Premature aging/senescence in cancer cells facing therapy: good or bad?

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Manipulating senescence in health and disease: emerging tools

(2015) Shuofei Cheng et al.   CELL CYCLE

Therapeutic targeting of replicative immortality

(2015) Paul Yaswen et al.   SEMINARS IN CANCER BIOLOGY

DDR-mediated crosstalk between DNA-damaged cells and their microenvironment

(2015) Nicolas Malaquin et al.   Frontiers in Genetics

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Translational research in oncology—10 years of progress and future prospects

(2014) James H. Doroshow et al.   Nature Reviews Clinical Oncology

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Decreased Skp2 Expression Is Necessary but Not Sufficient for Therapy-Induced Senescence in Prostate Cancer

(2014) Jonathan A. Ewald et al.   Translational Oncology

PKCη promotes senescence induced by oxidative stress and chemotherapy

(2014) U Zurgil et al.   Cell Death & Disease

Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells

(2013) Yu Zhu et al.   CANCER SCIENCE

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses

(2013) Timo Weiland et al.   INTERNATIONAL JOURNAL OF CANCER

Induction of p38  Expression Plays an Essential Role in Oncogenic ras-Induced Senescence

(2013) J. Kwong et al.   MOLECULAR AND CELLULAR BIOLOGY

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases

(2013) M Marxer et al.   ONCOGENE

Mitochondrial DNA damage induces apoptosis in senescent cells

(2013) R-M Laberge et al.   Cell Death & Disease

p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

(2012) James G. Jackson et al.   CANCER CELL

Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

(2012) L. Hoenicke et al.   CARCINOGENESIS

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence

(2012) Yan Liu et al.   EMBO Molecular Medicine

Pluripotent stem cells escape from senescence-associated DNA methylation changes

(2012) C. M. Koch et al.   GENOME RESEARCH

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Dexamethasone Reduces Sensitivity to Cisplatin by Blunting p53-Dependent Cellular Senescence in Non-Small Cell Lung Cancer

(2012) Haiyan Ge et al.   PLoS One

Senescence: a new weapon for cancer therapy

(2012) Juan Carlos Acosta et al.   TRENDS IN CELL BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape

(2011) Bernadett Papp et al.   CELL RESEARCH

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells

(2011) C Canino et al.   ONCOGENE

Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses

(2011) Qunfang Li et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

(2010) E. Galanis et al.   CANCER RESEARCH

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

Induced pluripotent stem cells and senescence: learning the biology to improve the technology

(2010) Ana Banito et al.   EMBO REPORTS

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Sunitinib Induces Apoptosis and Growth Arrest of Medulloblastoma Tumor Cells by Inhibiting STAT3 and AKT Signaling Pathways

(2010) F. Yang et al.   MOLECULAR CANCER RESEARCH

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

Aging increases p16INK4aexpression in vascular smooth-muscle cells

(2009) Luis Rodriguez‑Menocal et al.   BIOSCIENCE REPORTS

Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf

(2009) Xiaohua Su et al.   EMBO JOURNAL

Senescence impairs successful reprogramming to pluripotent stem cells

(2009) A. Banito et al.   GENES & DEVELOPMENT

Real-time in vivo imaging of p16Ink4areveals cross talk with p53

(2009) Kimi Yamakoshi et al.   JOURNAL OF CELL BIOLOGY

p53 Deficiency Leads to Compensatory Up-Regulation of p16INK4a

(2009) W. F. Leong et al.   MOLECULAR CANCER RESEARCH

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Stem Cells, Their Niches and the Systemic Environment: An Aging Network

(2008) D. Drummond-Barbosa   GENETICS

Critical pathways in cellular senescence and immortalization revealed by gene expression profiling

(2008) A L Fridman et al.   ONCOGENE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY