Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells

The mechanical regulation of integrin–cadherin crosstalk organizes cells, signaling and forces

(2016) Keeley L. Mui et al.   JOURNAL OF CELL SCIENCE

The FAK–Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin

(2016) Vinay Swaminathan et al.   MOLECULAR BIOLOGY OF THE CELL

Rac1-Dependent Phosphorylation and Focal Adhesion Recruitment of Myosin IIA Regulates Migration and Mechanosensing

(2015) Ana M. Pasapera et al.   CURRENT BIOLOGY

Dynamic Visualization of α-Catenin Reveals Rapid, Reversible Conformation Switching between Tension States

(2015) Tae-Jin Kim et al.   CURRENT BIOLOGY

Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions

(2015) Yao Wu et al.   DEVELOPMENTAL CELL

Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras

(2015) Julie M. Bianchini et al.   JOURNAL OF CELL BIOLOGY

Visualizing the Interior Architecture of Focal Adhesions with High-Resolution Traction Maps

(2015) Masatoshi Morimatsu et al.   NANO LETTERS

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly

(2015) Colleen T. Skau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions

(2014) Hiroaki Hirata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cadherin Adhesion and Mechanotransduction

(2014) D.E. Leckband et al.   Annual Review of Cell and Developmental Biology

Force Transmission at Cell–Cell and Cell–Matrix Adhesions

(2014) Kris A. DeMali et al.   BIOCHEMISTRY

Protrusive Activity Guides Changes in Cell-Cell Tension during Epithelial Cell Scattering

(2014) Venkat Maruthamuthu et al.   BIOPHYSICAL JOURNAL

Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration

(2014) Danfeng Cai et al.   CELL

Integrin-Associated Complexes Form Hierarchically with Variable Stoichiometry in Nascent Adhesions

(2014) Alexia I. Bachir et al.   CURRENT BIOLOGY

Stressing the limits of focal adhesion mechanosensitivity

(2014) Patrick W Oakes et al.   CURRENT OPINION IN CELL BIOLOGY

A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell–cell adhesion

(2014) Christopher P. Toret et al.   JOURNAL OF CELL BIOLOGY

Different roles of cadherins in the assembly and structural integrity of the desmosome complex

(2014) Molly Lowndes et al.   JOURNAL OF CELL SCIENCE

 -Catenin cytomechanics - role in cadherin-dependent adhesion and mechanotransduction

(2014) A. K. Barry et al.   JOURNAL OF CELL SCIENCE

ERM proteins in cancer progression

(2014) J. Clucas et al.   JOURNAL OF CELL SCIENCE

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling

(2014) Masatoshi Takeichi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arp2/3 Inhibition Induces Amoeboid-Like Protrusions in MCF10A Epithelial Cells by Reduced Cytoskeletal-Membrane Coupling and Focal Adhesion Assembly

(2014) Yvonne Beckham et al.   PLoS One

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

Traction force microscopy in physics and biology

(2014) Robert W. Style et al.   Soft Matter

Force-dependent conformational switch of α-catenin controls vinculin binding

(2014) Mingxi Yao et al.   Nature Communications

Resolving the molecular mechanism of cadherin catch bond formation

(2014) Kristine Manibog et al.   Nature Communications

Pre-metazoan origins and evolution of the cadherin adhesome

(2014) P. S. Murray et al.   Biology Open

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

(2013) Alex Carisey et al.   CURRENT BIOLOGY

Principles of E-Cadherin Supramolecular Organization In Vivo

(2013) Binh-An Truong Quang et al.   CURRENT BIOLOGY

A Mummified Duck-Billed Dinosaur with a Soft-Tissue Cock’s Comb

(2013) Phil R. Bell et al.   CURRENT BIOLOGY

Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

(2013) Ingo Thievessen et al.   JOURNAL OF CELL BIOLOGY

Analysis of the local organization and dynamics of cellular actin networks

(2013) Weiwei Luo et al.   JOURNAL OF CELL BIOLOGY

The role of integrin-linked kinase in the molecular architecture of focal adhesions

(2013) N. Elad et al.   JOURNAL OF CELL SCIENCE

Cycling around cell-cell adhesion with Rho GTPase regulators

(2013) J. McCormack et al.   JOURNAL OF CELL SCIENCE

αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors

(2013) Scott D. Hansen et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Tension Sensors Report Forces Generated by Single Integrin Molecules in Living Cells

(2013) Masatoshi Morimatsu et al.   NANO LETTERS

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

α-Catenin and Vinculin Cooperate to Promote High E-cadherin-based Adhesion Strength

(2012) William A. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

The role of nectins in different types of cell-cell adhesion

(2012) Y. Rikitake et al.   JOURNAL OF CELL SCIENCE

United we stand – integrating the actin cytoskeleton and cell–matrix adhesions in cellular mechanotransduction

(2012) Ulrich S. Schwarz et al.   JOURNAL OF CELL SCIENCE

Cadherin-dependent mechanotransduction depends on ligand identity but not affinity

(2012) H. Tabdili et al.   JOURNAL OF CELL SCIENCE

A WAVE2–Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens

(2012) Suzie Verma et al.   MOLECULAR BIOLOGY OF THE CELL

Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

(2012) Aparna Ratheesh et al.   NATURE CELL BIOLOGY

Mechanical waves during tissue expansion

(2012) Xavier Serra-Picamal et al.   Nature Physics

The Integrin-Ligand Interaction Regulates Adhesion and Migration through a Molecular Clutch

(2012) Lingfeng Chen et al.   PLoS One

 E-catenin is an autoinhibited molecule that coactivates vinculin

(2012) H.-J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ideal, catch, and slip bonds in cadherin adhesion

(2012) S. Rakshit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force Generation, Transmission, and Integration during Cell and Tissue Morphogenesis

(2011) Thomas Lecuit et al.   Annual Review of Cell and Developmental Biology

Spatiotemporal Constraints on the Force-Dependent Growth of Focal Adhesions

(2011) Jonathan Stricker et al.   BIOPHYSICAL JOURNAL

Structure and function of focal adhesions

(2011) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube

(2011) P. Stockinger et al.   DEVELOPMENT

A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration

(2011) Gregory F. Weber et al.   DEVELOPMENTAL CELL

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

The secret life of α-catenin: Moonlighting in morphogenesis

(2011) Stephanie L. Maiden et al.   JOURNAL OF CELL BIOLOGY

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

A role for actin arcs in the leading-edge advance of migrating cells

(2011) Dylan T. Burnette et al.   NATURE CELL BIOLOGY

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

Collective cell guidance by cooperative intercellular forces

(2011) Dhananjay T. Tambe et al.   NATURE MATERIALS

Cell-ECM traction force modulates endogenous tension at cell-cell contacts

(2011) V. Maruthamuthu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

Strength Dependence of Cadherin-Mediated Adhesions

(2010) Benoit Ladoux et al.   BIOPHYSICAL JOURNAL

αE-catenin regulates actin dynamics independently of cadherin-mediated cell–cell adhesion

(2010) Jacqueline M. Benjamin et al.   JOURNAL OF CELL BIOLOGY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility

(2010) C. Martinez-Rico et al.   JOURNAL OF CELL SCIENCE

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography

(2010) Israel Patla et al.   NATURE CELL BIOLOGY

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens

(2010) Michael Smutny et al.   NATURE CELL BIOLOGY

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions

(2010) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

Rigidity-Dependent Cross Talk between Integrin and Cadherin Signaling

(2009) Jones Tsai et al.   BIOPHYSICAL JOURNAL

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Non-muscle myosin II takes centre stage in cell adhesion and migration

(2009) Miguel Vicente-Manzanares et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Integrin connections to the cytoskeleton through talin and vinculin

(2008) Wolfgang H. Ziegler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Biophysical Properties of Cadherin Bonds Do Not Predict Cell Sorting

(2008) Quanming Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

(2008) Margaret L. Gardel et al.   JOURNAL OF CELL BIOLOGY

A two-tiered mechanism for stabilization and immobilization of E-cadherin

(2008) Matthieu Cavey et al.   NATURE

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

(2008) Colin K. Choi et al.   NATURE CELL BIOLOGY

Comparative Dynamics of Retrograde Actin Flow and Focal Adhesions: Formation of Nascent Adhesions Triggers Transition from Fast to Slow Flow

(2008) Antonina Y. Alexandrova et al.   PLoS One

Structural and functional associations of apical junctions with cytoskeleton

(2007) Jun Miyoshi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES