Article
Clinical Neurology
Charith Cooray, Michal Karlinski, Adam Kobayashi, Peter Ringleb, Janika Korv, Mary J. Macleod, Anand Dixit, Elsa Azevedo, Christopher Bladin, Niaz Ahmed
Summary: In acute ischemic stroke patients treated with intravenous thrombolysis, those with prestroke disability did not have a significantly increased risk of symptomatic intracerebral hemorrhage or parenchymal hemorrhage. However, they were associated with a higher risk of early mortality compared to patients without prestroke disability.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Pharmacology & Pharmacy
Maria Luz Alonso-Alonso, Maria Perez-Mato, Ana Sampedro-Viana, Clara Correa-Paz, Paulo Avila-Gomez, Tomas Sobrino, Francisco Campos, Jose Castillo, Ramon Iglesias-Rey, Pablo Hervella
Summary: In this study, a new dual MRI nanoparticle was developed to predict the efficacy of recanalization treatment and improve the triage of ischemic stroke patients by targeting the fibrin content of blood clots.
Article
Clinical Neurology
Ana Claudia de Souza, Ivy Anne Sebastian, Wan Asyraf Wan Zaidi, Ahmed Nasreldein, Danira Bazadona, Pablo Amaya, Ahmed Elkady, Meron Awraris Gebrewold, Pongpat Vorasayan, Nune Yeghiazaryan, Patrik Michel, Pooja Khatri, Jeyaraj Durai Pandian, Sheila Cristina Ouriques Martins, Werner Hacke, Vasileios-Arsenios Lioutas
Summary: The study revealed significant disparities in rtPA availability and pricing among countries, with lower income countries experiencing higher relative costs that exceed their available Health Expenditure. Concerted efforts to improve rtPA affordability in low-income settings are deemed necessary.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Neurosciences
Chunmiao Duan, Yunyun Xiong, Hong-Qiu Gu, Shang Wang, Kai-Xuan Yang, Manjun Hao, Xingquan Zhao, Xia Meng, Yongjun Wang
Summary: This study aimed to investigate the short-, medium-, and long-term outcomes of intravenous thrombolysis in minor stroke patients. The results suggest that intravenous thrombolysis may be safe and effective in improving functional outcomes in minor stroke patients within a 4.5-h window. However, further randomized controlled trials are needed for validation. The functional recovery rate in the overall study population ranged from 12.8% to 18.85%.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Navreet Kaur, Smit Patel, Michael Omoniyi Ayanbadejo, Haydn Hoffman, Emmanuel Akano, Nnabuchi Anikpezie, Ehimen Aneni, Oluwatomi Lamikanra, Claribel Wee, Karen Albright, Priyank Khandelwal, Julius Gene Latorre, Seemant Chaturvedi, Fadar Oliver Otite
Summary: This study evaluates the utilization trends of intravenous thrombolysis and mechanical thrombectomy in pediatric acute ischemic stroke in the United States. The findings show an increase in IV-tPA and MT utilization over the past decade, mainly in older children aged 10-17 years, while the utilization in children's hospitals did not change significantly over time.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Oncology
Yunyun Xiong, Ran Yan, Hongqiu Gu, Shang Wang, Marc Fisher, Xingquan Zhao, Xin Yang, Chunjuan Wang, Zhou Qi, Xia Meng, Zixiao Li, Yongjun Wang
Summary: This study investigated short-term outcomes and predictors for favorable functional outcome in mild stroke patients treated with rtPA in China. The results showed that only 18.5% of patients had an unfavorable functional outcome at discharge, with factors such as age, diabetes, time window, and NIHSS score being independent risk factors for poorer outcomes. The study suggests that rtPA is safe and effective for mild stroke patients, but further research is needed to confirm these findings.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Ganesh Asaithambi, Xin Tong, Sallyann M. Coleman King, Mary G. George
Summary: The study showed an increasing trend in the utilization of IVT among AIS patients with mild symptoms. Patients treated with IVT were more likely to be discharged to home and have the ability to ambulate independently at discharge.
CEREBROVASCULAR DISEASES
(2022)
Article
Clinical Neurology
Martha Marko, Dominika Miksova, Johanna Ebner, Marie Lang, Wolfgang Serles, Peter Sommer, Marek Sykora, Wilfried Lang, Michael Knoflach, Stefan Kiechl, Stefan Greisenegger
Summary: The study found that the frequency of favorable functional outcome in r-tPA-treated patients has been increasing over time, likely due to improved outcomes in patients with more severe strokes receiving endovascular treatment. However, some subgroups are still less likely to achieve functional independence and require particular attention.
Article
Medicine, General & Internal
Gabriel Broocks, Lukas Meyer, Celine Ruppert, Wolfgang Haupt, Tobias D. Faizy, Noel Van Horn, Matthias Bechstein, Helge Kniep, Sarah Elsayed, Andre Kemmling, Ewgenia Barow, Jens Fiehler, Uta Hanning
Summary: This study analyzed the impact of intravenous thrombolytic therapy (IVT) on functional outcome and secondary injury volumes in patients with complete reperfusion after thrombectomy. The results showed that bridging IVT was associated with a lower proportion of functional independence and a higher rate of symptomatic intracerebral hemorrhage (sICH). Multivariable analysis confirmed the independent association of bridging IVT with sICH and edema volume.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Angelos Sharobeam, Brett Jones, Dianne Walton-Sonda, Christian J. Lueck
Summary: This systematic review found that pre-hospital factors and in-hospital factors contribute to delays in thrombolysis administration, with long onset-to-needle times more common in certain patient groups. Various strategies exist to reduce delays, with processes integrating out-of-hospital and in-hospital processes showing the greatest improvements in time to thrombolysis.
JOURNAL OF NEUROLOGY
(2021)
Article
Emergency Medicine
Ganesh Asaithambi, Xin Tong, Kamakshi Lakshminarayan
Summary: The utilization of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) has been increasing in larger hospitals, while smaller hospitals use IVT less frequently or not at all. There was an overall improvement in door-to-needle times (DNTs), but only larger hospitals showed significant improvement in DNTs <= 45 min.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Clinical Neurology
Erik Simon, Matin Forghani, Andrij Abramyuk, Simon Winzer, Claudia Wojciechowski, Lars-Peder Pallesen, Timo Siepmann, Heinz Reichmann, Volker Puetz, Kristian Barlinn, Jessica Barlinn
Summary: This study evaluated the safety and short-term efficacy of intravenous thrombolysis (IVT) in acute ischemic stroke within an expanded time window delivered through a hub-and-spoke telestroke network. The results showed that IVT delivered through the telestroke network in the expanded time window was safe with equivalent short-term functional outcomes for patients admitted to spoke and hub centers.
FRONTIERS IN NEUROLOGY
(2021)
Article
Surgery
Amundeep S. Johal, A. Ross Naylor, Arun D. Pherwani, Qiuju Li, Panagiota Birmpili, Sam Waton, Richard O'Neill, Jonathan R. Boyle, David A. Cromwell
Summary: The study aimed to evaluate the effect of pre-operative intravenous thrombolytic therapy (ivTT) on short term outcomes after carotid endarterectomy (CEA) among patients who presented with ischemic stroke. Results showed that ivTT did not increase the risk of 30-day stroke after CEA in stroke patients, but there was an increased risk of neck hematoma.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Neurosciences
Chunmiao Duan, Yunyun Xiong, Hongqiu Gu, Shang Wang, Kai-Xuan Yang, Manjun Hao, Xueyan Feng, Xingquan Zhao, Xia Meng, Yongjun Wang
Summary: This study aimed to explore the effectiveness and safety of intravenous t-PA compared with dual antiplatelet therapy (DAPT) and aspirin alone for minor stroke with National Institutes of Health Stroke Scale (NIHSS) score <= 5 and large vessel occlusion (LVO). The results showed that intravenous t-PA was associated with better functional recovery and no symptomatic intracerebral hemorrhage within 36 hours, as compared with aspirin alone.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neuroimaging
Johannes M. Weller, Franziska Dorn, Gabor C. Petzold, Felix J. Bode
Summary: This study aimed to investigate the effect of ongoing intravenous thrombolysis (IVT) during flow restoration in patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy (ET). The results showed that ongoing IVT during flow restoration was associated with better functional outcomes at discharge and at 90 days.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)