Cathepsin K: The Action in and Beyond Bone

Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells

(2020) Mochihito Suzuki et al.   Scientific Reports

Cathepsin K Knockout Exacerbates Haemorrhagic Transformation Induced by Recombinant Tissue Plasminogen Activator After Focal Cerebral Ischaemia in Mice

(2019) Rong Zhao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cathepsin K–deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression

(2019) Sutada Lotinun et al.   JOURNAL OF CLINICAL INVESTIGATION

Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts

(2019) Jungeun Yu et al.   BONE

Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis

(2019) Philip G. Conaghan et al.   ANNALS OF INTERNAL MEDICINE

Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland

(2019) Stephanie Dauth et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

(2019) Michael R McClung et al.   Lancet Diabetes & Endocrinology

Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

(2018) Frank K. Leusink et al.   BMC CANCER

The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in the discovery of cathepsin K inhibitors on bone resorption

(2018) Jun Lu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

(2018) Erik Lindström et al.   Journal of Translational Medicine

Cathepsin K expression in clear cell “sugar” tumor (PEComa) of the lung

(2018) Anna Caliò et al.   VIRCHOWS ARCHIV

Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity

(2018) Rui Guo et al.   Cell Death & Disease

Discovery of a periosteal stem cell mediating intramembranous bone formation

(2018) Shawon Debnath et al.   NATURE

Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction

(2018) Wenqian Fang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned

(2017) Matthew T Drake et al.   ENDOCRINE REVIEWS

Cathepsin K Controls Cortical Bone Formation by Degrading Periostin

(2017) Nicolas Bonnet et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of cathepsin K in the development of chronic subdural hematoma

(2017) Satoshi Tsutsumi et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations inFaslprMice

(2017) Yi Zhou et al.   JOURNAL OF IMMUNOLOGY

Temporal Trends in Intravenous Thrombolysis in Acute Ischemic Stroke: Experience from a Tertiary Care Center in India

(2017) Dheeraj Khurana et al.   Journal of Stroke & Cerebrovascular Diseases

Cathepsin K knockout protects against cardiac dysfunction in diabetic mice

(2017) Rui Guo et al.   Scientific Reports

Temporal Trends in Intravenous Thrombolysis in Acute Ischemic Stroke: Experience from a Tertiary Care Center in India

(2017) Dheeraj Khurana et al.   Journal of Stroke & Cerebrovascular Diseases

Strategies to Extend Thrombolytic Time Window for Ischemic Stroke Treatment: An Unmet Clinical Need

(2017) Ike dela Peña et al.   Journal of Stroke

Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences

(2016) Dieter Brömme et al.   Expert Opinion on Drug Discovery

Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs

(2016) Hai-Tao Zhang et al.   Molecular Medicine Reports

Two pioneering osteoporosis drugs finally approach approval

(2016) Ken Garber   NATURE REVIEWS DRUG DISCOVERY

Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage

(2016) J.S. Mort et al.   OSTEOARTHRITIS AND CARTILAGE

Advances in the development of aptamer drug conjugates for targeted drug delivery

(2016) Ke Chen et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Cathepsin K knockout alleviates aging-induced cardiac dysfunction

(2015) Yinan Hua et al.   AGING CELL

A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts

(2015) Jin Liu et al.   BIOMATERIALS

Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role

(2015) Liang Hao et al.   FEBS LETTERS

Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis

(2015) Andre Kubler et al.   JOURNAL OF INFECTIOUS DISEASES

Increased expression and activation of cathepsin K in human osteoarthritic cartilage and synovial tissues

(2015) Eiji Kozawa et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings

(2015) Thomas Pap et al.   Nature Reviews Rheumatology

Increased Circulating Cathepsin K in Patients with Chronic Heart Failure

(2015) Guangxian Zhao et al.   PLoS One

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Circulating cathepsin K as a potential novel biomarker of coronary artery disease

(2013) Xian Wu Cheng et al.   ATHEROSCLEROSIS

Cathepsin K: a unique collagenolytic cysteine peptidase

(2013) Marko Novinec et al.   BIOLOGICAL CHEMISTRY

Vascular endothelial growth factors (VEGFs) and stroke

(2013) David A. Greenberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cathepsin K Knockout Alleviates Pressure Overload–Induced Cardiac Hypertrophy

(2013) Yinan Hua et al.   HYPERTENSION

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation

(2013) Sutada Lotinun et al.   JOURNAL OF CLINICAL INVESTIGATION

Cathepsin K Is Involved in Development of Psoriasis-like Skin Lesions through TLR-Dependent Th17 Activation

(2013) T. Hirai et al.   JOURNAL OF IMMUNOLOGY

Molecular Analysis of a Novel Cathepsin K Gene Mutation in a Chinese Child with Pycnodysostosis

(2013) H-Y Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Mechanisms With Clinical Implications for Atrial Fibrillation–Associated Remodeling: Cathepsin K Expression, Regulation, and Therapeutic Target and Biomarker

(2013) Masaya Fujita et al.   Journal of the American Heart Association

Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice

(2012) Stephanie Dauth et al.   BIOLOGICAL CHEMISTRY

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

(2012) Tadashi Hayami et al.   BONE

Cathepsin K Knockout Mitigates High-Fat Diet-Induced Cardiac Hypertrophy and Contractile Dysfunction

(2012) Y. Hua et al.   DIABETES

A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy

(2012) Ge Zhang et al.   NATURE MEDICINE

Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage

(2012) Valeria M Dejica et al.   ARTHRITIS RESEARCH & THERAPY

Cathepsin K Deficiency Reduces Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

(2011) Jiusong Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

(2011) Stephanie Dauth et al.   BMC NEUROSCIENCE

The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking

(2011) P. Leung et al.   BONE

Inhibitors of cathepsin K: a patent review (2004 – 2010)

(2011) Jac Wijkmans et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Hemodynamic mechanisms underlying cerebral aneurysm pathogenesis

(2011) David L. Penn et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib

(2011) Thomas M. Rnger et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis

(2011) Aline G. Costa et al.   Nature Reviews Rheumatology

Craniosynostosis in pycnodysostosis: Broadening the spectrum of the cranial flat bone abnormalities

(2010) Débora Bertola et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Denosumab and bisphosphonates: Different mechanisms of action and effects

(2010) Roland Baron et al.   BONE

Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis

(2010) J.J. McDougall et al.   OSTEOARTHRITIS AND CARTILAGE

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

(2009) Silvia Jordans et al.   BMC BIOCHEMISTRY

Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice

(2009) Lena Svelander et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Expression and regulation of cathepsin K in skin fibroblasts

(2009) Maria J. Quintanilla-Dieck et al.   EXPERIMENTAL DERMATOLOGY

ROLE FOR CATHEPSIN K IN EMPHYSEMA IN SMOKE-EXPOSED GUINEA PIGS

(2009) Polina Golovatch et al.   EXPERIMENTAL LUNG RESEARCH

Cathepsin K inhibitors for osteoporosis and potential off-target effects

(2009) Dieter Brömme et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand

(2009) Wayne Balkan et al.   GENE

The Matricellular Protein Periostin Is Required forSostInhibition and the Anabolic Response to Mechanical Loading and Physical Activity

(2009) Nicolas Bonnet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin K generates enkephalin from β-endorphin: A new mechanism with possible relevance for schizophrenia

(2009) Uwe Lendeckel et al.   NEUROCHEMISTRY INTERNATIONAL

Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

(2009) J.R. Connor et al.   OSTEOARTHRITIS AND CARTILAGE

Deficiency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice

(2008) Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone density, strength, and formation in adult cathepsin K (−/−) mice

(2008) B. Pennypacker et al.   BONE

Mechanisms of the Anabolic Effects of Teriparatide on Bone: Insight From the Treatment of a Patient With Pycnodysostosis

(2008) Pascale Chavassieux et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cathepsin K in Melanoma Invasion

(2008) Maria J. Quintanilla-Dieck et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Drug-induced morphea: Report of a case induced by balicatib and review of the literature

(2008) Anna Peroni et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cathepsin-k expression in pulmonary lymphangioleiomyomatosis

(2008) Marco Chilosi et al.   MODERN PATHOLOGY

Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

(2008) M. Asagiri et al.   SCIENCE

Cathepsin B, K, and S Are Expressed in Cerebral Aneurysms and Promote the Progression of Cerebral Aneurysms

(2008) Tomohiro Aoki et al.   STROKE

High Cathepsin K Levels in Men with Differentiated Thyroid Cancer on Suppressive l-Thyroxine Therapy

(2008) Peter Mikosch et al.   THYROID