Article
Cell Biology
Xuan-Cheng He, Jian Wang, Hong-Zhen Du, Chang-Mei Liu, Zhao-Qian Teng
Summary: miRNA let-7i has been proposed as an ideal biomarker for traumatic brain injury (TBI), and its expression is significantly downregulated in the early stages of a hippocampal stab wound injury. The noninvasive intranasal administration of let-7i agomir improves cognitive function, suppresses neuroinflammation, glial scar formation, and neuronal apoptosis in TBI mice. STING is identified as a direct downstream target of let-7i after brain injury. The intranasal delivery of let-7i agomir effectively inhibits STING and benefits inflammation resolution and neuronal survival in a mouse model of pial vessel disruption stroke.
Review
Medicine, General & Internal
Javaid Ahmad Wani, Sabhiya Majid, Andleeb Khan, Azher Arafah, Ajaz Ahmad, Basit Latief Jan, Naveed Nazir Shah, Mohsin Kazi, Muneeb U. Rehman
Summary: miR-146a is a crucial modulator of the innate immune response and has been shown to play a key role in various cancers. It suppresses tumor proliferation and metastasis in lung cancer and has potential as a diagnostic marker for the disease.
Article
Biochemistry & Molecular Biology
Charleine Zussy, Rijo John, Theo Urgin, Lea Otaegui, Claire Vigor, Niyazi Acar, Geoffrey Canet, Mathieu Vitalis, Francoise Morin, Emmanuel Planel, Camille Oger, Thierry Durand, Shinde L. Rajshree, Laurent Givalois, Padma V. Devarajan, Catherine Desrumaux
Summary: Polyunsaturated fatty acids (PUFAs), especially DHA, play a crucial role in brain development and function. Low levels of DHA have been associated with cognitive impairment and AD. The relationship between dietary DHA intake and cognitive decline remains inconclusive. The oxidizability of DHA and its limited accessibility to the brain may contribute to these inconsistencies. New strategies to enhance DHA supply to the brain are needed.
Article
Neurosciences
Donna J. Cross, Bertrand R. Huber, Michael A. Silverman, Marcella M. Cline, Trevor B. Gill, Chloe G. Cross, David G. Cook, Satoshi Minoshima
Summary: Intranasally administered microtubule-stabilizing drugs, specifically paclitaxel, have shown promise in altering the phenotypic progression of Alzheimer's disease in 3xTg-AD mice. These drugs can increase axonal transport rates, reduce phospho-tau containing neurons, improve performance in behavioral tests, and decrease anxiety-related behaviors.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hiroki Toyoda, Ayano Katagiri, Takafumi Kato, Hajime Sato
Summary: Intranasal administration of rotenone impairs conditioned taste aversion memory in mice by decreasing GABAergic synaptic transmission and causing LTD impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ting Pan, Yan Wu, Xu Zhang, Jingfan Wang, Xingxing Wang, Qinyuan Gu, Changlin Xu, Yuanyuan Fan, Xinsheng Li, Ping Xie, Qinghuai Liu, Zizhong Hu
Summary: This study provides the first evidence that exosomes derived from lens epithelial cells can inhibit abnormal ocular neovascularization and attenuate angiogenesis. In vitro experiments demonstrated that these exosomes inhibited the proliferation, migration, and tube formation of endothelial cells under high glucose conditions. Mechanistically, exosomal miR-146a-5p targeted the NRAS coding sequence in endothelial cells, leading to the inactivation of the AKT/ERK signaling pathway.
Article
Geriatrics & Gerontology
Alar Kaskikallio, Mira Karrasch, Juha Koikkalainen, Jyrki Lotjonen, Juha O. Rinne, Terhi Tuokkola, Riitta Parkkola, Petra Gronholm-Nyman
Summary: This study examined the relationship between WMH and verbal fluency in healthy elderly individuals and those with MCI/AD, finding associations between WMH in certain brain areas and impaired semantic fluency, particularly in right-handed participants. Elevated levels of WMH were not found to have cumulative effects on verbal fluency impairment in patients with MCI or AD, suggesting further research is needed in this area.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Cell Biology
Zheng Bao, Li Bao, Na Han, Yueyun Hou, Fumin Feng
Summary: The study demonstrated that repetitive transcranial magnetic stimulation (rTMS) can ameliorate cognitive dysfunction in AD mice by reducing cell apoptosis and activating the cAMP/PKA/CREB signaling pathway.
Article
Pharmacology & Pharmacy
Fanchang Wu, Mingjun Huang, Xue Zuo, Ruiye Xie, Jinman Liu, Junyu Ke, Weirong Li, Qi Wang, Yong Liang
Summary: This study aimed to improve the bioavailability of osthole in the brain by using borneol as a carrier for the treatment of Alzheimer's disease. Results showed that intranasal administration of osthole/borneol significantly increased the concentration of osthole in the cerebrospinal fluid. This enhanced drug delivery system improved cognitive impairment and reduced neuron apoptosis in AD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Haram R. Kim, Lakshmi Rajagopal, Herbert Y. Meltzer, Marco Martina
Summary: This study suggests that altering the polarity of GABA(A) currents in the ILC can improve cognitive performance in a mouse model of schizophrenia, indicating that bumetanide may have the potential to treat or prevent CIAS.
Article
Multidisciplinary Sciences
Jinsu Park, Hee-Jin Ha, Eun Seon Chung, Seung Hyun Baek, Yoonsuk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Jeongmi Lee, Eunae Kim, Junsik Kim, Yong Ryoul Yang, Mikyoung Park, Sung Hyun Kim, Thiruma Arumugam, Hyemin Jang, Sang Won Seo, Pann-Ghill Suh, Dong-Gyu Jo
Summary: O-GlcNAcylation plays a protective role in Alzheimer's disease by inhibiting necroptosis and reducing the AD pathology, including AD burden, neuroinflammation, and damaged mitochondria. This suggests O-GlcNAcylation-based treatments as potential interventions for AD by establishing its influence on AD accumulation and neurodegeneration.
Article
Endocrinology & Metabolism
Min Zeng, Tao-Feng Wei, Cong Chen, Chen Shen, Tong-Yao Gao, Xian Xie, Ming Wu, Yun-Bi Lu, Wei-Ping Zhang
Summary: The study demonstrates that the use of NAMPT inhibitor FK866 can significantly alleviate aging-induced cognitive and locomotor impairments through enhancing autophagy, reducing protein aggregation, and inhibiting neuroinflammation. Although FK866 does not affect the levels of NAD and NMN in the brain, it modulates NAM levels and has no impact on blood glucose, cholesterol, and triglyceride levels.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Samar O. El-Ganainy, Omar A. Soliman, Aya A. Ghazy, Maram Allam, Aya I. Elbahnasi, Amira M. Mansour, Mennatallah A. Gowayed
Summary: Oxytocin has neuroprotective potential in Alzheimer's disease, restoring cognition and suppressing beta-amyloid, Tau accumulation, and neuronal death. Combined treatment with galantamine and oxytocin shows better biochemical and histopathological profiles.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Zsuzsa Lindenmaier, Jacob Ellegood, Monique Stuive, Kaitlyn Easson, Yohan Yee, Darren Fernandes, Jane Foster, Evdokia Anagnostou, Jason P. Lerch
Summary: Although initially promising, oxytocin treatment for the social deficits of autism has encountered obstacles. We conducted a preclinical study on three mouse models and found limited effects of chronic oxytocin treatment, without a clear pattern of treatment response susceptibility.
Article
Medicine, General & Internal
Yoshihisa Fujinami, Shigeaki Inoue, Yuko Ono, Yusuke Miyazaki, Kazumichi Fujioka, Kimihiro Yamashita, Joji Kotani
Summary: Post-intensive care syndrome (PICS) is a physical, cognitive, and mental impairment observed in ICU survivors. By inducing sepsis in mice and using various behavioral tests, researchers have developed a model to study PICS and evaluate the capabilities of surviving mice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Genetics & Heredity
Jia Li, Ding Long, Sisi Wu, Xiaoling Wu, Bohua Wei, Dan Chen, Yiming Shao, Hongliang Wang, Lili Cui, Xiangyan Chen, Li Yu
Article
Cell Biology
Yan Wang, Jing-Qi Yang, Ting-Ting Hong, Yuan-Hong Sun, Hai-Li Huang, Feng Chen, Xiong-Jin Chen, Hui-Yi Chen, Shan-Shan Dong, Li-Li Cui, Tie-Lin Yang
Review
Neurosciences
Weihao Fan, Chunmei Liang, Mingqian Ou, Ting Zou, Furong Sun, Haihong Zhou, Lili Cui
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Review
Clinical Neurology
Ming-Qian Ou, Wei-Hao Fan, Fu-Rong Sun, Wan-Xin Jie, Mei-Jun Lin, Yu-Jie Cai, Shi-Yun Liang, Yang-Sheng Yu, Min-Hua Li, Li-Li Cui, Hai-Hong Zhou
FRONTIERS IN NEUROLOGY
(2020)
Article
Multidisciplinary Sciences
Yiming Shao, Tian Zhao, Wenying Zhang, Junbing He, Furong Lu, Yujie Cai, Zhipeng Lai, Ning Wei, Chunmei Liang, Lizhen Liu, Yuan Hong, Xiaohong Cheng, Jia Li, Pei Tang, Weihao Fan, Mingqian Ou, Jingqi Yang, Yansong Liu, Lili Cui
SCIENTIFIC REPORTS
(2020)
Review
Neurosciences
Xiangming Xu, Lili Cui, Wangtao Zhong, Yujie Cai
Review
Cell Biology
Xu Zhou, Xiongjin Chen, Tingting Hong, Miaoping Zhang, Yujie Cai, Lili Cui
Summary: The TTC3 gene is located within the Down's syndrome critical region, and its overexpression can accelerate cognitive decline, though the specific mechanism is unknown. TTC3 participates in protein quality control through assisting correct protein folding, degradation, and potentially inducing autophagy, making it a potential target in the treatment of DS and AD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Feng Chen, Huiyi Chen, Yanting Chen, Wenyan Wei, Yuanhong Sun, Lu Zhang, Lili Cui, Yan Wang
Summary: Communication between neurons relies on synaptic vesicle exocytosis, a process facilitated by the SNARE complex. Dysfunction of the SNARE complex in synapses may contribute to abnormal neurotransmission and lead to synaptic dysfunction. Research suggests that the SNARE complex could be a significant molecular target in neurological diseases.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cui
Summary: Microglia play a crucial role in the progression of AD, especially in relation to the risk factors of APOE genotype, sex, and aging. The interaction between microglia and these risk factors can exacerbate neurodegeneration and contribute to the risk of AD. Additionally, new microglia replacement after depletion shows promise in AD treatment as a potential strategy.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Haihong Zhou, Furong Sun, Mingqian Ou, Yu Zhang, Meijun Lin, Liqin Song, Yangsheng Yu, Haojie Liao, Weihao Fan, Huaijie Xing, Minhua Li, Kui Zhao, Xiaolian Wu, Yuanhong Sun, Chunmei Liang, Yujie Cai, Lili Cui
Summary: The study revealed that miR-122-5p plays a crucial role in regulating neuroinflammation in radiation-induced brain injury (RBI), suggesting that inhibiting miR-122-5p could alleviate radiation-induced cognitive impairment, neuronal injury, and neuroinflammation. The results also indicated that miR-122-5p inhibition in microglia may reduce proinflammatory cytokine levels and enhance phagocytic function to protect against radiation-induced neuronal injury, with Tensin 1 identified as a potential target of miR-122-5p in RBI. Additional safety assessments, optimization of drug delivery, and clarification of mechanisms are needed for clinical translation.
Review
Neurosciences
Huiyi Chen, Feng Chen, Miaoping Zhang, Yanting Chen, Lili Cui, Chunmei Liang
Summary: This review highlights the potential pathogenic effects of ApoE4 on autophagy and its associations with the biological hallmarks of autophagy and Alzheimer's disease. Different ApoE isoforms modulate autophagy through various signaling pathway markers, suggesting that dysregulation of autophagic flux is a key mechanism for the convergence of multiple pathogenic processes.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weina Zhao, Changhao Yin, Fengbo Yu, Lifei Wan, Siyao Che, Lili Cui
Summary: This study explored the value of brain structure MRI combined with APOE-epsilon 4 genotype in the early diagnosis and disease progression of elderly patients with vascular cognitive impairment no dementia (VCIND). The results showed that years of education, hypertension, high levels of homocysteine, elevated WMV, WMH, LI, Fazekas scores, and carrying the APOE-epsilon 4 gene were risk factors for VCIND in stroke patients.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Biology
Mingqian Ou, Weihao Fan, Furong Sun, Minhua Li, Meijun Lin, Yangsheng Yu, Shiyun Liang, Haojie Liao, Wanxin Jie, Yujie Cai, Feng Chen, Xiongjin Chen, Tian Zhao, Pei Tang, Lili Cui, Haihong Zhou
Summary: The study identified miR-741-3p as a significant player in radiation-induced brain injury, showing that inhibiting miR-741-3p can alleviate cognitive dysfunction and neuronal apoptosis caused by radiation. Downregulation of miR-741-3p also improves microglia status, reduces astrocyte numbers, and suppresses the production of inflammatory cytokines.
RADIATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Chunmei Liang, Ting Zou, Miaoping Zhang, Weihao Fan, Tianzhen Zhang, Yuling Jiang, Yujie Cai, Feng Chen, Xiongjin Chen, Yuanhong Sun, Bin Zhao, Yan Wang, Lili Cui
Summary: Alzheimer's disease has no effective treatment, with research focused on Aβ and Tau. Abnormal microglial polarization is a key feature in the progression of AD, affecting neuroprotective functions. MiR-146a shows promise in opposing AD by switching microglial phenotypes and reducing neuroinflammation.
Article
Clinical Neurology
Xu Zhou, Jun Chen, Hua Tao, Yujie Cai, Lidan Huang, Haihong Zhou, Yanyan Chen, Lili Cui, Wangtao Zhong, Keshen Li
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2020)