Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression
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Title
Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression
Authors
Keywords
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Journal
HUMAN MOLECULAR GENETICS
Volume 24, Issue 21, Pages 6013-6028
Publisher
Oxford University Press (OUP)
Online
2015-08-07
DOI
10.1093/hmg/ddv314
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Note: Only part of the references are listed.- LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity
- (2014) Patricia Gómez-Suaga et al. HUMAN MOLECULAR GENETICS
- HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes
- (2014) K. Li et al. JOURNAL OF CELL SCIENCE
- Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition
- (2014) L. N. Hockey et al. JOURNAL OF CELL SCIENCE
- Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor
- (2014) Jaclyn L. Henderson et al. JOURNAL OF MEDICINAL CHEMISTRY
- An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
- (2014) Y. Zhang et al. JOURNAL OF NEUROSCIENCE
- Analyzing 54,936 Samples Supports the Association Between CD2AP rs9349407 Polymorphism and Alzheimer’s Disease Susceptibility
- (2014) Hongyuan Chen et al. MOLECULAR NEUROBIOLOGY
- Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP
- (2014) E.E. Coffey et al. NEUROSCIENCE
- Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
- (2014) A. Beilina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endosome maturation, transport and functions
- (2014) Cameron C. Scott et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Role of Endosomes and Lysosomes in Human Disease
- (2014) F. R. Maxfield Cold Spring Harbor Perspectives in Biology
- LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status
- (2014) April Reynolds et al. Frontiers in Molecular Neuroscience
- Inhibition of LRRK2 kinase activity stimulates macroautophagy
- (2013) Claudia Manzoni et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies
- (2013) Claudia Manzoni et al. FASEB JOURNAL
- ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons
- (2013) Hideaki Matsui et al. FEBS LETTERS
- Lysosomal impairment in Parkinson's disease
- (2013) Benjamin Dehay et al. MOVEMENT DISORDERS
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- Signals from the lysosome: a control centre for cellular clearance and energy metabolism
- (2013) Carmine Settembre et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk
- (2013) David A. MacLeod et al. NEURON
- Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice
- (2013) Florian Giesert et al. PLoS One
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
- (2013) T. Wyss-Coray et al. Cold Spring Harbor Perspectives in Medicine
- ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies
- (2013) Karen E Murphy et al. Acta Neuropathologica Communications
- Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations
- (2012) Ryan D. Mills et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway
- (2012) José M. Bravo-San Pedro et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
- (2012) Adriana Sánchez-Danés et al. EMBO Molecular Medicine
- Lysosomal storage disorders: The cellular impact of lysosomal dysfunction
- (2012) Frances M. Platt et al. JOURNAL OF CELL BIOLOGY
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, -Synuclein Accumulation, and Neurotoxicity
- (2012) M. Usenovic et al. JOURNAL OF NEUROSCIENCE
- LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
- (2012) Kelly M Hinkle et al. Molecular Neurodegeneration
- Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
- (2012) Youren Tong et al. Molecular Neurodegeneration
- Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
- (2012) B. Dehay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
- (2012) Z. Sheng et al. Science Translational Medicine
- PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity
- (2011) David Ramonet et al. HUMAN MOLECULAR GENETICS
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
- (2011) Martin C. Herzig et al. HUMAN MOLECULAR GENETICS
- LRRK2 Parkinson disease mutations enhance its microtubule association
- (2011) Lauren R. Kett et al. HUMAN MOLECULAR GENETICS
- Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
- (2011) M. W. Dodson et al. HUMAN MOLECULAR GENETICS
- Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
- (2011) Patricia Gómez-Suaga et al. HUMAN MOLECULAR GENETICS
- LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool
- (2011) G. Piccoli et al. JOURNAL OF NEUROSCIENCE
- Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
- (2011) Xianming Deng et al. Nature Chemical Biology
- Astrocyte–neuron metabolic relationships: for better and for worse
- (2011) Igor Allaman et al. TRENDS IN NEUROSCIENCES
- The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity
- (2011) M Lichtenberg et al. Cell Death & Disease
- Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
- (2010) Lydia Alvarez-Erviti et al. ARCHIVES OF NEUROLOGY
- Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization
- (2010) Nicolas Dzamko et al. BIOCHEMICAL JOURNAL
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant
- (2010) Veronique Daniëls et al. JOURNAL OF NEUROCHEMISTRY
- Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S
- (2010) X. Li et al. JOURNAL OF NEUROSCIENCE
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- A QUICK Screen for Lrrk2 Interaction Partners – Leucine-rich Repeat Kinase 2 is Involved in Actin Cytoskeleton Dynamics
- (2010) Andrea Meixner et al. MOLECULAR & CELLULAR PROTEOMICS
- The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
- (2010) Mark R. Cookson NATURE REVIEWS NEUROSCIENCE
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice
- (2010) Xing-Long Gu et al. Molecular Brain
- Regulation Mechanisms and Signaling Pathways of Autophagy
- (2009) Congcong He et al. Annual Review of Genetics
- LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
- (2009) Javier Alegre-Abarrategui et al. HUMAN MOLECULAR GENETICS
- Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease
- (2009) Shinji Higashi et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
- (2009) L. Parisiadou et al. JOURNAL OF NEUROSCIENCE
- Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
- (2009) Paul Saftig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
- (2009) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- The Gly2019Ser mutation in LRRK2is not fully penetrant in familial Parkinson's disease: the GenePD study
- (2008) Jeanne C Latourelle et al. BMC Medicine
- LRRK2 regulates synaptic vesicle endocytosis
- (2008) Narae Shin et al. EXPERIMENTAL CELL RESEARCH
- Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
- (2008) Edward D. Plowey et al. JOURNAL OF NEUROCHEMISTRY
- The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
- (2008) Payal N. Gandhi et al. JOURNAL OF NEUROSCIENCE RESEARCH
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