LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

(2019) Xinhe Wang et al.   Acta Neuropathologica Communications

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

(2019) Gregor Bieri et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

(2019) Richard M. Meade et al.   Molecular Neurodegeneration

Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis

(2019) Michael X. Henderson et al.   NATURE NEUROSCIENCE

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

(2019) Michael X. Henderson et al.   Acta Neuropathologica Communications

LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

(2019) Daniel Ysselstein et al.   Nature Communications

Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson’s models

(2018) Atossa Shaltouki et al.   ACTA NEUROPATHOLOGICA

Is Lewy pathology in the human nervous system chiefly an indicator of neuronal protection or of toxicity?

(2018) Suzanne Chartier et al.   CELL AND TISSUE RESEARCH

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S-Parkinson’s disease

(2018) Diana Luz Juárez-Flores et al.   Journal of Translational Medicine

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

(2018) Ga Ram Jeong et al.   Molecular Neurodegeneration

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

(2018) Jason Schapansky et al.   NEUROBIOLOGY OF DISEASE

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

(2018) Sangjune Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

(2018) Diego Grassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-cell-autonomous actions of α-synuclein: Implications in glial synucleinopathies

(2018) Somin Lim et al.   PROGRESS IN NEUROBIOLOGY

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons

(2018) Michael X. Henderson et al.   Acta Neuropathologica Communications

Endolysosomal degradation of Tau and its role in glucocorticoid‐driven hippocampal malfunction

(2018) João Vaz‐Silva et al.   EMBO JOURNAL

14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein

(2018) Bing Wang et al.   JOURNAL OF NEUROSCIENCE

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

(2018) Tomoya Eguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

(2018) Eun-Jin Bae et al.   Nature Communications

LRRK2 and Rab GTPases

(2018) Suzanne R. Pfeffer   BIOCHEMICAL SOCIETY TRANSACTIONS

The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease

(2018) Noémie Cresto et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Bax, Bak and beyond - mitochondrial performance in apoptosis

(2017) Aida Peña-Blanco et al.   FEBS Journal

G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain

(2017) An Phu Tran Nguyen et al.   HUMAN MOLECULAR GENETICS

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

(2017) Zhiyong Liu et al.   HUMAN MOLECULAR GENETICS

A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments

(2017) Jérôme Stirnemann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease

(2017) Yumiko V. Taguchi et al.   JOURNAL OF NEUROSCIENCE

Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease

(2017) Tim E. Moors et al.   Molecular Neurodegeneration

Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature

(2017) Susanne A. Schneider et al.   MOVEMENT DISORDERS

A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy

(2017) Yu-Lan Cao et al.   NEUROBIOLOGY OF AGING

Modulating membrane binding of α-synuclein as a therapeutic strategy

(2017) André Pineda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

(2017) Victorio Martin Pozo Devoto et al.   Scientific Reports

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

(2017) Martin Steger et al.   eLife

Chaperone-Based Therapies for Disease Modification in Parkinson’s Disease

(2017) Erik L. Friesen et al.   Parkinsons Disease

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

(2017) Francesco Longo et al.   Acta Neuropathologica Communications

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

Rabs, Membrane Dynamics, and Parkinson's Disease

(2016) Bor Luen Tang   JOURNAL OF CELLULAR PHYSIOLOGY

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

(2016) Senthilkumar S. Karuppagounder et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Rab7 induces clearance of α-synuclein aggregates

(2016) Elisabeth Dinter et al.   JOURNAL OF NEUROCHEMISTRY

Activation of  -Glucocerebrosidase Reduces Pathological  -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons

(2016) J. R. Mazzulli et al.   JOURNAL OF NEUROSCIENCE

G2019S-LRRK2 Expression Augments  -Synuclein Sequestration into Inclusions in Neurons

(2016) L. A. Volpicelli-Daley et al.   JOURNAL OF NEUROSCIENCE

Motor and nonmotor heterogeneity of LRRK2 -related and idiopathic Parkinson's disease

(2016) Connie Marras et al.   MOVEMENT DISORDERS

Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

(2016) Giambattista Guaitoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

(2016) Gaia Skibinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson’s disease

(2016) Ching-Chi Chiu et al.   Oncotarget

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson’s disease

(2016) T. Q. Melo et al.   EXPERIMENTAL BRAIN RESEARCH

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

(2016) Tomoki Kuwahara et al.   Scientific Reports

GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A

(2015) Ting-Ting Du et al.   Autophagy

Two-pore channels at the intersection of endolysosomal membrane traffic

(2015) Jonathan S. Marchant et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations

(2015) Roy N. Alcalay et al.   BRAIN

α-Synuclein and Lewy pathology in Parkinsonʼs disease

(2015) Lorraine V. Kalia et al.   CURRENT OPINION IN NEUROLOGY

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

(2015) Anastasia G. Henry et al.   HUMAN MOLECULAR GENETICS

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

(2015) João P. L. Daher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular functions of Rab GTPases at a glance

(2015) Y. Zhen et al.   JOURNAL OF CELL SCIENCE

A53T Human  -Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration

(2015) L. Chen et al.   JOURNAL OF NEUROSCIENCE

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for  -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

(2015) F.-L. Tang et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

A cell culture model for monitoring α-synuclein cell-to-cell transfer

(2015) Juan F. Reyes et al.   NEUROBIOLOGY OF DISEASE

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

(2015) M. Yue et al.   NEUROBIOLOGY OF DISEASE

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease

(2015) Elpida Tsika et al.   NEUROBIOLOGY OF DISEASE

Differential effects of severe vs mild GBA mutations on Parkinson disease

(2015) Z. Gan-Or et al.   NEUROLOGY

Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease

(2015) Lorraine V. Kalia et al.   JAMA Neurology

Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage

(2014) K. Zhang et al.   EMBO REPORTS

Rab proteins: The key regulators of intracellular vesicle transport

(2014) Tanmay Bhuin et al.   EXPERIMENTAL CELL RESEARCH

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

(2014) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution

(2014) Adamantios Mamais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

(2014) L. N. Hockey et al.   JOURNAL OF CELL SCIENCE

Sphingolipid lysosomal storage disorders

(2014) Frances M. Platt   NATURE

Direct Visualization of CHIP-Mediated Degradation of Alpha-Synuclein In Vivo: Implications for PD Therapeutics

(2014) Hemi Dimant et al.   PLoS One

Abrogation of  -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

(2014) J. P. L. Daher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Saltatory conduction in unmyelinated axons: clustering of Na+ channels on lipid rafts enables micro-saltatory conduction in C-fibers

(2014) Ali Neishabouri et al.   Frontiers in Neuroanatomy

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death

(2014) Mathieu Bourdenx et al.   Frontiers in Neuroanatomy

Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse

(2014) Daniel J. Schuster et al.   Frontiers in Neuroanatomy

Does Uncoupling Protein 2 Expression Qualify as Marker of Disease Status in LRRK2-Associated Parkinson's Disease?

(2013) Anne Grünewald et al.   ANTIOXIDANTS & REDOX SIGNALING

Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration

(2013) L D Osellame et al.   BRITISH JOURNAL OF PHARMACOLOGY

Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

(2013) Fumitaka Kawakami et al.   FEBS Journal

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

(2013) Yu-Chin Su et al.   HUMAN MOLECULAR GENETICS

14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes

(2013) Z. Xu et al.   JOURNAL OF CELL SCIENCE

Parkinson disease phenotype in Ashkenazi jews with and withoutLRRK2G2019S mutations

(2013) Roy N. Alcalay et al.   MOVEMENT DISORDERS

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT

(2013) Helen Ling et al.   NEUROBIOLOGY OF AGING

A comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism

(2013) Joanne Trinh et al.   NEUROBIOLOGY OF AGING

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases

(2013) Adamantios Mamais et al.   NEUROBIOLOGY OF DISEASE

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

(2013) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human α-Synuclein

(2013) Theodore A. Sarafian et al.   PLoS One

Synucleins Antagonize Endoplasmic Reticulum Function to Modulate Dopamine Transporter Trafficking

(2013) Adam W. Oaks et al.   PLoS One

The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells

(2013) Lamia'a Bahnassawy et al.   STEM CELLS AND DEVELOPMENT

Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways

(2013) M. R. Cookson   Cold Spring Harbor Perspectives in Medicine

Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons

(2012) Salvatore J. Cherra et al.   AMERICAN JOURNAL OF PATHOLOGY

α-Synuclein oligomers and clinical implications for Parkinson disease

(2012) Lorraine V. Kalia et al.   ANNALS OF NEUROLOGY

Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease

(2012) Elisa Greggio   BIOCHEMICAL SOCIETY TRANSACTIONS

Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains

(2012) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

Neurodegenerative phenotypes in an A53T  -synuclein transgenic mouse model are independent of LRRK2

(2012) J. P. L. Daher et al.   HUMAN MOLECULAR GENETICS

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models

(2012) Patrícia Silva Guerreiro et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

(2012) Jingwen Niu et al.   JOURNAL OF NEUROCHEMISTRY

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease

(2012) Weilin Xie et al.   JOURNAL OF NEUROCHEMISTRY

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

(2012) Elodie Angot et al.   PLoS One

α-Synuclein phosphorylation as a therapeutic target in Parkinson’s disease

(2012) Steven P. Braithwaite et al.   REVIEWS IN THE NEUROSCIENCES

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

(2012) Z. Sheng et al.   Science Translational Medicine

Mitochondrial Quality Control and Dynamics in Parkinson's Disease

(2011) Melissa K. McCoy et al.   ANTIOXIDANTS & REDOX SIGNALING

α-Synuclein Aggregation and Transmission Are Enhanced by Leucine-Rich Repeat Kinase 2 in Human Neuroblastoma SH-SY5Y Cells

(2011) Kazunari Kondo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β

(2011) Fumitaka Kawakami et al.   FEBS Journal

Molecular mechanisms and physiologic functions of mitochondrial dynamics

(2011) H. Otera et al.   JOURNAL OF BIOCHEMISTRY

Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

(2011) Vinay Choubey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2

(2011) J. Dusonchet et al.   JOURNAL OF NEUROSCIENCE

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat

(2011) Jeffrey H. Kordower et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Atypical tauopathy in a patient with LRRK2-G2019S mutation and tremor-dominant Parkinsonism

(2011) C. Ruffmann et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson’s disease susceptibility?

(2011) Joanna M. Biernacka et al.   PARKINSONISM & RELATED DISORDERS

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5)

(2011) Lorraine V. Kalia et al.   PLoS One

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment

(2010) Anna Gomez et al.   ACTA NEUROPATHOLOGICA

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3 

(2010) C.-H. Lin et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

(2010) Elisa A. Waxman et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cell-to-cell transmission of non-prion protein aggregates

(2010) Seung-Jae Lee et al.   Nature Reviews Neurology

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease

(2010) T A Yacoubian et al.   Cell Death & Disease

Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions

(2009) Elisa Greggio et al.   ASN Neuro

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

(2009) Hong Qing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Mammalian macroautophagy at a glance

(2009) B. Ravikumar et al.   JOURNAL OF CELL SCIENCE

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?

(2009) Frank Gillardon   JOURNAL OF NEUROCHEMISTRY

Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila

(2009) C.-H. Ng et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

(2009) Han Seok Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

(2008) Marta Martinez-Vicente et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions

(2008) Melinda A. McFarland et al.   MOLECULAR & CELLULAR PROTEOMICS

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

(2008) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Leucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson’s Disease, but Not Tau-Containing Deposits in Tauopathies

(2008) George Perry et al.   Neurodegenerative Diseases

Complex I deficiency in Parkinson's disease frontal cortex

(2007) W. Davis Parker et al.   BRAIN RESEARCH

LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease

(2007) J. Alegre-Abarrategui et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY