Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences

Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

(2015) Vidhu Sharma et al.   BIOCHEMICAL JOURNAL

Effect of SI-591, a new class of cathepsin K inhibitor with peptidomimetic structure, on bone metabolism in vitro and in vivo

(2015) Toshiaki Fujii et al.   BONE

A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K

(2015) Preety Panwar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate

(2015) Mohd Parvez Khan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib increases mineralized callus during fracture healing in a rabbit ulnar osteotomy model

(2015) Brenda L. Pennypacker et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Papilledema From Craniosynostosis in Pycnodysostosis

(2015) Sung-eun E. Kyung et al.   PEDIATRIC NEUROLOGY

Complexity of cancer protease biology: Cathepsin K expression and function in cancer progression

(2015) Urška Verbovšek et al.   SEMINARS IN CANCER BIOLOGY

Odanacatib: a review of its potential in the management of osteoporosis in postmenopausal women

(2015) Roland D. Chapurlat   Therapeutic Advances in Musculoskeletal Disease

Effects of eight-month treatment with ONO-5334, a cathepsin K inhibitor, on bone metabolism, strength and microstructure in ovariectomized cynomolgus monkeys

(2014) Yasuo Ochi et al.   BONE

Increased fracture callus mineralization and strength in cathepsin K knockout mice

(2014) Michael A. Gentile et al.   BONE

Inhibition of bone resorption by the cathepsin K inhibitor odanacatib is fully reversible

(2014) Y. Zhuo et al.   BONE

Treatment of postmenopausal osteoporosis with odanacatib

(2014) Roland D Chapurlat   EXPERT OPINION ON PHARMACOTHERAPY

Novel Mutation and White Matter Involvement in an Indian Child with Pycnodysostosis

(2014) Ankur Singh et al.   INDIAN JOURNAL OF PEDIATRICS

Efficacy and safety of odanacatib treatment for patients with osteoporosis: a meta-analysis

(2014) Shi Feng et al.   JOURNAL OF BONE AND MINERAL METABOLISM

RGD peptide conjugated liposomal drug delivery system for enhance therapeutic efficacy in treating bone metastasis from prostate cancer

(2014) Fangfang Wang et al.   JOURNAL OF CONTROLLED RELEASE

Salvia miltiorrhiza: An ancient Chinese herbal medicine as a source for anti-osteoporotic drugs

(2014) Yubo Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-Term Odanacatib Fracture Trial

(2014) H. G. Bone et al.   OSTEOPOROSIS INTERNATIONAL

Structural basis of collagen fiber degradation by cathepsin K

(2014) Adeleke H. Aguda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods

(2014) Marko Novinec et al.   Nature Communications

Exome sequencing identifies CTSK mutations in patients originally diagnosed as intermediate osteopetrosis

(2013) Alessandra Pangrazio et al.   BONE

A novel mutation in two families with pycnodysostosis

(2013) Taha R. Ozdemir et al.   CLINICAL DYSMORPHOLOGY

Antiangiogenic effects of marine sponge derived compounds on cancer

(2013) Kalimuthu Senthilkumar et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Potential Antiosteoporotic Agents from Plants: A Comprehensive Review

(2013) Min Jia et al.   Evidence-based Complementary and Alternative Medicine

Cathepsin K Knockout Alleviates Pressure Overload–Induced Cardiac Hypertrophy

(2013) Yinan Hua et al.   HYPERTENSION

Cathepsin K Activity Controls Injury-Related Vascular Repair in Mice

(2013) Lina Hu et al.   HYPERTENSION

The Effect of the Cathepsin K Inhibitor ONO-5334 on Trabecular and Cortical Bone in Postmenopausal Osteoporosis: The OCEAN Study

(2013) Klaus Engelke et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effect of ONO-5334 on Bone Mineral Density and Biochemical Markers of Bone Turnover in Postmenopausal Osteoporosis: 2-Year Results From the OCEAN Study

(2013) Richard Eastell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation

(2013) Sutada Lotinun et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis

(2013) Juliette Sage et al.   MATRIX BIOLOGY

Odanacatib in postmenopausal women with low bone mineral density: a review of current clinical evidence

(2013) Cristiano A. F. Zerbini et al.   Therapeutic Advances in Musculoskeletal Disease

Effect of the selective cathepsin K inhibitor MIV-711 on bone resorption and cartilage degradation biomarkers and on knee joint pathology in dogs subjected to partial medial meniscectomy, an experimental model of osteoarthritis

(2012) E. Lindstrom⁎ et al.   BONE

Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics - results from single oral dose studies in healthy volunteers

(2012) S. Aubrey Stoch et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Disruption of the V-ATPase Functionality as a Way to Uncouple Bone Formation and Resorption - A Novel Target for Treatment of Osteoporosis

(2012) C. S. Thudium et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Cathepsin K Knockout Mitigates High-Fat Diet-Induced Cardiac Hypertrophy and Contractile Dysfunction

(2012) Y. Hua et al.   DIABETES

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Five years of continued therapy in a phase 2 study

(2012) Bente Langdahl et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Obesity in pycnodysostosis due to UPD1: Possible effect of an imprinted gene on chromosome 1

(2011) Debora Bertola et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis

(2011) Eiji Kozawa et al.   ARTHRITIS AND RHEUMATISM

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

(2011) Stephanie Dauth et al.   BMC NEUROSCIENCE

Pycnodysostosis with craniosynostosis

(2011) Hugo P. Caracas et al.   CLINICAL DYSMORPHOLOGY

Cathepsin K deficiency aggravates lung injury in hyperoxia-exposed newborn mice

(2011) Jonni Knaapi et al.   EXPERIMENTAL LUNG RESEARCH

Discontinuation of odanacatib and other osteoporosis treatments: Here today and gone tomorrow?

(2011) Douglas C Bauer   JOURNAL OF BONE AND MINERAL RESEARCH

Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study

(2011) Richard Eastell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys

(2011) Patricia J Masarachia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

(2011) Tara Cusick et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pharmacodynamic Effects on Biochemical Markers of Bone Turnover and Pharmacokinetics of the Cathepsin K Inhibitor, ONO-5334, in an Ascending Multiple-Dose, Phase 1 Study

(2011) Shinichi Nagase et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib

(2011) Thomas M. Rnger et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis

(2011) Aline G. Costa et al.   Nature Reviews Rheumatology

"MY PKU": increasing self-management in patients with phenylketonuria. A randomized controlled trial

(2011) Amber E ten Hoedt et al.   Orphanet Journal of Rare Diseases

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

(2011) C. Jerome et al.   OSTEOPOROSIS INTERNATIONAL

Severe developmental bone phenotype in ClC-7 deficient mice

(2010) A.V. Neutzsky-Wulff et al.   DEVELOPMENTAL BIOLOGY

Craniosynostosis: A rare complication of pycnodysostosis

(2010) Sara Osimani et al.   European Journal of Medical Genetics

Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis?

(2010) Izabela Podgorski   Future Medicinal Chemistry

Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions

(2010) Maia M. Cherney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

(2010) John A Eisman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Near Normalization of Adult Height and Body Proportions by Growth Hormone in Pycnodysostosis

(2010) Anya Rothenbühler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The vacuolar ATPase in bone cells: a potential therapeutic target in osteoporosis

(2010) Feng-Lai Yuan et al.   MOLECULAR BIOLOGY REPORTS

Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools

(2009) Sylvie Desmarais et al.   BIOLOGICAL CHEMISTRY

Nanostructured polyelectrolyte multilayer drug delivery systems for bone metastasis prevention

(2009) Florence Daubiné et al.   BIOMATERIALS

Treatment with a Potent Cathepsin K Inhibitor Preserves Cortical and Trabecular Bone Mass in Ovariectomized Monkeys

(2009) G. B. Stroup et al.   CALCIFIED TISSUE INTERNATIONAL

Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

(2009) S A Stoch et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cathepsin K inhibitors for osteoporosis and potential off-target effects

(2009) Dieter Brömme et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Sustained delivery and efficacy of polymeric nanoparticles containing osteopontin and bone sialoprotein antisenses in rats with breast cancer bone metastasis

(2009) Victoria Elazar et al.   INTERNATIONAL JOURNAL OF CANCER

Odanacatib, a Cathepsin-K Inhibitor for Osteoporosis: A Two-Year Study in Postmenopausal Women With Low Bone Density

(2009) Henry G Bone et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The cathepsin K inhibitor AAE581 induces morphological changes in osteoclasts of treated patients

(2009) Daniel Chappard et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Cathepsin K generates enkephalin from β-endorphin: A new mechanism with possible relevance for schizophrenia

(2009) Uwe Lendeckel et al.   NEUROCHEMISTRY INTERNATIONAL

Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage

(2008) Valeria M. Dejica et al.   AMERICAN JOURNAL OF PATHOLOGY

Deficiency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice

(2008) Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor–transgenic mice

(2008) Uta Schurigt et al.   ARTHRITIS AND RHEUMATISM

Erosive arthritis in a patient with pycnodysostosis: An experiment of nature

(2008) Mari Ainola et al.   ARTHRITIS AND RHEUMATISM

Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice

(2008) Andriy O. Samokhin et al.   ATHEROSCLEROSIS

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bone density, strength, and formation in adult cathepsin K (−/−) mice

(2008) B. Pennypacker et al.   BONE

Severe Snoring in a Child with Pycnodysostosis Treated with a Bilateral Rib Graft

(2008) Natacha Teissier et al.   CLEFT PALATE-CRANIOFACIAL JOURNAL

Mechanisms of the Anabolic Effects of Teriparatide on Bone: Insight From the Treatment of a Patient With Pycnodysostosis

(2008) Pascale Chavassieux et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of the hemopexin domain of matrix metalloproteinases in cell migration

(2008) Antoine Dufour et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Crystal and Molecular Structures of a Cathepsin K:Chondroitin Sulfate Complex

(2008) Zhenqiang Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Drug-induced morphea: Report of a case induced by balicatib and review of the literature

(2008) Anna Peroni et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts

(2007) Karen Fuller et al.   BONE