOLOGICA

Lipodystrophy-Linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction

(2013) Guillaume Bidault et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Peroxisome Proliferator-activated Receptor γ, Coactivator 1α Deletion Induces Angiotensin II–Associated Vascular Dysfunction by Increasing Mitochondrial Oxidative Stress and Vascular Inflammation

(2013) Swenja Kröller-Schön et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

1,25(OH)2D deficiency induces temporomandibular joint osteoarthritis via secretion of senescence-associated inflammatory cytokines

(2013) Ming Shen et al.   BONE

HMGA2 expression in white adipose tissue linking cellular senescence with diabetes

(2013) Dominique Nadine Markowski et al.   Genes and Nutrition

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Transmitting senescence to the cell neighbourhood

(2013) Matthew Hoare et al.   NATURE CELL BIOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

The roles of senescence and telomere shortening in cardiovascular disease

(2013) Frej Fyhrquist et al.   Nature Reviews Cardiology

XOMA 052, an anti-IL-1β monoclonal antibody, prevents IL-1β-mediated insulin resistance in 3T3-L1 adipocytes

(2013) Masahisa Handa et al.   Obesity

High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway

(2013) Rokhsana Mortuza et al.   PLoS One

Oncogene- and Oxidative Stress-Induced Cellular Senescence Shows Distinct Expression Patterns of Proinflammatory Cytokines in Vascular Endothelial Cells

(2013) Etsu Suzuki et al.   TheScientificWorldJOURNAL

Circulating inflamma-miRs in aging and age-related diseases

(2013) Fabiola Olivieri et al.   Frontiers in Genetics

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells

(2012) Simon Asbjørn Larsen et al.   Chemistry Central Journal

Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus

(2012) Alison L. Harte et al.   Experimental Diabetes Research

Translating advances from the basic biology of aging into clinical application

(2012) James L. Kirkland   EXPERIMENTAL GERONTOLOGY

Chronic Matrix Metalloproteinase Inhibition Retards Age-Associated Arterial Proinflammation and Increase in Blood Pressure

(2012) Mingyi Wang et al.   HYPERTENSION

Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters

(2012) Reilly T. Enos et al.   JOURNAL OF LIPID RESEARCH

Self-Renewal and Differentiation of Reactive Astrocyte-Derived Neural Stem/Progenitor Cells Isolated from the Cortical Peri-Infarct Area after Stroke

(2012) I. S. Shimada et al.   JOURNAL OF NEUROSCIENCE

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Repeated Lipopolysaccharide Stimulation Induces Cellular Senescence in BV2 Cells

(2012) Hong-Mei Yu et al.   NEUROIMMUNOMODULATION

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes

(2012) J. Rose et al.   OSTEOARTHRITIS AND CARTILAGE

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

The role of inflammatory processes in Alzheimer’s disease

(2012) G. Joseph Broussard et al.   INFLAMMOPHARMACOLOGY

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Protection of Tanshinone IIA to Human Peritoneal Mesothelial Cells (HPMC) through Delaying Cellular Senescence Induced by High Glucose

(2011) Dongwei Cao et al.   RENAL FAILURE

Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence

(2011) Lars-Gunnar Larsson   SEMINARS IN CANCER BIOLOGY

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Control of p53 and NF-κB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging

(2010) Antero Salminen et al.   CELLULAR SIGNALLING

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

The salted artery and angiotensin II signaling: a deadly duo in arterial disease

(2008) Mingyi Wang et al.   JOURNAL OF HYPERTENSION

Current concepts in the pathogenesis of osteoarthritis

(2008) S. Krasnokutsky et al.   OSTEOARTHRITIS AND CARTILAGE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Angiotensin II–Mediated Oxidative DNA Damage Accelerates Cellular Senescence in Cultured Human Vascular Smooth Muscle Cells via Telomere-Dependent and Independent Pathways

(2007) Karl E. Herbert et al.   CIRCULATION RESEARCH