Invading one step at a time: the role of invadopodia in tumor metastasis

A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies

(2013) Aung Naing et al.   INVESTIGATIONAL NEW DRUGS

Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia

(2013) Begoña Díaz et al.   JOURNAL OF CELL BIOLOGY

β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation

(2013) Brian T. Beaty et al.   MOLECULAR BIOLOGY OF THE CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

p120RasGAP-Mediated Activation of c-Src Is Critical for Oncogenic Ras to Induce Tumor Invasion

(2012) P.-C. Chan et al.   CANCER RESEARCH

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

(2012) María Pilar Sánchez-Bailón et al.   CELLULAR SIGNALLING

Radioimmunotherapy of Fibroblast Activation Protein Positive Tumors by Rapidly Internalizing Antibodies

(2012) E. Fischer et al.   CLINICAL CANCER RESEARCH

Pathological roles of invadopodia in cancer invasion and metastasis

(2012) Hideki Yamaguchi   EUROPEAN JOURNAL OF CELL BIOLOGY

Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Ubiquitination at Lys581Increases Cellular Invasion through Type I Collagen

(2012) Patricia A. Eisenach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition

(2012) Jeanine Pignatelli et al.   JOURNAL OF CELL BIOLOGY

N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods

(2012) Xinzi Yu et al.   JOURNAL OF CELL BIOLOGY

N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors

(2012) B. Gligorijevic et al.   JOURNAL OF CELL SCIENCE

Perspective: The right trials

(2012) Patricia S. Steeg   NATURE

Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo

(2012) H Gil-Henn et al.   ONCOGENE

Adhesion rings surround invadopodia and promote maturation

(2012) K. M. Branch et al.   Biology Open

Sensing and Modulation of Invadopodia across a Wide Range of Rigidities

(2011) Aron Parekh et al.   BIOPHYSICAL JOURNAL

KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer

(2011) Muralidharan Anbalagan et al.   BREAST CANCER RESEARCH AND TREATMENT

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

(2011) Mark A. Eckert et al.   CANCER CELL

An EGFR-Src-Arg-Cortactin Pathway Mediates Functional Maturation of Invadopodia and Breast Cancer Cell Invasion

(2011) C. C. Mader et al.   CANCER RESEARCH

Cancer Cell-Associated MT1-MMP Promotes Blood Vessel Invasion and Distant Metastasis in Triple-Negative Mammary Tumors

(2011) J. Y. Perentes et al.   CANCER RESEARCH

Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain

(2011) B. Basu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ADAM12 Transmembrane and Secreted Isoforms Promote Breast Tumor Growth

(2011) Roopali Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer

(2011) E. T. Roussos et al.   JOURNAL OF CELL SCIENCE

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Current Status of Src Inhibitors in Solid Tumor Malignancies

(2011) L. N. Puls et al.   ONCOLOGIST

Advances in Targeting Src in the Treatment of Breast Cancer and Other Solid Malignancies

(2010) E. L. Mayer et al.   CLINICAL CANCER RESEARCH

Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity

(2010) Reidar Albrechtsen et al.   EXPERIMENTAL CELL RESEARCH

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

(2010) Chrisostomi Gialeli et al.   FEBS Journal

Abl Kinases Are Required for Invadopodia Formation and Chemokine-induced Invasion

(2010) Pameeka S. Smith-Pearson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation

(2010) L. C. Kelley et al.   JOURNAL OF CELL SCIENCE

Visualizing extravasation dynamics of metastatic tumor cells

(2010) K. Stoletov et al.   JOURNAL OF CELL SCIENCE

β1A Integrin Is a Master Regulator of Invadosome Organization and Function

(2010) Olivier Destaing et al.   MOLECULAR BIOLOGY OF THE CELL

c-Src differentially regulates the functions of microtentacles and invadopodia

(2010) E M Balzer et al.   ONCOGENE

 1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression

(2010) L. Huck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Metastasis: tumor cells becoming MENAcing

(2010) Frank Gertler et al.   TRENDS IN CELL BIOLOGY

Regulation of cancer invasiveness by the physical extracellular matrix environment

(2010) Aron Parekh et al.   Cell Adhesion & Migration

Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma

(2009) Robert M Eager et al.   BMC CANCER

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation

(2009) Luca Crimaldi et al.   EXPERIMENTAL CELL RESEARCH

The road to integrative cancer therapies: emergence of a tumor-associated fibroblast protease as a potential therapeutic target in cancer

(2009) Ellen Puré   EXPERT OPINION ON THERAPEUTIC TARGETS

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

(2009) Matthew Oser et al.   JOURNAL OF CELL BIOLOGY

Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia

(2009) R. Poincloux et al.   JOURNAL OF CELL SCIENCE

Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

(2009) Angélica M. Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

The Novel Adaptor Protein Tks4 (SH3PXD2B) Is Required for Functional Podosome Formation

(2009) Matthew D. Buschman et al.   MOLECULAR BIOLOGY OF THE CELL

Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

(2009) B. Diaz et al.   Science Signaling

Seprase: An overview of an important matrix serine protease

(2008) Pamela O'Brien et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cortactin in tumor invasiveness

(2008) Alissa M. Weaver   CANCER LETTERS

Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice

(2008) C. Nyalendo et al.   CARCINOGENESIS

Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo

(2008) Sumanta Goswami et al.   CLINICAL & EXPERIMENTAL METASTASIS

Extracellular Matrix Rigidity Promotes Invadopodia Activity

(2008) Nelson R. Alexander et al.   CURRENT BIOLOGY

MT1-MMP-Dependent Invasion Is Regulated by TI-VAMP/VAMP7

(2008) Anika Steffen et al.   CURRENT BIOLOGY

A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis

(2008) Ulrike Philippar et al.   DEVELOPMENTAL CELL

A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo

(2008) B BLOUW et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cellular roles of ADAM12 in health and disease

(2008) Marie Kveiborg et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sequential signals toward podosome formation in NIH-src cells

(2008) Tsukasa Oikawa et al.   JOURNAL OF CELL BIOLOGY

Activated c-Abl tyrosine kinase in malignant solid tumors

(2008) J Lin et al.   ONCOGENE

Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation

(2008) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA