LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models

The Role of Phosphorylation in Synucleinopathies: Focus on Parkinsons Disease

(2012) Nadia Cavallarin et al.   CNS & Neurological Disorders-Drug Targets

Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease

(2011) Jinxia Zhou et al.   ACTA NEUROPATHOLOGICA

Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?

(2011) Elisa Greggio et al.   Molecular Neurodegeneration

LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study

(2011) S. Sharma et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy

(2011) Nahuai Badiola et al.   PLoS One

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

Leucine-rich repeat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway

(2010) Iria Carballo-Carbajal et al.   CELLULAR SIGNALLING

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Identification and Characterization of a Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif

(2010) Pooja P. Pungaliya et al.   PLoS One

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

(2009) Hong Qing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mendelian forms of Parkinson's disease

(2009) Thomas Gasser   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Isoform-specific proteolysis of apolipoprotein-E in the brain

(2009) David A. Elliott et al.   NEUROBIOLOGY OF AGING

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology

(2008) Filip Simunovic et al.   BRAIN

Emerging pathways in genetic Parkinson’s disease: tangles, Lewy bodies and LRRK2

(2008) Michael J. Devine et al.   FEBS Journal

Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions

(2008) Melinda A. McFarland et al.   MOLECULAR & CELLULAR PROTEOMICS

Lrrk2 and α-synuclein are co-regulated in rodent striatum

(2008) Marie Westerlund et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Leucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson’s Disease, but Not Tau-Containing Deposits in Tauopathies

(2008) George Perry et al.   Neurodegenerative Diseases

LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease

(2007) J. Alegre-Abarrategui et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY