Journal
ACS CHEMICAL BIOLOGY
Volume 6, Issue 12, Pages 1314-1320Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb200155t
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Funding
- National Institutes of Health [R01 HG003541, R01 GM30518, U54 CAl21852]
- USC
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DNA shape variation and the associated variation in minor groove electrostatic, potential are widely exploited by proteins for DNA recognition. Here we show that the hydroxyl radical cleavage pattern is a quantitative measure of DNA backbone solvent accessibility, minor groove width, and minor groove electrostatic potential, at single nucleotide resolution. We introduce maps of DNA shape and electrostatic potential as tools for understanding how proteins recognize binding sites in a genome. These maps reveal periodic structural signals in yeast and Drosophila genomic DNA sequences that are associated with positioned nucleosomes.
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