dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection

Longitudinal analysis of the 5′UTR, E2-PePHD and NS5A-PKRBD genomic regions of hepatitis C virus genotype 1a in association with the response to peginterferon and ribavirin therapy in HIV-coinfected patients

(2012) Federico Bolcic et al.   ANTIVIRAL RESEARCH

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

(2012) François Mouton-Liger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G1arrest

(2012) Richard Bennett et al.   CELL CYCLE

Dynamic Oscillation of Translation and Stress Granule Formation Mark the Cellular Response to Virus Infection

(2012) Alessia Ruggieri et al.   Cell Host & Microbe

Regulation of Actin Dynamics by Protein Kinase R Control of Gelsolin Enforces Basal Innate Immune Defense

(2012) Aaron T. Irving et al.   IMMUNITY

West Nile Virus Infections Suppress Early Viral RNA Synthesis and Avoid Inducing the Cell Stress Granule Response

(2012) S. C. Courtney et al.   JOURNAL OF VIROLOGY

The Double-Stranded RNA Bluetongue Virus Induces Type I Interferon in Plasmacytoid Dendritic Cells via a MYD88-Dependent TLR7/8-Independent Signaling Pathway

(2012) S. Ruscanu et al.   JOURNAL OF VIROLOGY

Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus

(2012) Z. Li et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus (HCV) Induces Formation of Stress Granules Whose Proteins Regulate HCV RNA Replication and Virus Assembly and Egress

(2012) U. Garaigorta et al.   JOURNAL OF VIROLOGY

The Multiple Functions of TRBP, at the Hub of Cell Responses to Viruses, Stress, and Cancer

(2012) S. M. Daniels et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

(2012) Koji Onomoto et al.   PLoS One

The PKR Activator PACT Is Induced by Aβ: Involvement in Alzheimer's Disease

(2011) Claire Paquet et al.   BRAIN PATHOLOGY

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

PERK and PKR: Old kinases learn new tricks

(2011) Jennifer F. Raven et al.   CELL CYCLE

Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment

(2011) Simon Reiss et al.   Cell Host & Microbe

eIF2A mediates translation of hepatitis C viral mRNA under stress conditions

(2011) Joon Hyun Kim et al.   EMBO JOURNAL

IL28B and interferon-gamma inducible protein 10 for prediction of rapid virologic response and sustained virologic response in HIV-HCV-coinfected patients

(2011) Berit A. Payer et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo

(2011) Zuzanna Makowska et al.   HEPATOLOGY

Autophagosomes and human diseases

(2011) Isabelle Beau et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular Mechanism of Signal Perception and Integration by the Innate Immune Sensor Retinoic Acid-inducible Gene-I (RIG-I)

(2011) Marco Binder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poliovirus Switches to an eIF2-Independent Mode of Translation during Infection

(2011) J. P. White et al.   JOURNAL OF VIROLOGY

Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase

(2011) J.-F. Gelinas et al.   JOURNAL OF VIROLOGY

The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1

(2011) M. Chaumorcel et al.   JOURNAL OF VIROLOGY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Identification of a Functional, CRM-1-Dependent Nuclear Export Signal in Hepatitis C Virus Core Protein

(2011) Andrea Cerutti et al.   PLoS One

Antiviral responses induced by the TLR3 pathway

(2011) Misako Matsumoto et al.   REVIEWS IN MEDICAL VIROLOGY

Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response

(2011) Noëlla Arnaud et al.   PLoS Pathogens

Modulation of Tau Phosphorylation by the Kinase PKR: Implications in Alzheimer's Disease

(2010) Anindita Bose et al.   BRAIN PATHOLOGY

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Regulation of innate immunity through RNA structure and the protein kinase PKR

(2010) Subba Rao Nallagatla et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response

(2010) R. Broering et al.   GUT

Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection

(2010) Andrew J. Muir et al.   HEPATOLOGY

Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV

(2010) Armanda Casrouge et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of PKR by HCV IRES RNA: Importance of Domain II and NS5A

(2010) Rebecca Toroney et al.   JOURNAL OF MOLECULAR BIOLOGY

Polo-Like Kinase 1 Is Involved in Hepatitis C Virus Replication by Hyperphosphorylating NS5A

(2010) Y.-C. Chen et al.   JOURNAL OF VIROLOGY

Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress

(2010) W L Blalock et al.   LEUKEMIA

The Double-stranded RNA–dependent Protein Kinase Differentially Regulates Insulin Receptor Substrates 1 and 2 in HepG2 Cells

(2010) Xuerui Yang et al.   MOLECULAR BIOLOGY OF THE CELL

Contribution of Genome-Wide HCV Genetic Differences to Outcome of Interferon-Based Therapy in Caucasian American and African American Patients

(2010) Maureen J. Donlin et al.   PLoS One

Hepatitis C Virus Controls Interferon Production through PKR Activation

(2010) Noëlla Arnaud et al.   PLoS One

Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple levels of PKR inhibition during HIV-1 replication

(2010) Guerline Clerzius et al.   REVIEWS IN MEDICAL VIROLOGY

Translational insensitivity to potent activation of PKR by HCV IRES RNA

(2009) Takashi Shimoike et al.   ANTIVIRAL RESEARCH

Hepatitis C virus: viral proteins on the move

(2009) John McLauchlan   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural and functional diversity of viral IRESes

(2009) Laurent Balvay et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Hepatitis C Virus Blocks Interferon Effector Function by Inducing Protein Kinase R Phosphorylation

(2009) Urtzi Garaigorta et al.   Cell Host & Microbe

Could PKR inhibition modulate human neurodegeneration?

(2009) Jacques Hugon et al.   Expert Review of Neurotherapeutics

Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system

(2009) Pantxika Bellecave et al.   HEPATOLOGY

RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR

(2009) Ann M. Toth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells

(2009) Susie S. Mikkelsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKR, a cognitive decline biomarker, can regulate translationviatwo consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients

(2009) Milena Damjanac et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment

(2009) L. Chen et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis C virus single-stranded RNA induces innate immunity via Toll-like receptor 7

(2009) Yi-Liang Zhang et al.   JOURNAL OF HEPATOLOGY

Neuronal Phosphorylated RNA-Dependent Protein Kinase in Creutzfeldt-Jakob Disease

(2009) Claire Paquet et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

ADAR1 Interacts with PKR during Human Immunodeficiency Virus Infection of Lymphocytes and Contributes to Viral Replication

(2009) G. Clerzius et al.   JOURNAL OF VIROLOGY

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities

(2009) D. Uzri et al.   JOURNAL OF VIROLOGY

Protein Kinase PKR-Dependent Activation of Mitogen-Activated Protein Kinases Occurs through Mitochondrial Adapter IPS-1 and Is Antagonized by Vaccinia Virus E3L

(2009) P. Zhang et al.   JOURNAL OF VIROLOGY

Vaccinia Virus E3 Suppresses Expression of Diverse Cytokines through Inhibition of the PKR, NF- B, and IRF3 Pathways

(2009) C. Myskiw et al.   JOURNAL OF VIROLOGY

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

(2009) M. Sarasin-Filipowicz et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Liver Cancer-Derived Hepatitis C Virus Core Proteins Shift TGF-Beta Responses from Tumor Suppression to Epithelial-Mesenchymal Transition

(2009) Serena Battaglia et al.   PLoS One

The Evolution of the Major Hepatitis C Genotypes Correlates with Clinical Response to Interferon Therapy

(2009) Phillip S. Pang et al.   PLoS One

RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment

(2009) Zhiqun Li et al.   VIROLOGY

PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control

(2009) Ju-Il Kang et al.   VIRUS RESEARCH

Hepatitis C virus–infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells

(2008) Takashi Ebihara et al.   HEPATOLOGY

TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway

(2008) Ryoko Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells

(2008) J. Chang et al.   JOURNAL OF VIROLOGY

PKR is activated in MDS patients and its subcellular localization depends on disease severity

(2008) M Y Follo et al.   LEUKEMIA

TRBP Control of PACT-Induced Phosphorylation of Protein Kinase R Is Reversed by Stress

(2008) A. Daher et al.   MOLECULAR AND CELLULAR BIOLOGY

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2

(2008) Ilya M Terenin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON

Interferon signaling and treatment outcome in chronic hepatitis C

(2008) M. Sarasin-Filipowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA