Cancer Cell Metabolism Bolsters Immunotherapy Resistance by Promoting an Immunosuppressive Tumor Microenvironment
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cancer Cell Metabolism Bolsters Immunotherapy Resistance by Promoting an Immunosuppressive Tumor Microenvironment
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-07-22
DOI
10.3389/fonc.2020.01197
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
- (2020) Hong Liu et al. CANCER CELL
- Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal
- (2020) Tobias Baumann et al. NATURE IMMUNOLOGY
- Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
- (2020) Min-Hee Oh et al. JOURNAL OF CLINICAL INVESTIGATION
- CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
- (2019) Weimin Wang et al. NATURE
- Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer
- (2019) Cinzia Antognelli et al. Cells
- Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
- (2019) Robert D. Leone et al. SCIENCE
- Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer
- (2019) Lawrence Fong et al. Cancer Discovery
- Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer
- (2018) Lifeng Li et al. CANCER RESEARCH
- Autocrine Adenosine regulates tumor polyfunctional CD73+CD4+ effector T cells devoid of immune checkpoints
- (2018) Nicolas Gourdin et al. CANCER RESEARCH
- miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
- (2018) Meiying Luo et al. CELL DEATH AND DIFFERENTIATION
- Glyoxalases in Urological Malignancies
- (2018) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
- (2018) Lukas Bunse et al. NATURE MEDICINE
- L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a Nitric Oxide-Dependent Manner in C2C12 Cells
- (2018) Ruxia Wang et al. Oxidative Medicine and Cellular Longevity
- VEGF may contribute to macrophage recruitment and M2 polarization in the decidua
- (2018) Karen C. Wheeler et al. PLoS One
- Cancer immunotherapy using checkpoint blockade
- (2018) Antoni Ribas et al. SCIENCE
- Impact of l-Arginine Metabolism on Immune Response and Anticancer Immunotherapy
- (2018) Sun-Hee Kim et al. Frontiers in Oncology
- Combining Immune Checkpoint Inhibitors With Conventional Cancer Therapy
- (2018) Yiyi Yan et al. Frontiers in Immunology
- Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy
- (2018) Priyamvada Jayaprakash et al. JOURNAL OF CLINICAL INVESTIGATION
- Intracellular calcium and NF-kB regulate hypoxia-induced leptin, VEGF, IL-6 and adiponectin secretion in human adipocytes
- (2018) Azizah Al-Anazi et al. LIFE SCIENCES
- The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer
- (2017) Hanke L. Matlung et al. IMMUNOLOGICAL REVIEWS
- The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
- (2017) Bertrand Allard et al. IMMUNOLOGICAL REVIEWS
- COX2/mPGES1/PGE2pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells
- (2017) Victor Prima et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455
- (2017) Stefania Gessi et al. Frontiers in Pharmacology
- Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors
- (2017) Eva M. Palsson-McDermott et al. Frontiers in Immunology
- Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death
- (2017) Marie-Julie Nokin et al. Scientific Reports
- Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis
- (2016) D. Mittal et al. CANCER RESEARCH
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
- (2016) Willy Hugo et al. CELL
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab
- (2016) Benjamin Weide et al. CLINICAL CANCER RESEARCH
- Cancer metabolism: a therapeutic perspective
- (2016) Ubaldo E. Martinez-Outschoorn et al. Nature Reviews Clinical Oncology
- The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27
- (2016) Sènan M. d’Almeida et al. OncoImmunology
- Targeting CD73 in the tumor microenvironment with MEDI9447
- (2016) Carl M. Hay et al. OncoImmunology
- Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
- (2015) Shari Pilon-Thomas et al. CANCER RESEARCH
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Glutaminolysis and Transferrin Regulate Ferroptosis
- (2015) Minghui Gao et al. MOLECULAR CELL
- Quantification of tumor infiltrating Foxp3+ regulatory T cells enables the identification of high-risk patients for developing synchronous cancers over upper aerodigestive tract
- (2015) Wen-Lun Wang et al. ORAL ONCOLOGY
- HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
- (2015) Huimin Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma
- (2015) Fabienne Guillaumond et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model
- (2015) Claudia Sorrentino et al. Oncotarget
- CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer
- (2015) Kazumichi Yoshida et al. Cancer Medicine
- l-Arginine and its metabolites in kidney and cardiovascular disease
- (2014) Ada Popolo et al. AMINO ACIDS
- Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer
- (2014) George C. Prendergast et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- L-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells
- (2014) M. Fletcher et al. CANCER RESEARCH
- Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
- (2014) David O’Sullivan et al. IMMUNITY
- High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors
- (2014) Elisabet Aliagas et al. MEDIATORS OF INFLAMMATION
- Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
- (2014) J. Bastid et al. Cancer Immunology Research
- A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
- (2013) I. B. Barsoum et al. CANCER RESEARCH
- Acidity Generated by the Tumor Microenvironment Drives Local Invasion
- (2013) V. Estrella et al. CANCER RESEARCH
- Myeloid-derived suppressor cells in cancer: recent progress and prospects
- (2013) Yazan S Khaled et al. IMMUNOLOGY AND CELL BIOLOGY
- Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
- (2013) Linda V Sinclair et al. NATURE IMMUNOLOGY
- Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells
- (2013) Subhashis Sarkar et al. PLoS One
- Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors
- (2013) Paul A. Beavis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
- (2013) J. J. Kamphorst et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses
- (2013) Fenila Jacob et al. Purinergic Signalling
- An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
- (2013) D. Rohle et al. SCIENCE
- Immunogenic Cell Death in Cancer Therapy
- (2012) Guido Kroemer et al. Annual Review of Immunology
- Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion
- (2012) M. Platten et al. CANCER RESEARCH
- Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
- (2012) A. Calcinotto et al. CANCER RESEARCH
- Hypoxia-Inducible Factors in Physiology and Medicine
- (2012) Gregg L. Semenza CELL
- Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia
- (2012) K Morrow et al. LEUKEMIA
- Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
- (2012) Tracy L Keller et al. Nature Chemical Biology
- Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
- (2012) E. T. Clambey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide
- (2011) I. B. Barsoum et al. CANCER RESEARCH
- Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells
- (2011) S. Ryzhov et al. JOURNAL OF IMMUNOLOGY
- An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
- (2011) Christiane A. Opitz et al. NATURE
- Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
- (2011) Andrea Facciabene et al. NATURE
- Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
- (2011) Vinod P Balachandran et al. NATURE MEDICINE
- External influences on the immune system via activation of the aryl hydrocarbon receptor
- (2011) Brigitta Stockinger et al. SEMINARS IN IMMUNOLOGY
- Pegylated arginase I: a potential therapeutic approach in T-ALL
- (2010) C. P. Hernandez et al. BLOOD
- Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
- (2010) X. Liu et al. BLOOD
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Tumor pH and Its Measurement
- (2010) X. Zhang et al. JOURNAL OF NUCLEAR MEDICINE
- Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
- (2010) N. T. Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A2
- (2009) Jintang Sun et al. Cellular & Molecular Immunology
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
- (2008) Gennady G. Yegutkin BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Arginine Deprivation as a Targeted Therapy for Cancer
- (2008) L. Feun et al. CURRENT PHARMACEUTICAL DESIGN
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search