MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases

Neuroinflammation, Microglia, and Cell-Association during Prion Disease

(2019) James Carroll et al.   Viruses-Basel

Systematic Review of miRNA as Biomarkers in Alzheimer’s Disease

(2019) S. Swarbrick et al.   MOLECULAR NEUROBIOLOGY

Neuroinflammation, the thread connecting neurological disease

(2019) Roberta Brambilla   ACTA NEUROPATHOLOGICA

Nanoparticle–microRNA-146a-5p polyplexes ameliorate diabetic peripheral neuropathy by modulating inflammation and apoptosis

(2019) Qiong Luo et al.   Nanomedicine-Nanotechnology Biology and Medicine

microRNA dysregulation in neurodegenerative diseases: A systematic review

(2019) Camille A. Juźwik et al.   PROGRESS IN NEUROBIOLOGY

Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity

(2019) Joana Gonçalves-Ribeiro et al.   Frontiers in Cellular Neuroscience

Association Between Toll‐Like Receptor 4 ( TLR4 ) and Triggering Receptor Expressed on Myeloid Cells 2 ( TREM2 ) Genetic Variants and Clinical Progression of Huntington's Disease

(2019) Romina Vuono et al.   MOVEMENT DISORDERS

Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model

(2019) Hui Mai et al.   Molecular Therapy-Nucleic Acids

The role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy

(2018) Tao-Ran Li et al.   Disease Models & Mechanisms

OUP accepted manuscript

(2018)   Labmedicine

miR-146a induces apoptosis in neuroblastoma cells by targeting BCL11A

(2018) Sheng-Hua Li et al.   MEDICAL HYPOTHESES

Antagonist targeting microRNA-146a protects against lithium-pilocarpine-induced status epilepticus in rats by nuclear factor-κB pathway

(2018) Huilong Zhang et al.   Molecular Medicine Reports

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model

(2018) Cátia Gomes et al.   MOLECULAR NEUROBIOLOGY

Commentary: Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2018) Thomas K. Karikari et al.   Frontiers in Neurology

OUP accepted manuscript

(2018)   LABORATORY MEDICINE

Increased serum microRNA-29b expression and bad recovery in Japanese encephalitis virus infected patients; A new component to improve the disease recovery

(2018) Manjari Baluni et al.   JOURNAL OF NEUROIMMUNOLOGY

Circulating microRNAs, Vascular Risk, and Physical Activity in Spinal Cord-Injured Subjects

(2018) Layde R. Paim et al.   JOURNAL OF NEUROTRAUMA

miRNA‑146a attenuates inflammation in an in�vitro spinal cord injury model via inhibition of TLR4 signaling

(2018) Ying Tan et al.   Experimental and Therapeutic Medicine

Association between polymorphisms in microRNAs and ischemic stroke in an Asian population: evidence based on 6,083 cases and 7,248 controls

(2018) Donghua Zou et al.   Clinical Interventions in Aging

Immature Exosomes Derived from MicroRNA-146a Overexpressing Dendritic Cells Act as Antigen-Specific Therapy for Myasthenia Gravis

(2017) Weifan Yin et al.   INFLAMMATION

Micro-RNAs in ALS muscle: Differences in gender, age at onset and disease duration

(2017) Valentina Pegoraro et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Acute and subacute microRNA dysregulation is associated with cytokine responses in the rodent model of penetrating ballistic-like brain injury

(2017) David Johnson et al.   Journal of Trauma and Acute Care Surgery

Regulatory effects of miR-146a/b on the function of endothelial progenitor cells in acute ischemic stroke in mice

(2017) Zeng-Feng Su et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model

(2017) Hua Tao et al.   MEDIATORS OF INFLAMMATION

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

(2017) Carolina Cunha et al.   MOLECULAR NEUROBIOLOGY

miRNAs in cerebrospinal fluid identify patients with MS and specifically those with lipid-specific oligoclonal IgM bands

(2017) Ester Quintana et al.   Multiple Sclerosis Journal

Decreased miR-146a expression in acute ischemic stroke directly targets the Fbxl10 mRNA and is involved in modulating apoptosis

(2017) Sheng-Hua Li et al.   NEUROCHEMISTRY INTERNATIONAL

Common genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis

(2017) Yuan Zhou et al.   NEUROLOGICAL SCIENCES

MiR-146a promotes remyelination in a cuprizone model of demyelinating injury

(2017) Jing Zhang et al.   NEUROSCIENCE

Myasthenia Gravis

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Acute and subacute microRNA dysregulation is associated with cytokine responses in the rodent model of penetrating ballistic-like brain injury

(2017) David Johnson et al.   Journal of Trauma and Acute Care Surgery

miRNAs in cerebrospinal fluid identify patients with MS and specifically those with lipid-specific oligoclonal IgM bands

(2017) Ester Quintana et al.   Multiple Sclerosis Journal

Induction of Multiple miR-200/182 Members in the Brains of Mice Are Associated with Acute Herpes Simplex Virus 1 Encephalitis

(2017) Anna Majer et al.   PLoS One

MicroRNA-146a down-regulation correlates with neuroprotection and targets pro-apoptotic genes in cerebral ischemic injury in vitro

(2016) Xia Zhou et al.   BRAIN RESEARCH

Serum miR-221 serves as a biomarker for Parkinson's disease

(2016) Wenbin Ma et al.   CELL BIOCHEMISTRY AND FUNCTION

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

(2016) Rodica Pop-Busui et al.   DIABETES CARE

MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1

(2016) Wenjing Liu et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-146a represses LRP2 translation and leads to cell apoptosis in Alzheimer's disease

(2016) Bei Zhang et al.   FEBS LETTERS

Validation of microRNAs in Cerebrospinal Fluid as Biomarkers for Different Forms of Dementia in a Multicenter Study

(2016) Mareike Müller et al.   JOURNAL OF ALZHEIMERS DISEASE

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

MicroRNA abundance is altered in synaptoneurosomes during prion disease

(2016) Amrit S. Boese et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

MicroRNA 146a locally mediates distal axonal growth of dorsal root ganglia neurons under high glucose and sildenafil conditions

(2016) Longfei Jia et al.   NEUROSCIENCE

Association of the genetic polymorphisms in pre-microRNAs with risk of childhood epilepsy in a Chinese population

(2016) Yang Li et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Over-Expressed Pathogenic miRNAs in Alzheimer’s Disease (AD) and Prion Disease (PrD) Drive Deficits in TREM2-Mediated Aβ42 Peptide Clearance

(2016) Yuhai Zhao et al.   Frontiers in Aging Neuroscience

MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression

(2016) Jinsong Wei et al.   Biomed Research International

The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein

(2016) Lisa Seipold et al.   Frontiers in Molecular Neuroscience

MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer’s disease

(2016) Gang Wang et al.   Scientific Reports

Pilocytic astrocytoma: pathology, molecular mechanisms and markers

(2015) V. Peter Collins et al.   ACTA NEUROPATHOLOGICA

Genetic Association ofMiR-146awith Multiple Sclerosis Susceptibility in the Chinese Population

(2015) You Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Differential Regulation of microRNAs in Patients with Ischemic Stroke

(2015) Sheng-Hua Li et al.   CURRENT NEUROVASCULAR RESEARCH

Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer’s Disease

(2015) Hui Dong et al.   DISEASE MARKERS

Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury

(2015) Wang-Xia Wang et al.   EXPERIMENTAL NEUROLOGY

Brain Endothelial miR-146a Negatively Modulates T-Cell Adhesion through Repressing Multiple Targets to Inhibit NF-κB Activation

(2015) Dongsheng Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

miR-146a suppresses cellular immune response during Japanese encephalitis virus JaOArS982 strain infection in human microglial cells

(2015) Nikhil Sharma et al.   Journal of Neuroinflammation

A single nucleotide polymorphism in primary-microRNA-146a reduces the expression of mature microRNA-146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease

(2015) BIN ZHANG et al.   Molecular Medicine Reports

Analysis of RNA from Alzheimer’s Disease Post-mortem Brain Tissues

(2015) Christian Clement et al.   MOLECULAR NEUROBIOLOGY

Association of Altered Serum MicroRNAs with Perihematomal Edema after Acute Intracerebral Hemorrhage

(2015) Ying Zhu et al.   PLoS One

A functional polymorphism of the microRNA-146a gene is associated with susceptibility to drug-resistant epilepsy and seizures frequency

(2015) Lili Cui et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy

(2015) Jun Wang et al.   Scientific Reports

MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy – comparison with human epileptic samples

(2015) Paolo Roncon et al.   Scientific Reports

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

(2015) Anmol Kumar et al.   PLoS Genetics

Increase in NF-κB-sensitive miRNA-146a and miRNA-155 in multiple sclerosis (MS) and pro-inflammatory neurodegeneration

(2015) Deidre J. Devier et al.   Frontiers in Molecular Neuroscience

Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways

(2015) Tania A. Jones et al.   Acta Neuropathologica Communications

MicroRNA and epilepsy

(2014) David C. Henshall   CURRENT OPINION IN NEUROLOGY

MicroRNA Therapeutics in Neurological Disease

(2014) David Greenberg et al.   CURRENT PHARMACEUTICAL DESIGN

Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis

(2014) JunMei Zhang et al.   IMMUNOLOGY

Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor

(2014) Kathleen Vrolix et al.   JOURNAL OF AUTOIMMUNITY

Thymosin β4 Up-regulation of MicroRNA-146a Promotes Oligodendrocyte Differentiation and Suppression of the Toll-like Proinflammatory Pathway

(2014) Manoranjan Santra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Functional Polymorphism in the Promoter Region of MicroRNA-146a Is Associated with the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Patients

(2014) Lili Cui et al.   PLoS One

Decreased Serum Level of miR-146a as Sign of Chronic Inflammation in Type 2 Diabetic Patients

(2014) Lucy Baldeón R. et al.   PLoS One

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

(2014) Viktoria Gudi et al.   Frontiers in Cellular Neuroscience

Functional Anatomy of Complement Factor H

(2013) Elisavet Makou et al.   BIOCHEMISTRY

Modulation of mGluR-Dependent MAP1B Translation and AMPA Receptor Endocytosis by MicroRNA miR-146a-5p

(2013) Y.-L. Chen et al.   JOURNAL OF NEUROSCIENCE

MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid

(2013) Mareike Müller et al.   NEUROBIOLOGY OF AGING

The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy

(2013) L. Wang et al.   NEUROSCIENCE

Altered expression of miR-146a in myasthenia gravis

(2013) Jiayin Lu et al.   NEUROSCIENCE LETTERS

Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels

(2013) Danae Campos-Melo et al.   Molecular Brain

Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials

(2013) Paul Gordon et al.   Aging and Disease

Combination Therapy With VELCADE and Tissue Plasminogen Activator Is Neuroprotective in Aged Rats After Stroke and Targets MicroRNA-146a and the Toll-Like Receptor Signaling Pathway

(2012) Li Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Astrocyte-derived GDNF is a potent inhibitor of microglial activation

(2012) Sandra Moreira Rocha et al.   NEUROBIOLOGY OF DISEASE

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

(2012) Reuben Saba et al.   PLoS One

New Insights into the Roles of Megalin/LRP2 and the Regulation of its Functional Expression

(2011) María-Paz Marzolo et al.   BIOLOGICAL RESEARCH

The Role of Immune and Inflammatory Mechanisms in ALS

(2011) P. A. McCombe et al.   CURRENT MOLECULAR MEDICINE

NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells

(2011) Walter J. Lukiw   EXPERIMENTAL NEUROLOGY

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

Upregulation of Micro RNA-146a (miRNA-146a), A Marker for Inflammatory Neurodegeneration, in Sporadic Creutzfeldt–Jakob Disease (sCJD) and Gerstmann–Straussler–Scheinker (GSS) Syndrome

(2011) W. J. Lukiw et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Complications of intracerebral haemorrhage

(2011) Joyce S Balami et al.   LANCET NEUROLOGY

Diabetic neuropathy: cellular mechanisms as therapeutic targets

(2011) Andrea M. Vincent et al.   Nature Reviews Neurology

Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells

(2011) Yuan Yuan Li et al.   NEUROSCIENCE LETTERS

Regulation of miR-146a by RelA/NFkB and p53 in STHdhQ111/HdhQ111 Cells, a Cell Model of Huntington's Disease

(2011) Jayeeta Ghose et al.   PLoS One

Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis

(2011) Anne Waschbisch et al.   PLoS One

Micro RNA -214,-150,-146a and-125b targetHuntingtingene

(2011) Mithun Sinha et al.   RNA Biology

Altered microRNAs in STHdhQ111/HdhQ111 cells: miR-146a targets TBP

(2010) Mithun Sinha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy

(2010) E. Aronica et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells

(2010) Slava Rom et al.   FASEB JOURNAL

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury

(2010) Jenna M. Ziebell et al.   Neurotherapeutics

A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing

(2010) Eulàlia Martí et al.   NUCLEIC ACIDS RESEARCH

Characterization of an NF-κB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells

(2009) Aileen I. Pogue et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Highly permissive infection of microglial cells by Japanese encephalitis virus: a possible role as a viral reservoir

(2009) Thananya Thongtan et al.   MICROBES AND INFECTION

HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling

(2009) James M. Hill et al.   NEUROREPORT

Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex

(2009) Prerna Sethi et al.   NEUROSCIENCE LETTERS

Huntington's disease: from pathology and genetics to potential therapies

(2008) Sara Imarisio et al.   BIOCHEMICAL JOURNAL

An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells

(2008) Walter J. Lukiw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammation

(2008) Enikö Sonkoly et al.   SEMINARS IN CANCER BIOLOGY