Regulation of DNA Damage Response and Homologous Recombination Repair by microRNA in Human Cells Exposed to Ionizing Radiation

Canonical DNA non-homologous end-joining; capacity versus fidelity

(2020) Atsushi Shibata et al.   BRITISH JOURNAL OF RADIOLOGY

PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications

(2020) Heng Zhu et al.   Molecular Cancer

Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells

(2020) Hongge Wang et al.   ONCOGENE

Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population

(2020) Moqin Qiu et al.   Biomed Research International

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

(2020) Tareq Saleh et al.   Cancers

Cancer Radiotherapy: Understanding the Price of Tumor Eradication

(2020) Olga A. Martin et al.   Frontiers in Cell and Developmental Biology

The genome-wide sequence preference of ionising radiation-induced cleavage in human DNA

(2019) Megan E. Hardie et al.   MOLECULAR BIOLOGY REPORTS

Cellular senescence in ionizing radiation (Review)

(2019) Zhengting Chen et al.   ONCOLOGY REPORTS

MiR-203 acts as a radiosensitizer of gastric cancer cells by directly targeting ZEB1

(2019) Ying Jiang et al.   OncoTargets and Therapy

Advances in the treatment of ovarian cancer using PARP inhibitors and the underlying mechanism of resistance

(2019) Ling Wang et al.   CURRENT DRUG TARGETS

Targeting the Hedgehog pathway in combination with X‑ray or carbon ion radiation decreases migration of MCF‑7 breast cancer cells

(2019) Katrien Konings et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies

(2019) Toma et al.   Cancers

Regulation of DNA repair in the absence of classical non-homologous end joining

(2018) Youn-Jung Kang et al.   DNA REPAIR

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways

(2018) Annahita Sallmyr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent

(2018) Steven T. Sizemore et al.   MOLECULAR CANCER RESEARCH

miRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation

(2018) Christianne Hoey et al.   Molecular Oncology

Regulation of miR-34b/c-targeted gene expression program by SUMOylation

(2018) Yi-Jia Li et al.   NUCLEIC ACIDS RESEARCH

The Sequence Preference of Gamma-Radiation-Induced Damage in End-Labeled DNA after Heat Treatment

(2018) Shweta D. Gautam et al.   RADIATION RESEARCH

Comprehensive network of miRNA-induced intergenic interactions and a biological role of its core in cancer

(2018) Vladimir V. Galatenko et al.   Scientific Reports

The Evolution of Radiation Therapy in Treating Cancer

(2018) Dorothy Abshire et al.   Seminars in Oncology Nursing

Alterations of MicroRNA Expression in the Liver, Heart, and Testis of Mice Upon Exposure to Repeated Low-Dose Radiation

(2018) Xinyue Liang et al.   Dose-Response

Functional validation of miRNAs targeting genes of DNA double-strand break repair to radiosensitize non-small lung cancer cells

(2018) Celeste Piotto et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cancer stem cells (CSCs) in cancer progression and therapy

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

miRNA Mediated Noise Making of 3′UTR Mutations in Cancer

(2018) Wei Wu et al.   Genes

RAD-ical New Insights into RAD51 Regulation

(2018) Meghan R. Sullivan et al.   Genes

Genetic variants in microRNA-binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx

(2017) Lijun Zhu et al.   INTERNATIONAL JOURNAL OF CANCER

NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle–dependent degradation of protein

(2017) Hui Zhou et al.   JOURNAL OF RADIATION RESEARCH

MiR-34a modulates ionizing radiation-induced senescence in lung cancer cells

(2017) Xiaoyuan He et al.   Oncotarget

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer

(2017) et al.   Cancers

miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3

(2016) Ying Zhou et al.   CANCER RESEARCH

Structure of the human dimeric ATM kinase

(2016) Wilson C. Y. Lau et al.   CELL CYCLE

Effects of radiation on metastasis and tumor cell migration

(2016) Marta Vilalta et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ovarian Cancers Harbor Defects in Nonhomologous End Joining Resulting in Resistance to Rucaparib

(2016) Aiste McCormick et al.   CLINICAL CANCER RESEARCH

Is Senescence Reversible?

