Neuroinflammation, Microglia, and Cell-Association during Prion Disease

Toll-like receptor 2 confers partial neuroprotection during prion disease

(2019) James A. Carroll et al.   PLoS One

Microglia Are Critical in Host Defense against Prion Disease

(2018) James A. Carroll et al.   JOURNAL OF VIROLOGY

Bindarit, Inhibitor of CCL2 Synthesis, Protects Neurons Against Amyloid-β-Induced Toxicity

(2018) Cinzia Severini et al.   JOURNAL OF ALZHEIMERS DISEASE

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Microglia in prion diseases

(2017) Adriano Aguzzi et al.   JOURNAL OF CLINICAL INVESTIGATION

Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice

(2017) James A. Carroll et al.   JOURNAL OF GENERAL VIROLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Atorvastatin in improvement of cognitive impairments caused by amyloid β in mice: involvement of inflammatory reaction

(2016) Liandong Zhao et al.   BMC Neurology

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

A neuroprotective role for microglia in prion diseases

(2016) Caihong Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Knockout of fractalkine receptor Cx3cr1 does not alter disease or microglial activation in prion-infected mice

(2016) James F. Striebel et al.   JOURNAL OF GENERAL VIROLOGY

Pleiotropic effects of statins: new therapeutic targets in drug design

(2016) Onkar Bedi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

Prion Strain Differences in Accumulation of PrPSc on Neurons and Glia Are Associated with Similar Expression Profiles of Neuroinflammatory Genes: Comparison of Three Prion Strains

(2016) James A. Carroll et al.   PLoS Pathogens

Microglia function during brain development: New insights from animal models

(2015) Parizad M. Bilimoria et al.   BRAIN RESEARCH

Statin Treatment in Multiple Sclerosis: A Systematic Review and Meta-Analysis

(2015) Gorm Pihl-Jensen et al.   CNS DRUGS

Frontotemporal lobar degeneration FTLD-tau: preclinical lesions, vascular, and Alzheimer-related co-pathologies

(2015) Dietmar Rudolf Thal et al.   JOURNAL OF NEURAL TRANSMISSION

Defining the Microglia Response during the Time Course of Chronic Neurodegeneration

(2015) James E. Vincenti et al.   JOURNAL OF VIROLOGY

Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective study

(2015) Xuemei Huang et al.   MOVEMENT DISORDERS

TSE strain differentiation in mice by immunohistochemical PrPScprofiles and triplex Western blot

(2015) Lucien J. M. van Keulen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders

(2015) Elvira Valera et al.   Neurotherapeutics

Microglia Function in Central Nervous System Development and Plasticity

(2015) Dorothy P. Schafer et al.   Cold Spring Harbor Perspectives in Biology

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

Dysfunction of mitochondrial dynamics in the brains of scrapie-infected mice

(2014) Hong-Seok Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction

(2014) James A. Carroll et al.   JOURNAL OF VIROLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Prions and the Potential Transmissibility of Protein Misfolding Diseases

(2013) Allison Kraus et al.   Annual Review of Microbiology

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

(2013) Dorothy P. Schafer et al.   CURRENT OPINION IN NEUROBIOLOGY

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease

(2013) Kathryn J. Hilton et al.   PLoS One

Elucidating the role of cofactors in mammalian prion propagation

(2013) Surachai Supattapone   Prion

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

(2013) Yihui Fan et al.   Protein & Cell

Prospective Study of Statin Use and Risk of Parkinson Disease

(2012) Xiang Gao   ARCHIVES OF NEUROLOGY

The new role of LOX-1 in hypertension induced neuronal apoptosis

(2012) Yali Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease

(2012) Isaac Crespo et al.   BMC Systems Biology

Presence of an acute phase response in sheep with clinical classical scrapie

(2012) Siv Meling et al.   BMC Veterinary Research

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

(2012) Anil Kumar et al.   BRAIN RESEARCH

Microglia and Inflammation in Alzheimers Disease

(2012) Shweta Mandrekar-Colucci et al.   CNS & Neurological Disorders-Drug Targets

Simvastatin Induces Neuroprotection in 6-OHDA-Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti-Inflammatory Responses

(2012) Yun-Qi Xu et al.   CNS Neuroscience & Therapeutics

Endogenous prion protein conversion is required for prion-induced neuritic alterations and neuronal death

(2012) Sabrina Cronier et al.   FASEB JOURNAL

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

(2012) Norbert Zilka et al.   Journal of Neuroinflammation

Statin use and risk of Parkinson’s disease: a meta-analysis of observational studies

(2012) Krishna Undela et al.   JOURNAL OF NEUROLOGY

Early Cytokine Elevation, PrPres Deposition, and Gliosis in Mouse Scrapie: No Effect on Disease by Deletion of Cytokine Genes IL-12p40 and IL-12p35

(2012) D. Tribouillard-Tanvier et al.   JOURNAL OF VIROLOGY

Prion Propagation and Toxicity Occur In Vitro with Two-Phase Kinetics Specific to Strain and Neuronal Type

