SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration

SRC Family Kinase Inhibition Through a New Pyrazolo[3,4-d]Pyrimidine Derivative as a Feasible Approach for Glioblastoma Treatment

(2015) Elisa Ceccherini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

(2015) S Ventura et al.   ONCOGENE

RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy

(2015) Paola Indovina et al.   Oncotarget

SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation

(2015) Nadia Casini et al.   Oncotarget

Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing Sarcoma

(2014) J. Ban et al.   CANCER RESEARCH

The Genomic Landscape of Pediatric Ewing Sarcoma

(2014) B. D. Crompton et al.   Cancer Discovery

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

(2014) Andrew S. Brohl et al.   PLoS Genetics

Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant

(2013) Marco Radi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Notch signaling in pediatric soft tissue sarcomas

(2012) Rossella Rota et al.   BMC Medicine

Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition

(2012) Martina Cozzi et al.   CELL CYCLE

Emerging roles of RB family: New defense mechanisms against tumor progression

(2012) Paola Indovina et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Randomized Controlled Trial of Interval-Compressed Chemotherapy for the Treatment of Localized Ewing Sarcoma: A Report From the Children's Oncology Group

(2012) Richard B. Womer et al.   JOURNAL OF CLINICAL ONCOLOGY

The Tyrosine Kinase c-Src Directly Mediates Growth Factor-Induced Notch-1 and Furin Interaction and Notch-1 Activation in Pancreatic Cancer Cells

(2012) Yong-Chao Ma et al.   PLoS One

Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21Cip1 expression and hampers tumour cell growth in vitro and in vivo

(2011) L Raimondi et al.   CELL DEATH AND DIFFERENTIATION

New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization

(2011) P Indovina et al.   ONCOGENE

Fenretinide-dependent upregulation of death receptors through ASK1 and p38α enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours

(2010) D E White et al.   BRITISH JOURNAL OF CANCER

Novel dual Src/Abl inhibitors for hematologic and solid malignancies

(2010) Silvia Schenone et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Long-term Survivors of Childhood Ewing Sarcoma: Report From the Childhood Cancer Survivor Study

(2010) J. P. Ginsberg et al.   JNCI-Journal of the National Cancer Institute

Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration

(2010) Vipin Yadav et al.   MOLECULAR CARCINOGENESIS

Downstream EWS/FLI1 - upstream Ewing's sarcoma

(2010) Heinrich Kovar   Genome Medicine

Ewing's sarcoma of the bone: ESMO Clinical Recommendations for diagnosis, treatment and follow-up

(2009) M. Paulussen et al.   ANNALS OF ONCOLOGY

Advances in Ewing's Sarcoma Research: Where Are We Now and What Lies Ahead?

(2009) J. L. Ordonez et al.   CANCER RESEARCH

Dose-Intensified Compared With Standard Chemotherapy for Nonmetastatic Ewing Sarcoma Family of Tumors: A Children's Oncology Group Study

(2009) Linda Granowetter et al.   JOURNAL OF CLINICAL ONCOLOGY

A Molecular Function Map of Ewing's Sarcoma

(2009) Maximilian Kauer et al.   PLoS One

EWS-FLI1 Suppresses NOTCH-Activated p53 in Ewing's Sarcoma

(2008) J. Ban et al.   CANCER RESEARCH

Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells

(2008) Adriano Spreafico et al.   FASEB JOURNAL

Src Directly Phosphorylates Bif-1 and Prevents Its Interaction with Bax and the Initiation of Anoikis

(2008) Hirohito Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma

(2008) H. Guan et al.   MOLECULAR CANCER THERAPEUTICS