Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade

Genetic alterations of malignant pleural mesothelioma: association to tumor heterogeneity and overall survival

(2020) Lisa Quetel et al.   Molecular Oncology

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma

(2020) Arnaud Scherpereel et al.   EUROPEAN RESPIRATORY JOURNAL

PRMT5 silencing selectively affects MTAP ‐deleted mesothelioma: In vitro evidence of a novel promising approach

(2020) Marcella Barbarino et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Biology of Malignant Mesothelioma and the Relevance of Preclinical Models

(2020) Christophe Blanquart et al.   Frontiers in Oncology

ADAM10 mediates malignant pleural mesothelioma invasiveness

(2019) Christelle Sépult et al.   ONCOGENE

Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies

(2019) Fiona H Tan et al.   OncoTargets and Therapy

Pleural mesothelioma: tackling a deadly cancer

(2019) The Lancet Respiratory Medicine   Lancet Respiratory Medicine

Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications

(2019) Yuna Blum et al.   Nature Communications

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib

(2019) Irati Garmendia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

(2019) Anna-Mariya Kukuyan et al.   CANCER RESEARCH

Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines

(2019) Anna Lucia Fallacara et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SRC fine‐tunes ADAM10 shedding activity to promote pituitary adenoma cell progression

(2019) Jinxiang Huang et al.   FEBS Journal

A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor

(2019) Anna Lucia Fallacara et al.   Cancers

Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line

(2019) Francesco P Cammarata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EURACAN/IASLC proposals for updating the histologic classification of pleural mesothelioma: towards a more multidisciplinary approach.

(2019) Andrew G. Nicholson et al.   Journal of Thoracic Oncology

Translating mesothelioma molecular genomics and dependencies into precision oncology-based therapies

(2019) Trista K. Hinz et al.   SEMINARS IN CANCER BIOLOGY

Leptin Promotes Expression of EMT-Related Transcription Factors and Invasion in a Src and FAK-Dependent Pathway in MCF10A Mammary Epithelial Cells

(2019) Monserrat Olea-Flores et al.   Cells

Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway

(2019) Kosuke Ogawa et al.   Journal of Hematology & Oncology

Adenosine diphosphate regulates MMP2 and MMP9 activity in malignant mesothelioma cells

(2018) Antonella Muscella et al.   Annals of the New York Academy of Sciences

A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424

(2018) Victoria K Woodcock et al.   BRITISH JOURNAL OF CANCER

Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma

(2018) Rajani Kanteti et al.   CANCER BIOLOGY & THERAPY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of SRC family kinases facilitates anti-CTLA4 immunotherapy in head and neck squamous cell carcinoma

(2018) Guang-Tao Yu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heterogeneity in Malignant Pleural Mesothelioma

(2018) Kathrin Oehl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma

(2018) Tatsuhiro Sato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

(2018) Sabine Hoves et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progress in the Management of Malignant Pleural Mesothelioma in 2017

(2018) Amanda J. McCambridge et al.   Journal of Thoracic Oncology

Biomarker-Integrated Neoadjuvant Dasatinib Trial in Resectable Malignant Pleural Mesothelioma

(2018) Anne S. Tsao et al.   Journal of Thoracic Oncology

RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines

(2018) Francesca Pentimalli et al.   ONCOGENE

Periostin: A Matricellular Protein With Multiple Functions in Cancer Development and Progression

(2018) Laura González-González et al.   Frontiers in Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Current and Future Management of Malignant Mesothelioma : A Consensus Report from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer and Mesothelioma Applied Research Foundation

(2018) Anne S. Tsao et al.   Journal of Thoracic Oncology

Cell–Cell Mechanical Communication in Cancer

(2018) Samantha C. Schwager et al.   Cellular and Molecular Bioengineering

Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells

(2018) Giusy Tornillo et al.   Cell Reports

ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma

(2018) Kai Li et al.   CANCER LETTERS

A review of bevacizumab in the treatment of malignant pleural mesothelioma

(2017) Solenn Brosseau et al.   Future Oncology

Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells

(2017) Alexia I. Bachir et al.   Cold Spring Harbor Perspectives in Biology

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective

(2017) Matthias Rübsam et al.   Cold Spring Harbor Perspectives in Biology

LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis

(2017) Elaine Ngan et al.   Nature Communications

TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways

(2017) Yuhui Wang et al.   Oncotarget

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling

(2017) Amy Dwyer et al.   Cancers

LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia

(2016) Phuong-Hien Nguyen et al.   CANCER CELL

Gap junction as an intercellular glue: Emerging roles in cancer EMT and metastasis

(2016) Xiao-Yuan Mao et al.   CANCER LETTERS

Clinical Pharmacokinetics and Pharmacodynamics of Bosutinib

(2016) Richat Abbas et al.   CLINICAL PHARMACOKINETICS

The Third Italian Consensus Conference for Malignant Pleural Mesothelioma: State of the art and recommendations

(2016) S. Novello et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration

(2016) Paola Indovina et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification

(2016) Francoise Galateau-Salle et al.   Journal of Thoracic Oncology

Environmental risk of mesothelioma in the United States: An emerging concern—epidemiological issues

(2016) Francine Baumann et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial

(2016) Gérard Zalcman et al.   LANCET

Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

(2016) Alessia Calgani et al.   MOLECULAR CANCER THERAPEUTICS

RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma

(2016) Huanzi Dai et al.   Cell Death & Disease

Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines

(2016) Valentina Monica et al.   Oncotarget

A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies

(2016) Ilaria Laurenzana et al.   Frontiers in Pharmacology

Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis

(2015) Masato Enomoto et al.   CANCER SCIENCE

Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion

(2015) Nikola Vlahov et al.   CURRENT BIOLOGY

SRC Family Kinase Inhibition Through a New Pyrazolo[3,4-d]Pyrimidine Derivative as a Feasible Approach for Glioblastoma Treatment

(2015) Elisa Ceccherini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hippo Pathway Gene Mutations in Malignant Mesothelioma: Revealed by RNA and Targeted Exon Sequencing

(2015) Akihiko Miyanaga et al.   Journal of Thoracic Oncology

High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma

(2015) Masaki Nasu et al.   Journal of Thoracic Oncology

Inhibition of Src family kinases overcomes anoikis resistance induced by spheroid formation and facilitates cisplatin-induced apoptosis in human mesothelioma cells

(2015) RYOJI EGUCHI et al.   ONCOLOGY REPORTS

Fyn is an important molecule in cancer pathogenesis and drug resistance

(2015) Daniel Elias et al.   PHARMACOLOGICAL RESEARCH

Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells

(2015) Tanushree Chatterji et al.   Oncotarget

SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation

(2015) Nadia Casini et al.   Oncotarget

Mesothelioma treatment: Are we on target? A review

(2015) Birgitta I. Hiddinga et al.   Journal of Advanced Research

CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells

(2014) Eriko Komiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multipoint targeting of the PI3K/mTOR pathway in mesothelioma

(2014) S Zhou et al.   BRITISH JOURNAL OF CANCER

Cross-talk between EphA2 and BRaf/CRaf Is a Key Determinant of Response to Dasatinib

(2014) J. Huang et al.   CLINICAL CANCER RESEARCH

Induction of proline-rich tyrosine kinase 2 activation-mediated C6 glioma cell invasion after anti-vascular endothelial growth factor therapy

(2014) Cheng-Shi Xu et al.   Journal of Translational Medicine

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

(2014) I. M. Shapiro et al.   Science Translational Medicine

Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation

(2014) M Cioce et al.   Cell Death & Disease

EphB4 as a therapeutic target in mesothelioma

(2013) Ren Liu et al.   BMC CANCER

Dynamic Regulation of the Structure and Functions of Integrin Adhesions

(2013) Haguy Wolfenson et al.   DEVELOPMENTAL CELL

A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies

(2013) Aung Naing et al.   INVESTIGATIONAL NEW DRUGS

Antitumor Effects of Immunotoxins Are Enhanced by Lowering HCK or Treatment with Src Kinase Inhibitors

(2013) X.-F. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Invading one step at a time: the role of invadopodia in tumor metastasis

(2013) H Paz et al.   ONCOGENE

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

(2013) Deborah Huveldt et al.   PLoS One

Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells

(2012) R. Eguchi et al.   CARCINOGENESIS

Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition

(2012) Martina Cozzi et al.   CELL CYCLE

New Strategies in Pleural Mesothelioma: BAP1 and NF2 as Novel Targets for Therapeutic Development and Risk Assessment

(2012) M. Ladanyi et al.   CLINICAL CANCER RESEARCH

Src-mediated regulation of E-cadherin and EMT in pancreatic cancer

(2012) Nagaraj et al.   Frontiers in Bioscience-Landmark

Regulation of the Src Family Kinases by Csk

(2012) Masato Okada   International Journal of Biological Sciences

Phase II Study of Dasatinib in Patients with Previously Treated Malignant Mesothelioma (Cancer and Leukemia Group B 30601): A Brief Report

(2012) Arkadiusz Z. Dudek et al.   Journal of Thoracic Oncology

Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer

(2012) Martin Klammer et al.   MOLECULAR & CELLULAR PROTEOMICS

Yes is a central mediator of cell growth in malignant mesothelioma cells

(2012) AYAMI SATO et al.   ONCOLOGY REPORTS

Nuclear localization of Matrix metalloproteinases

(2012) Ferdinando Mannello et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Simultaneous targeting of Src kinase and receptor tyrosine kinase results in synergistic inhibition of renal cell carcinoma proliferation and migration

(2011) Lanfang Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase

(2011) D. Kitagawa et al.   JOURNAL OF BIOCHEMISTRY

Germline BAP1 mutations predispose to malignant mesothelioma

(2011) Joseph R Testa et al.   NATURE GENETICS

New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization

(2011) P Indovina et al.   ONCOGENE

Current Status of Src Inhibitors in Solid Tumor Malignancies

(2011) L. N. Puls et al.   ONCOLOGIST

Differential transformation capacity of Src family kinases during the initiation of prostate cancer

(2011) H. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Src family kinases in anti-cancer therapies: turning promise into triumph

(2011) Siyuan Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Bowman-Birk protease inhibitor from soybeans enhances cisplatin-induced cytotoxicity in human mesothelioma cells

(2011) KOREHITO KASHIWAGI et al.   Experimental and Therapeutic Medicine

Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis

(2010) Xiaofeng Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

Novel dual Src/Abl inhibitors for hematologic and solid malignancies

(2010) Silvia Schenone et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration

(2010) Myeong Gu Yeo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

(2010) Jiannong Li et al.   Nature Chemical Biology

Activity of the multikinase inhibitor dasatinib against ovarian cancer cells

(2009) G E Konecny et al.   BRITISH JOURNAL OF CANCER

Malignant pleural mesothelioma cells resist anoikis as quiescent pluricellular aggregates

(2009) J Daubriac et al.   CELL DEATH AND DIFFERENTIATION

Prognostic significance of epithelial–mesenchymal transition in malignant pleural mesothelioma☆☆☆

(2009) Alexandra Schramm et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Enhanced Effect of Connexin 43 on Cisplatin-Induced Cytotoxicity in Mesothelioma Cells

(2009) Hiromi Sato et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells

(2009) Korehito Kashiwagi et al.   LIFE SCIENCES

The Role of Src in Solid Tumors

(2009) D. L. Wheeler et al.   ONCOLOGIST

Targeting Src in breast cancer

(2008) R. S. Finn   ANNALS OF ONCOLOGY

Lysophosphatidic acid induces ovarian cancer cell dispersal by activating Fyn kinase associated with p120-catenin

(2008) Ruby Yun-Ju Huang et al.   INTERNATIONAL JOURNAL OF CANCER