(2012) S. Hannaoui et al.   JOURNAL OF VIROLOGY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over (“n-of-1”) exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson's disease patients

(2012) François Tison et al.   PARKINSONISM & RELATED DISORDERS

Disease phenotype in sheep after infection with cloned murine scrapie strains

(2012) Silvia Sisó et al.   Prion

Current and future treatments for Alzheimer’s disease

(2012) Konstantina G. Yiannopoulou et al.   Therapeutic Advances in Neurological Disorders

Effect of Glycans and the Glycophosphatidylinositol Anchor on Strain Dependent Conformations of Scrapie Prion Protein: Improved Purifications and Infrared Spectra

(2011) Gerald S. Baron et al.   BIOCHEMISTRY

Mechanism of PrP-Amyloid Formation in Mice Without Transmissible Spongiform Encephalopathy

(2011) Martin Jeffrey et al.   BRAIN PATHOLOGY

Hepatic acute phase proteins – Regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling

(2011) Johannes G. Bode et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Upregulation Of Interferon-Gamma-Induced Genes During Prion Infection

(2011) Laura R. Moody et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Simvastatin as add-on therapy to interferon beta-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial

(2011) Per Soelberg Sorensen et al.   LANCET NEUROLOGY

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Statins in Neurological Disorders: Mechanisms and Therapeutic Value

(2011) Allison B. Reiss et al.   TheScientificWorldJOURNAL

Morphological and Functional Abnormalities in Mitochondria Associated with Synaptic Degeneration in Prion Disease

(2010) Zuzana Sisková et al.   AMERICAN JOURNAL OF PATHOLOGY

Species-Dependent Differences in Cofactor Utilization for Formation of the Protease-Resistant Prion Protein in Vitro

(2010) Nathan R. Deleault et al.   BIOCHEMISTRY

Identification of USP18 as an Important Regulator of the Susceptibility to IFN-  and Drug-Induced Apoptosis

(2010) H. Potu et al.   CANCER RESEARCH

NF-κB and STAT3 signaling hubs for lung innate immunity

(2010) Lee J. Quinton et al.   CELL AND TISSUE RESEARCH

Statins: Multiple neuroprotective mechanisms in neurodegenerative diseases

(2010) Qing Wang et al.   EXPERIMENTAL NEUROLOGY

Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation

(2010) Martina M. Hughes et al.   GLIA

Oncostatin M synergistically induces CXCL10 and ICAM-1 expression in IL-1β-stimulated-human gingival fibroblasts

(2010) Yoshitaka Hosokawa et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Simvastatin treatment in patients with relapsing-remitting multiple sclerosis receiving interferon beta 1a: a double-blind randomized controlled trial

(2010) Mansoureh Togha et al.   Multiple Sclerosis Journal

Atorvastatin Combined To Interferon to Verify the Efficacy (ACTIVE) in relapsing— remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy

(2010) Roberta Lanzillo et al.   Multiple Sclerosis Journal

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies

(2009) Norbert Zilka et al.   ACTA NEUROPATHOLOGICA

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

Oral pravastatin prolongs survival time of scrapie-infected mice

(2009) V. Vetrugno et al.   JOURNAL OF GENERAL VIROLOGY

Pravastatin and cognitive function in the elderly. Results of the PROSPER study

(2009) Stella Trompet et al.   JOURNAL OF NEUROLOGY

Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

(2009) A. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Analysis of Protein Levels of 24 Cytokines in Scrapie Agent-Infected Brain and Glial Cell Cultures from Mice Differing in Prion Protein Expression Levels

(2009) D. Tribouillard-Tanvier et al.   JOURNAL OF VIROLOGY

A systems approach to prion disease

(2009) Daehee Hwang et al.   Molecular Systems Biology

Induced Neuroprotection Independently From PrPSc Accumulation in a Mouse Model for Prion Disease Treated With Simvastatin

(2008) Yaron Haviv et al.   ARCHIVES OF NEUROLOGY

Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes

(2008) Garrett Sorensen et al.   BMC GENOMICS

Investigation of Mcp1 as a Quantitative Trait Gene for Prion Disease Incubation Time in Mouse

(2008) M. O'Shea et al.   GENETICS

Genes contributing to prion pathogenesis

(2008) G. Tamguney et al.   JOURNAL OF GENERAL VIROLOGY

Evaluation of drugs for treatment of prion infections of the central nervous system

(2008) C. Riemer et al.   JOURNAL OF GENERAL VIROLOGY

Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice

(2008) D. S. Spinner et al.   JOURNAL OF VIROLOGY

Accelerated Prion Replication in, but Prolonged Survival Times of, Prion-Infected CXCR3-/- Mice

(2008) C. Riemer et al.   JOURNAL OF VIROLOGY

Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis

(2008) G. Birnbaum et al.   NEUROLOGY