(2016) Shweta Chakradeo et al.   CURRENT DRUG TARGETS

Cancer stem cells

(2016) Jeremy N. Rich   MEDICINE

Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells

(2016) Moureq Alotaibi et al.   RADIATION RESEARCH

Evolution and Biological Roles of Alternative 3′UTRs

(2016) Christine Mayr   TRENDS IN CELL BIOLOGY

A genetic basis for the variation in the vulnerability of cancer to DNA damage

(2016) Brian D. Yard et al.   Nature Communications

Low-dose irradiation promotes Rad51 expression by down-regulating miR-193b-3p in hepatocytes

(2016) Eon-Seok Lee et al.   Scientific Reports

Premature aging/senescence in cancer cells facing therapy: good or bad?

(2015) Llilians Calvo Gonzalez et al.   BIOGERONTOLOGY

MicroRNA-138 Regulates DNA Damage Response in Small Cell Lung Cancer Cells by Directly Targeting H2AX

(2015) Huan Yang et al.   CANCER INVESTIGATION

Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer

(2015) Gissela Borrego-Soto et al.   GENETICS AND MOLECULAR BIOLOGY

Error-Prone Repair of DNA Double-Strand Breaks

(2015) Kasey Rodgers et al.   JOURNAL OF CELLULAR PHYSIOLOGY

YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors

(2015) G. C. Stachelek et al.   MOLECULAR CANCER RESEARCH

MicroRNA-18a enhances the radiosensitivity of cervical cancer cells by promoting radiation-induced apoptosis

(2015) SHA LIU et al.   ONCOLOGY REPORTS

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52

(2015) William A. Gaines et al.   Nature Communications

Epigenetic changes in BRCA1-mutated familial breast cancer

(2015) Bradley Downs et al.   Cancer Genetics

miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma

(2015) Luqing Zhao et al.   Oncotarget

Double-strand break repair and colorectal cancer: gene variants within 3′ UTRs and microRNAs binding as modulators of cancer risk and clinical outcome

(2015) Alessio Naccarati et al.   Oncotarget

DNA repair mechanisms in cancer development and therapy

(2015) Alessandro Torgovnick et al.   Frontiers in Genetics

Genome-wide comparison of microRNAs and their targeted transcripts among leaf, flower and fruit of sweet orange

(2014) Yuanlong Liu et al.   BMC GENOMICS

Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase

(2014) Kumar Somyajit et al.   CARCINOGENESIS

A Functional Screen Identifies miRs That Induce Radioresistance in Glioblastomas

(2014) P. Moskwa et al.   MOLECULAR CANCER RESEARCH

Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation

(2014) P. Gasparini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability

(2014) Young Eun Choi et al.   eLife

microRNAs in Cancer Cell Response to Ionizing Radiation

(2013) Jennifer R. Czochor et al.   ANTIOXIDANTS & REDOX SIGNALING

Ionizing Radiation-Induced DNA Damage, Response, and Repair

(2013) Wil L. Santivasi et al.   ANTIOXIDANTS & REDOX SIGNALING

MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways

(2013) N Wu et al.   BRITISH JOURNAL OF CANCER

Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR

(2013) Sebastian Schulz et al.   CELLULAR SIGNALLING

Estrogen Receptor   Regulates ATM Expression through miRNAs in Breast Cancer

(2013) X. Guo et al.   CLINICAL CANCER RESEARCH

miR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cells

(2013) Yixuan Liu et al.   DNA REPAIR

MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia–telangiectasia mutated

(2013) Pin Guo et al.   EXPERIMENTAL CELL RESEARCH

The DNA-Damage Response to γ-Radiation Is Affected by miR-27a in A549 Cells

(2013) Andrea Di Francesco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of radiation-induced microRNA transcriptome by next-generation massively parallel sequencing

(2013) M. Ahmad Chaudhry et al.   JOURNAL OF RADIATION RESEARCH

Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity

(2013) J.-W. Huang et al.   MOLECULAR CANCER RESEARCH

miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase

(2013) Yunfei Zhou et al.   Molecular Oncology

Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress

(2013) M D Wallace et al.   ONCOGENE

Interaction between NBS1 and the mTOR/Rictor/SIN1 Complex through Specific Domains

(2013) Jian-Qiu Wang et al.   PLoS One

Obesity, Independent of p53 Gene Dosage, Promotes Mammary Tumor Progression and Upregulates the p53 Regulator MicroRNA-504

(2013) Nikki A. Ford et al.   PLoS One

MiR-34a is up-regulated in response to low dose, low energy X-ray induced DNA damage in breast cells

(2013) Luiza Stankevicins et al.   Radiation Oncology

Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up

(2013) Julien Vignard et al.   RADIOTHERAPY AND ONCOLOGY

Repair of Strand Breaks by Homologous Recombination

(2013) M. Jasin et al.   Cold Spring Harbor Perspectives in Biology

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

(2013) J. Cadet et al.   Cold Spring Harbor Perspectives in Biology

Acquisition of epithelial–mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance

(2013) L Chang et al.   Cell Death & Disease

A Novel Regulator of Macrophage Activation

(2012) Guoqing Zhuang et al.   CIRCULATION

Mechanisms of free radical-induced damage to DNA

(2012) Miral Dizdaroglu et al.   FREE RADICAL RESEARCH

MiR-34a in Age and Tissue Related Radio-Sensitivity and Serum miR-34a as a Novel Indicator of Radiation Injury

(2012) Cong Liu et al.   International Journal of Biological Sciences

MicroRNA-302 Replacement Therapy Sensitizes Breast Cancer Cells to Ionizing Radiation

(2012) Zhongxing Liang et al.   PHARMACEUTICAL RESEARCH

Advances in radiotherapy

(2012) S. S. Ahmad et al.   BMJ-British Medical Journal

A Map of Minor Groove Shape and Electrostatic Potential from Hydroxyl Radical Cleavage Patterns of DNA

(2011) Eric P. Bishop et al.   ACS Chemical Biology

Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells

(2011) Imran A. Babar et al.   CANCER BIOLOGY & THERAPY

The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes

(2011) Mark T.W. Teo et al.   CARCINOGENESIS

Presynaptic filament dynamics in homologous recombination and DNA repair

(2011) Jie Liu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer

(2011) Norimitsu Tanaka et al.   LUNG CANCER

MicroRNA-138 Modulates DNA Damage Response by Repressing Histone H2AX Expression

(2011) Y. Wang et al.   MOLECULAR CANCER RESEARCH

Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155

(2011) Suhwan Chang et al.   NATURE MEDICINE

Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum

(2011) M Tanori et al.   ONCOGENE

MicroRNA expression profiles in human cancer cells after ionizing radiation

(2011) Olivier M Niemoeller et al.   Radiation Oncology

Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq

(2011) P. J. Shepard et al.   RNA

MicroRNA Dysregulation in Human Thyroid Cells Following Exposure to Ionizing Radiation

(2011) Marina N. Nikiforova et al.   THYROID

Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair

(2011) Libing Song et al.   Journal of Molecular Cell Biology

Break-Induced Replication Is Highly Inaccurate

(2011) Angela Deem et al.   PLOS BIOLOGY

Loss of ATM/Chk2/p53 Pathway Components Accelerates Tumor Development and Contributes to Radiation Resistance in Gliomas

(2010) Massimo Squatrito et al.   CANCER CELL

Mechanism of p53 stabilization by ATM after DNA damage

(2010) Qian Cheng et al.   CELL CYCLE

Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J

(2010) Wooi Loon Ng et al.   DNA REPAIR

The MRN complex in double-strand break repair and telomere maintenance

(2010) Brandon J. Lamarche et al.   FEBS LETTERS

Increased Chromosomal Radiosensitivity in Women Carrying BRCA1/BRCA2 Mutations Assessed With the G2 Assay

(2010) Beroukas Ernestos et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Autophosphorylation and ATM Activation

(2010) Sergei V. Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

(2010) Patryk Moskwa et al.   MOLECULAR CELL

Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation

(2010) Dan Yan et al.   PLoS One

ATM is down-regulated by N-Myc-regulated microRNA-421

(2010) H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

(2010) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

(2010) W. M. Hicks et al.   SCIENCE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

MicroRNA-125b is a novel negative regulator of p53

(2009) M. T.N. Le et al.   GENES & DEVELOPMENT

Identification of ionizing radiation-responsive microRNAs in the IM9 human B lymphoblastic cell line

(2009) An   INTERNATIONAL JOURNAL OF ONCOLOGY

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

miR-24–mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells

(2009) Ashish Lal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells

(2009) M Kato et al.   ONCOGENE

Ionizing Radiation-Induced Oxidative Stress Alters miRNA Expression

(2009) Nicole L. Simone et al.   PLoS One

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

(2008) Longchuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY